KPR3_YEAST - dbPTM
KPR3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KPR3_YEAST
UniProt AC P38689
Protein Name Ribose-phosphate pyrophosphokinase 3
Gene Name PRS3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 320
Subcellular Localization Cytoplasm .
Protein Description 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5)..
Protein Sequence MPTNSIKLLAPDVHRGLAELVAKRLGLQLTSSKLKRDPTGEVSFSIGESVRDQDIFIITQIGSGVVNDRVLELLIMINASKTASARRITAIIPNFPYARQDRKDKSRAPITAKLMADMLTTAGCDHVITMDLHASQIQGFFDVPVDNLYAEPSVVRYIKENVNYMDSIIISPDAGGAKRAATLADRLDLNFALIHKERARANEVSRMVLVGDVTDKICIIVDDMADTCGTLAKAAEILLENRAKSVIAIVTHGVLSGRAIENINNSKLDRVVCTNTVPFEEKIKKCPKLAVIDISSVLAESIRRLHNGESISYLFKNYPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23UbiquitinationGLAELVAKRLGLQLT
HHHHHHHHHHCCCCC		40.4523749301
167PhosphorylationENVNYMDSIIISPDA
HHCCCCCEEEECCCC		10.1228889911
171PhosphorylationYMDSIIISPDAGGAK
CCCEEEECCCCCCHH		13.3028889911
244UbiquitinationILLENRAKSVIAIVT
HHHHCCCCEEEEEEE		41.8617644757
267UbiquitinationIENINNSKLDRVVCT
HHHCCCCCCCEEEEC		57.4323749301
267AcetylationIENINNSKLDRVVCT
HHHCCCCCCCEEEEC		57.4324489116
282AcetylationNTVPFEEKIKKCPKL
CCCCHHHHHHCCCCE		53.2624489116
288UbiquitinationEKIKKCPKLAVIDIS
HHHHCCCCEEEEEHH		59.5617644757
316UbiquitinationESISYLFKNYPL---
CCCHHHCCCCCC---		53.6423749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KPR3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KPR3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KPR3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
WHI2_YEASTWHI2genetic
10514564
KPR5_YEASTPRS5genetic
9829955
HSP60_YEASTHSP60physical
16429126
RL30_YEASTRPL30physical
16429126
RSSA1_YEASTRPS0Aphysical
16429126
GFA1_YEASTGFA1physical
16429126
HSC82_YEASTHSC82physical
16429126
MPG1_YEASTPSA1physical
16429126
TBA1_YEASTTUB1physical
16429126
KPR1_YEASTPRS1physical
16429126
KPR5_YEASTPRS5physical
18467557
KPR3_YEASTPRS3physical
18467557
HDA1_YEASTHDA1genetic
21288874
HDA2_YEASTHDA2genetic
21288874
PSA3_YEASTPRE9genetic
21288874
RPN10_YEASTRPN10genetic
21288874
COG4_YEASTCOG4genetic
21288874
UBP8_YEASTUBP8genetic
21288874
SWR1_YEASTSWR1genetic
21288874
VPS72_YEASTVPS72genetic
21288874
SRS2_YEASTSRS2genetic
21459050
TREA_YEASTNTH1genetic
21623372
EFM7_YEASTNNT1genetic
21623372
FOLE_YEASTMET7genetic
21623372
ADH3_YEASTADH3genetic
21623372
ACON_YEASTACO1genetic
21623372
KAD2_YEASTADK1genetic
21623372
RLM1_YEASTRLM1physical
27744273
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KPR3_YEAST

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Related Literatures of Post-Translational Modification

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