DBP8_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DBP8_YEAST
• UniProt AC: P38719
• Protein Name: ATP-dependent RNA helicase DBP8
• Gene Name: DBP8
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 431
• Subcellular Localization: Nucleus, nucleolus .
• Protein Description: ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth..
• Protein Sequence: MADFKSLGLSKWLTESLRAMKITQPTAIQKACIPKILEGRDCIGGAKTGSGKTIAFAGPMLTKWSEDPSGMFGVVLTPTRELAMQIAEQFTALGSSMNIRVSVIVGGESIVQQALDLQRKPHFIIATPGRLAHHIMSSGDDTVGGLMRAKYLVLDEADILLTSTFADHLATCISALPPKDKRQTLLFTATITDQVKSLQNAPVQKGKPPLFAYQVESVDNVAIPSTLKIEYILVPEHVKEAYLYQLLTCEEYENKTAIIFVNRTMTAEILRRTLKQLEVRVASLHSQMPQQERTNSLHRFRANAARILIATDVASRGLDIPTVELVVNYDIPSDPDVFIHRSGRTARAGRIGDAISFVTQRDVSRIQAIEDRINKKMTETNKVHDTAVIRKALTKVTKAKRESLMAMQKENFGERKRQQKKKQNDGKSLRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	LGLSKWLTESLRAMK HCHHHHHHHHHHHCC	23.55	26447709
16	Phosphorylation	LSKWLTESLRAMKIT HHHHHHHHHHHCCCC	20.23	26447709
378	Phosphorylation	DRINKKMTETNKVHD HHHHHHHCCCCCCCC	48.84	28889911
427	Acetylation	KKKQNDGKSLRS--- HHHHCCCCCCCC---	49.53	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DBP8_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DBP8_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DBP8_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
COPB_YEAST	SEC26	physical	11805837
OAT_YEAST	CAR2	physical	11805837
DLHH_YEAST	YDL086W	physical	11805837
OYE2_YEAST	OYE2	physical	11805837
RIR1_YEAST	RNR1	physical	11805837
IF4A_YEAST	TIF2	physical	11805837
THI22_YEAST	THI22	physical	11805837
PGM2_YEAST	PGM2	physical	11805837
PFKA1_YEAST	PFK1	physical	11805837
RPN1_YEAST	RPN1	physical	11805837
CDC15_YEAST	CDC15	physical	11805837
ODO1_YEAST	KGD1	physical	11805837
RIR2_YEAST	RNR2	physical	11805837
CARB_YEAST	CPA2	physical	11805837
EF3B_YEAST	HEF3	physical	11805837
IMH1_YEAST	IMH1	physical	16554755
RL15A_YEAST	RPL15A	physical	16429126
RL3_YEAST	RPL3	physical	16429126
RL6A_YEAST	RPL6A	physical	16429126
RL8A_YEAST	RPL8A	physical	16429126
RS11A_YEAST	RPS11A	physical	16429126
RS11B_YEAST	RPS11A	physical	16429126
ARB1_YEAST	ARB1	physical	16429126
RS22A_YEAST	RPS22A	physical	16429126
RS8A_YEAST	RPS8A	physical	16429126
RS8B_YEAST	RPS8A	physical	16429126
RS24A_YEAST	RPS24B	physical	16429126
RS24B_YEAST	RPS24B	physical	16429126
RS17A_YEAST	RPS17A	physical	16429126
RS3_YEAST	RPS3	physical	16429126
RL4A_YEAST	RPL4A	physical	16429126
RLA0_YEAST	RPP0	physical	16429126
KPYK1_YEAST	CDC19	physical	16429126
RIR1_YEAST	RNR1	physical	16429126
METK1_YEAST	SAM1	physical	16429126
ACS2_YEAST	ACS2	physical	16429126
TCPD_YEAST	CCT4	physical	16429126
TCPZ_YEAST	CCT6	physical	16429126
IDH2_YEAST	IDH2	physical	16429126
THDH_YEAST	ILV1	physical	16429126
MAOM_YEAST	MAE1	physical	16429126
NEW1_YEAST	NEW1	physical	16429126
RPN1_YEAST	RPN1	physical	16429126
METK2_YEAST	SAM2	physical	16429126
OLA1_YEAST	OLA1	physical	16429126
EF3A_YEAST	YEF3	physical	16429126
ESF2_YEAST	ESF2	physical	16772403
YKH5_YEAST	YKL075C	physical	11283351
MPP10_YEAST	MPP10	physical	16449634

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.