OPLA_YEAST - dbPTM
OPLA_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID OPLA_YEAST
UniProt AC P28273
Protein Name 5-oxoprolinase
Gene Name OXP1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1286
Subcellular Localization Cytoplasm .
Protein Description Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate..
Protein Sequence MQKGNIRIAIDKGGTFTDCVGNIGTGKQEHDTVIKLLSVDPKNYPDAPLEGIRRLLEVLEHKTIPRGIPLDISNVRSLRMGTTLATNCALERNGERCAFITTKGFKDSLLIGDQTRPDIFNLNIKKVVPLYDTVVEIDERVTLEDFSEDPYFTKSSPNEQEGILEGNSGEMVRVIKKPDESSVRSILKVLYASGIKSIAIAFLHSYTFPDHERIVGNIAREIGFSHVSLSSEVSPMIKFLPRAHSSVADAYLTPVIKKYLNSISAGLSHAEDTHIQFMQSDGGLVDGGKFSGLKSILSGPAGGVIGYSSTCYDKNNNIPLIGFDMGGTSTDVSRYGDGRLEHVFETVTAGIIIQSPQLDIHTVAAGGSSILSWKNGLFRVGPDSAAADPGPAAYRKGGPLTITDANLFLGRLVPEFFPKIFGPNEDESLDLETTTLKFRELTDVINKDLNSNLTMEEVAYGFIKVANECMARPVRAITEAKGHVVSQHRLVSFGGAGGQHAIAVADSLGIDTVLIHRYSSILSAYGIFLADVIEENQEPCSFILGEPETILKVKKRFLELSKNSIKNLLSQSFSREDIVLERYLNLRYEGTETSLMILQKYDDQWNFREWFSEAHKKEFGFSFDDKRIIIDDIRIRAIGKSGVRKEKTVDEQLIEISHFKKADVSKDASFTQKAYFDNKWVDTAVFKIDDLPAGTIIEGPAILADGTQTNIILPNSQATILNSHIFIKINQKAAKTLSKSGYELDIDPILLSIFSHRFMDIALQMGTQLRKTSVSTNVKERLDFSCALFDSKGNLVANAPHVPVHLGSMSTCISAQAKLWEGKLKPGDVLITNHPDIGGTHLPDITVITPSFSSTGELIFYVASRAHHADIGGILPGSVPPNSKELYEEGTAIYSELVVKEGIFQEELIYKLFVEDPGKYPGCSGSRRFSDNISDLKAQVAANTKGIQLIGSLTKEYDLATILKYMAAIQTNASESIKKMLAKMVEHFGTTKFSGEDRLDDGSLIKLQVIIRPEKEEYIFNFDGTSPQVYGNLNAPEAITNSAILYCLRCLVGEDIPLNQGCLKPLTIKIPAGSLLSPRSGAAVVGGNVLTSQRVTDVILKTFNVMADSQGDCNNFTFGTGGNSGNKTDKQIKGFGYYETICGGSGAGADSWRGSGWNGSDAVHTNMTNTRMTDTEVFERRYPVLLKEFSIRRGSGGKGKYTGGNGVVRDVQFRKAVTASILSERRVIGPHGIKGGQDGSRGENLWVRHSTGALINVGGKNTIYAQPGDRFIIKTPGGGGFGQYKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
12UbiquitinationNIRIAIDKGGTFTDC
CEEEEECCCCCEECC		53.8023749301
38PhosphorylationDTVIKLLSVDPKNYP
CCEEEEEECCCCCCC		34.6029734811
42AcetylationKLLSVDPKNYPDAPL
EEEECCCCCCCCCCH		65.7324489116
155PhosphorylationEDPYFTKSSPNEQEG
CCCCCCCCCCCCCCC		48.2322369663
156PhosphorylationDPYFTKSSPNEQEGI
CCCCCCCCCCCCCCE		33.0422369663
188AcetylationSSVRSILKVLYASGI
HHHHHHHHHHHHCCC		28.6424489116
245PhosphorylationKFLPRAHSSVADAYL
HHHCCCCHHHHHHHH		26.0630377154
246PhosphorylationFLPRAHSSVADAYLT
HHCCCCHHHHHHHHH		16.0930377154
562UbiquitinationKRFLELSKNSIKNLL
HHHHHHCHHHHHHHH		68.3023749301
562AcetylationKRFLELSKNSIKNLL
HHHHHHCHHHHHHHH		68.3024489116
588PhosphorylationERYLNLRYEGTETSL
HHHHCCEECCCCEEE		23.1322890988
591PhosphorylationLNLRYEGTETSLMIL
HCCEECCCCEEEEEE		24.9322890988
593PhosphorylationLRYEGTETSLMILQK
CEECCCCEEEEEEHH		27.3122890988
594PhosphorylationRYEGTETSLMILQKY
EECCCCEEEEEEHHC		15.0922890988
660AcetylationLIEISHFKKADVSKD
HHHHHHCCCCCCCCC		41.4424489116
