LYS9_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYS9_YEAST
• UniProt AC: P38999
• Protein Name: Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]
• Gene Name: LYS9
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 446
• Protein Sequence: MGKNVLLLGSGFVAQPVIDTLAANDDINVTVACRTLANAQALAKPSGSKAISLDVTDDSALDKVLADNDVVISLIPYTFHPNVVKSAIRTKTDVVTSSYISPALRELEPEIVKAGITVMNEIGLDPGIDHLYAVKTIDEVHRAGGKLKSFLSYCGGLPAPEDSDNPLGYKFSWSSRGVLLALRNSAKYWKDGKIETVSSEDLMATAKPYFIYPGYAFVCYPNRDSTLFKDLYHIPEAETVIRGTLRYQGFPEFVKALVDMGMLKDDANEIFSKPIAWNEALKQYLGAKSTSKEDLIASIDSKATWKDDEDRERILSGFAWLGLFSDAKITPRGNALDTLCARLEELMQYEDNERDMVVLQHKFGIEWADGTTETRTSTLVDYGKVGGYSSMAATVGYPVAIATKFVLDGTIKGPGLLAPYSPEINDPIMKELKDKYGIYLKEKTVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	ANAQALAKPSGSKAI HHHHHHHCCCCCCCE	40.33	17644757
49	Ubiquitination	LAKPSGSKAISLDVT HHCCCCCCCEEEECC	53.95	17644757
148	Ubiquitination	HRAGGKLKSFLSYCG HHCCCCHHHHHHHCC	42.52	17644757
170	Ubiquitination	SDNPLGYKFSWSSRG CCCCCCCEEEECHHH	30.99	17644757
187	Acetylation	LALRNSAKYWKDGKI HHHHCCHHHHCCCCE	52.01	25381059
196	Phosphorylation	WKDGKIETVSSEDLM HCCCCEEECCHHHHH	29.21	21126336
199	Phosphorylation	GKIETVSSEDLMATA CCEEECCHHHHHHHC	30.69	27017623
205	Phosphorylation	SSEDLMATAKPYFIY CHHHHHHHCCCEEEE	22.65	27017623
209	Phosphorylation	LMATAKPYFIYPGYA HHHHCCCEEEECCEE	11.25	29650682
229	Acetylation	NRDSTLFKDLYHIPE CCCCCCHHHHCCCCH	50.35	24489116
264	Acetylation	LVDMGMLKDDANEIF HHHCCCCCCCHHHHH	44.67	25381059
273	Acetylation	DANEIFSKPIAWNEA CHHHHHCCCCHHHHH	29.69	25381059
292	Acetylation	LGAKSTSKEDLIASI HCCCCCCHHHHHHHC	56.17	24489116
403	Phosphorylation	GYPVAIATKFVLDGT CCCCEEEEEEEECCC	20.92	27017623
412	Ubiquitination	FVLDGTIKGPGLLAP EEECCCCCCCCCCCC	59.91	17644757
420	Phosphorylation	GPGLLAPYSPEINDP CCCCCCCCCCCCCCH	31.11	26447709
421	Phosphorylation	PGLLAPYSPEINDPI CCCCCCCCCCCCCHH	18.26	26447709
430	Ubiquitination	EINDPIMKELKDKYG CCCCHHHHHHHHHHC	61.69	17644757

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYS9_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYS9_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYS9_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HSP71_YEAST	SSA1	physical	16429126
GRP78_YEAST	KAR2	physical	16429126
LYS9_YEAST	LYS9	physical	16943620

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.