| UniProt ID | HEM1_YEAST | |
|---|---|---|
| UniProt AC | P09950 | |
| Protein Name | 5-aminolevulinate synthase, mitochondrial {ECO:0000303|PubMed:6381051} | |
| Gene Name | HEM1 {ECO:0000303|PubMed:3516694} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 548 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.. | |
| Protein Sequence | MQRSIFARFGNSSAAVSTLNRLSTTAAPHAKNGYATATGAGAAAATATASSTHAAAAAAAAANHSTQESGFDYEGLIDSELQKKRLDKSYRYFNNINRLAKEFPLAHRQREADKVTVWCSNDYLALSKHPEVLDAMHKTIDKYGCGAGGTRNIAGHNIPTLNLEAELATLHKKEGALVFSSCYVANDAVLSLLGQKMKDLVIFSDELNHASMIVGIKHANVKKHIFKHNDLNELEQLLQSYPKSVPKLIAFESVYSMAGSVADIEKICDLADKYGALTFLDEVHAVGLYGPHGAGVAEHCDFESHRASGIATPKTNDKGGAKTVMDRVDMITGTLGKSFGSVGGYVAASRKLIDWFRSFAPGFIFTTTLPPSVMAGATAAIRYQRCHIDLRTSQQKHTMYVKKAFHELGIPVIPNPSHIVPVLIGNADLAKQASDILINKHQIYVQAINFPTVARGTERLRITPTPGHTNDLSDILINAVDDVFNELQLPRVRDWESQGGLLGVGESGFVEESNLWTSSQLSLTNDDLNPNVRDPIVKQLEVSSGIKQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 23 | Phosphorylation | VSTLNRLSTTAAPHA HHHHHHHHCCCCCCC | 22.07 | 19779198 | |
| 24 | Phosphorylation | STLNRLSTTAAPHAK HHHHHHHCCCCCCCC | 25.66 | 19779198 | |
| 25 | Phosphorylation | TLNRLSTTAAPHAKN HHHHHHCCCCCCCCC | 19.90 | 19779198 | |
| 101 | Acetylation | NNINRLAKEFPLAHR HHHHHHHHHCCCHHH | 65.56 | 24489116 | |
| 120 | Phosphorylation | DKVTVWCSNDYLALS CEEEEEECCCHHHHH | 19.61 | 19779198 | |
| 139 | Phosphorylation | VLDAMHKTIDKYGCG HHHHHHHHHHHCCCC | 21.52 | 19779198 | |
| 142 | Acetylation | AMHKTIDKYGCGAGG HHHHHHHHCCCCCCC | 39.43 | 22865919 | |
| 196 | Acetylation | VLSLLGQKMKDLVIF HHHHHCHHHHHEEEE | 46.23 | 25381059 | |
| 227 | Acetylation | NVKKHIFKHNDLNEL HHHHHHHCCCCHHHH | 40.68 | 24489116 | |
| 337 | N6-(pyridoxal phosphate)lysine | MITGTLGKSFGSVGG HHHCCCCCCCCHHHH | 45.80 | - | |
| 337 | Acetylation | MITGTLGKSFGSVGG HHHCCCCCCCCHHHH | 45.80 | 24489116 | |
| 337 | Other | MITGTLGKSFGSVGG HHHCCCCCCCCHHHH | 45.80 | - | |
| 351 | Acetylation | GYVAASRKLIDWFRS HHHHHHHHHHHHHHH | 47.50 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HEM1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HEM1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HEM1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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