671PhosphorylationVSKDASFTQKAYFDN
CCCCCCCCCCEECCC		27.0228889911
740PhosphorylationAAKTLSKSGYELDID
HHHHHHHCCCCCCCC		43.1425005228
742PhosphorylationKTLSKSGYELDIDPI
HHHHHCCCCCCCCHH		22.0225005228
755PhosphorylationPILLSIFSHRFMDIA
HHHHHHHHHHHHHHH		16.4525005228
773PhosphorylationGTQLRKTSVSTNVKE
CCCCCCCCCCCCHHH		19.6728889911
930PhosphorylationCSGSRRFSDNISDLK
CCCCCCCCCCHHHHH		28.1222369663
952PhosphorylationKGIQLIGSLTKEYDL
CCCHHHCHHCCCCCH		26.3522369663
954PhosphorylationIQLIGSLTKEYDLAT
CHHHCHHCCCCCHHH		24.4322369663
965PhosphorylationDLATILKYMAAIQTN
CHHHHHHHHHHHHCC		6.6419823750
971PhosphorylationKYMAAIQTNASESIK
HHHHHHHCCCCHHHH		27.0019823750
974PhosphorylationAAIQTNASESIKKML
HHHHCCCCHHHHHHH		33.6719823750
976PhosphorylationIQTNASESIKKMLAK
HHCCCCHHHHHHHHH		36.8919823750
1074PhosphorylationTIKIPAGSLLSPRSG
EEEECCCCCCCCCCC		28.3929136822
1077PhosphorylationIPAGSLLSPRSGAAV
ECCCCCCCCCCCCEE		24.4622369663
1200AcetylationRGSGGKGKYTGGNGV
CCCCCCCCCCCCCCE		43.0325381059
1220PhosphorylationFRKAVTASILSERRV
HHHHHHHHHHHCCCE		18.0727017623
1250PhosphorylationENLWVRHSTGALINV
CCEEEEECCCCEEEE		20.2630377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of OPLA_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of OPLA_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of OPLA_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HS104_YEASTHSP104physical
11805837
PFD1_YEASTPFD1physical
19536198
SSB1_YEASTSSB1physical
19536198
CHK1_YEASTCHK1genetic
27708008
ATC3_YEASTDRS2genetic
27708008
YAJ9_YEASTYAR029Wgenetic
27708008
MTU1_YEASTSLM3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
AROF_YEASTARO3genetic
27708008
SPO74_YEASTSPO74genetic
27708008
ASK10_YEASTASK10genetic
27708008
MPM1_YEASTMPM1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
MRT4_YEASTMRT4genetic
27708008
ELM1_YEASTELM1genetic
27708008
MDM35_YEASTMDM35genetic
27708008
COQ11_YEASTYLR290Cgenetic
27708008
PRM6_YEASTPRM6genetic
27708008
SKY1_YEASTSKY1genetic
27708008
TMA23_YEASTTMA23genetic
27708008
SCS7_YEASTSCS7genetic
27708008
ATG3_YEASTATG3genetic
27708008
PHO80_YEASTPHO80genetic
27708008
MET22_YEASTMET22genetic
27708008
RS28A_YEASTRPS28Agenetic
27708008
GSP2_YEASTGSP2genetic
27708008
LIPA_YEASTLIP5genetic
27708008
AIM41_YEASTAIM41genetic
27708008
RAX1_YEASTRAX1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
TGS1_YEASTTGS1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
CTF4_YEASTCTF4genetic
27708008
PMP1_YEASTPMP1physical
26404137
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of OPLA_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-773; SER-930 ANDSER-1077, AND MASS SPECTROMETRY.

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