P5CR_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P5CR_YEAST
• UniProt AC: P32263
• Protein Name: Pyrroline-5-carboxylate reductase
• Gene Name: PRO3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 286
• Protein Sequence: MTYTLAILGCGVMGQALLSAIYNAPKAADETAAAFYPSKIITCNHDEPSAQQVTDLVETFDESPNGIKVESTYGHNVSAVEEASVVLLGTKPFLAEEVLNGVKSVIGGKLLISLAAGWTIDQLSQYTSTVCRVMTNTPAKYGYGCAVVSYSADVSKEQKPLVNELISQVGKYVELPEKNMDAATALVGSGPAFVLLMLESLMESGLKLGIPLQESKECAMKVLEGTVKMVEKSGAHPSVLKHQVCTPGGTTIAGLCVMEEKGVKSGIINGVEEAARVASQLGQKKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTYTLAILG ------CCEEEEHHC	25.80	30377154
3	Phosphorylation	-----MTYTLAILGC -----CCEEEEHHCC	9.84	30377154
22	Phosphorylation	QALLSAIYNAPKAAD HHHHHHHHCCCHHCC	12.65	28132839
140	Ubiquitination	VMTNTPAKYGYGCAV HHCCCCCCCCCCEEE	40.17	23749301
151	Phosphorylation	GCAVVSYSADVSKEQ CEEEEEEECCCCHHH	15.53	27017623
159	Acetylation	ADVSKEQKPLVNELI CCCCHHHHHHHHHHH	41.22	24489116
171	Acetylation	ELISQVGKYVELPEK HHHHHHHHHCCCCCC	47.46	24489116
171	Ubiquitination	ELISQVGKYVELPEK HHHHHHHHHCCCCCC	47.46	23749301
216	Ubiquitination	GIPLQESKECAMKVL CCCHHHCHHHHHHHH	56.94	23749301
216	Succinylation	GIPLQESKECAMKVL CCCHHHCHHHHHHHH	56.94	23954790
216	Acetylation	GIPLQESKECAMKVL CCCHHHCHHHHHHHH	56.94	24489116
221	Ubiquitination	ESKECAMKVLEGTVK HCHHHHHHHHHHHHH	25.74	23749301
228	Ubiquitination	KVLEGTVKMVEKSGA HHHHHHHHHHHHCCC	36.75	23749301
228	Acetylation	KVLEGTVKMVEKSGA HHHHHHHHHHHHCCC	36.75	24489116
232	Acetylation	GTVKMVEKSGAHPSV HHHHHHHHCCCCHHH	42.66	22865919
232	Ubiquitination	GTVKMVEKSGAHPSV HHHHHHHHCCCCHHH	42.66	23749301
233	Phosphorylation	TVKMVEKSGAHPSVL HHHHHHHCCCCHHHH	27.92	28889911
246	Phosphorylation	VLKHQVCTPGGTTIA HHCEEEECCCCCEEE	26.55	21440633
250	Phosphorylation	QVCTPGGTTIAGLCV EEECCCCCEEEEEEE	22.42	28889911
251	Phosphorylation	VCTPGGTTIAGLCVM EECCCCCEEEEEEEE	16.47	29734811
261	Ubiquitination	GLCVMEEKGVKSGII EEEEECCCCCCCCCC	56.55	22817900
264	Ubiquitination	VMEEKGVKSGIINGV EECCCCCCCCCCCHH	52.19	23749301
265	Phosphorylation	MEEKGVKSGIINGVE ECCCCCCCCCCCHHH	32.58	21440633
279	Phosphorylation	EEAARVASQLGQKKK HHHHHHHHHHCCCCC	24.07	22369663
284	Succinylation	VASQLGQKKK----- HHHHHCCCCC-----	61.81	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P5CR_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P5CR_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P5CR_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
P5CR_YEAST	PRO3	physical	10688190
URE2_YEAST	URE2	genetic	12620851
MAM33_YEAST	MAM33	physical	16554755
NAP1_YEAST	NAP1	physical	16554755
COPB2_YEAST	SEC27	physical	18467557
P5CR_YEAST	PRO3	physical	18467557
ATX1_YEAST	ATX1	physical	18467557
P5CR_YEAST	PRO3	physical	18719252
PUT4_YEAST	PUT4	genetic	16941010
UBR1_YEAST	UBR1	genetic	22670231
SAN1_YEAST	SAN1	genetic	22670231
COPB2_YEAST	SEC27	physical	22615397
PUT1_YEAST	PUT1	genetic	25112878

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-246 AND SER-279, ANDMASS SPECTROMETRY.
PubMed: 18407956