EFM1_YEAST - dbPTM
EFM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EFM1_YEAST
UniProt AC P38732
Protein Name Protein-lysine N-methyltransferase EFM1 {ECO:0000305|PubMed:20510667}
Gene Name EFM1 {ECO:0000303|PubMed:20510667}
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 585
Subcellular Localization Cytoplasm .
Protein Description S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates elongation factor 1-alpha (TEF1/TEF2) at 'Lys-30'..
Protein Sequence MITQTELDNCLQWAQNNGAFIDPKISFRITEDAGVSAFVNEKFSPKPDQALIRVPETLLITSQQALSEFSQAANERSLLNSVTQLYLSKLKFGTDAVHLKSFYKPYLDVLPLHLPQPYFWSTDEVMNLHGTDVYLTMRDTLNKLVKEWRMLFQALSIEHSSQDKQFLSLFQENKDSAVVPLEQFCAHINGCKLEDSEWNSFVAYLWSYCIFNSRAFPRVILGRAGTDRTNLNEGFLYPIVDLLNHKNDVPVRWEMNEQNELCFMSQTTTFSAQDELFNNYGNISNEKCLLNYGFWDSSNKFDFSRLTLKLPSTLVSGLPVDFNKSGNFVTDDGETTILQFSLKISEPLPPVLLALFAYLSKLKSEETPTVRSVLEGIDQLTSVVSQRLLFYKNFKIKTSSTQKLRPHVIKLIKLYYQDNKKILNATTEKLSVLQKKIYSNNKEFSLSFKTIFKNDKIFANSLLLVFGAINYEDLITKDCLNDALLLWIVKLINDKSNNQGGFIKQTFKEVSDSIVIEKEDVMEFLPFYKKYFPNLSERIPEIYSVGDWGIRQFIVADTAIDRLVWIRKSNKEPIFLMKKAYDLQI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
77PhosphorylationSQAANERSLLNSVTQ
HHHHHHHHHHHHHHH		30.9119684113
81PhosphorylationNERSLLNSVTQLYLS
HHHHHHHHHHHHHHH		26.8919684113
392AcetylationSQRLLFYKNFKIKTS
HHHHHHEECCEECCC		48.8824489116
413AcetylationPHVIKLIKLYYQDNK
HHHHHHHHHHHHCCH		40.6524489116
415PhosphorylationVIKLIKLYYQDNKKI
HHHHHHHHHHCCHHH		8.2828889911
416PhosphorylationIKLIKLYYQDNKKIL
HHHHHHHHHCCHHHH		21.5928889911
531PhosphorylationFLPFYKKYFPNLSER
HHHHHHHHCCCHHHH		21.8127017623
544PhosphorylationERIPEIYSVGDWGIR
HHCCCEEEECCCHHH		25.8627017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EFM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EFM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EFM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARO1_YEASTARO1genetic
17314980
MED8_YEASTMED8genetic
17314980
CKS1_YEASTCKS1genetic
17314980
RTG3_YEASTRTG3genetic
17314980
YM01_YEASTYMR111Cphysical
18719252
SSB1_YEASTSSB1physical
19536198
MOB2_YEASTMOB2genetic
27708008
DED1_YEASTDED1genetic
27708008
NU145_YEASTNUP145genetic
27708008
COG2_YEASTCOG2genetic
27708008
ORC6_YEASTORC6genetic
27708008
TIM16_YEASTPAM16genetic
27708008
HSP77_YEASTSSC1genetic
27708008
CDC11_YEASTCDC11genetic
27708008
TIM14_YEASTPAM18genetic
27708008
ERB1_YEASTERB1genetic
27708008
LIP1_YEASTLIP1genetic
27708008
TIM23_YEASTTIM23genetic
27708008
GRPE_YEASTMGE1genetic
27708008
MED10_YEASTNUT2genetic
27708008
PRKRA_HUMANPRKRAphysical
27107014
COIL_HUMANCOILphysical
27107014
ZMAT4_HUMANZMAT4physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EFM1_YEAST

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Related Literatures of Post-Translational Modification

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