dbPTM

GIS3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GIS3_YEAST
UniProt AC	Q12418
Protein Name	Protein GIS3
Gene Name	GIS3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	502
Subcellular Localization	Cytoplasm . Nucleus .
Protein Description
Protein Sequence	MLLDVNTNHTLMHDAHVHEHCLIKSIRDDGALHSWSDSSKVFYPKSFYATATNKKNNKLASASMNKTATSNRTVSDEIYFHSTKPQFDGQGSAERTRTLTKRNSFKRTRILKARDDSELLNENRSSLMTPSLSSVMSQVRKTNSAKTLSGECPIHEGHLTQSIKRKFSEEAQSDCSSLSSSKLHPLTDDIADAVDLQTPAIGDEVLAEPVVPKMKIININDLDLFDDWEVKDLVDIFPPVYERRPRSSSALSLVSASSDAKLRPTSVDFQIIDKKGGKTSRRKSRSKSTTENMIYENDLVELEQWPSASPSPETDGSIASSELLPNKRIRQKSLNTNFLKLYSIETSCKRKSILPEVEVDDHLLKQLTYSEIRSLEIKKEPNVSTNDIKLALITRKKLWSDMVHETRNDLFGDSTPWNLHFVATTSNTEPSQGRESASEHATADLKSSLVRVHSDVKPWFNNGGTMLKPCGKLNLGKVTNKTSAPTREIQYVVKGWCDSRFL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	ENRSSLMTPSLSSVM CCHHHCCCCCHHHHH	18.28	27017623
131	Phosphorylation	RSSLMTPSLSSVMSQ HHHCCCCCHHHHHHH	31.55	27017623
137	Phosphorylation	PSLSSVMSQVRKTNS CCHHHHHHHHHHCCC	24.30	27017623
162	Phosphorylation	HEGHLTQSIKRKFSE CCCCHHHHHHHHCCH	25.49	21440633
168	Phosphorylation	QSIKRKFSEEAQSDC HHHHHHCCHHHHHHH	37.25	23749301
176	Phosphorylation	EEAQSDCSSLSSSKL HHHHHHHHHCCCCCC	39.03	21440633
241	Phosphorylation	VDIFPPVYERRPRSS HHCCCCHHCCCCCCC	14.97	21440633
252	Phosphorylation	PRSSSALSLVSASSD CCCCCCHHHHHCCCC	26.83	27017623
257	Phosphorylation	ALSLVSASSDAKLRP CHHHHHCCCCCCCCC	22.65	21440633
265	Phosphorylation	SDAKLRPTSVDFQII CCCCCCCCEECEEEE	34.64	29688323
266	Phosphorylation	DAKLRPTSVDFQIID CCCCCCCEECEEEEC	23.52	29688323
333	Phosphorylation	NKRIRQKSLNTNFLK CHHHHCCCCCCCHHH	20.65	21440633
454	Phosphorylation	SSLVRVHSDVKPWFN HHHEEECCCCCCCCC	41.04	23749301
465	Phosphorylation	PWFNNGGTMLKPCGK CCCCCCCCEEEECCC	22.26	23749301
468	Ubiquitination	NNGGTMLKPCGKLNL CCCCCEEEECCCCCC	27.69	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GIS3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GIS3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GIS3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPR1_YEAST	GPR1	genetic	27708008
IES1_YEAST	IES1	genetic	27708008
CHS7_YEAST	CHS7	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
RS29B_YEAST	RPS29B	genetic	27708008
MSRA_YEAST	MXR1	genetic	27708008
UBP6_YEAST	UBP6	genetic	27708008
FAB1_YEAST	FAB1	genetic	27708008
YG036_YEAST	YGL036W	genetic	27708008
ARI1_YEAST	ARI1	genetic	27708008
HUR1_YEAST	HUR1	genetic	27708008
RTG2_YEAST	RTG2	genetic	27708008
ADH4_YEAST	ADH4	genetic	27708008
YG2G_YEAST	YGR079W	genetic	27708008
RS23A_YEAST	RPS23A	genetic	27708008
RS23B_YEAST	RPS23A	genetic	27708008
YG5B_YEAST	YGR250C	genetic	27708008
RT102_YEAST	RTT102	genetic	27708008
ECM12_YEAST	ECM12	genetic	27708008
COX23_YEAST	COX23	genetic	27708008
FLX1_YEAST	FLX1	genetic	27708008
SDHX_YEAST	YJL045W	genetic	27708008
AIM24_YEAST	AIM24	genetic	27708008
MSN4_YEAST	MSN4	genetic	27708008
KDX1_YEAST	KDX1	genetic	27708008
OPLA_YEAST	OXP1	genetic	27708008
BAS1_YEAST	BAS1	genetic	27708008
VAC14_YEAST	VAC14	genetic	27708008
ATP10_YEAST	ATP10	genetic	27708008
YL407_YEAST	YLR407W	genetic	27708008
RIM11_YEAST	RIM11	genetic	27708008
ERG2_YEAST	ERG2	genetic	27708008
PHO91_YEAST	PHO91	genetic	27708008
RTG1_YEAST	RTG1	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GIS3_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168, AND MASSSPECTROMETRY.	18407956 [Abstract]