dbPTM

SYPM_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYPM_YEAST
UniProt AC	P39965
Protein Name	Probable proline--tRNA ligase, mitochondrial
Gene Name	AIM10
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	576
Subcellular Localization	Mitochondrion .
Protein Description
Protein Sequence	MLKYRTLSRSCHIFHPKSLSNNTLKSETTQELLQTVGFVRRSQVGLFQWLPLGLRSLNKVSNAIRNRMDSDGGAIEVSLSAISSKALWQATDRWNNSELFKLKDSKGKQYCLTATCEEDITDLMKNYIASYKDMPITIYQMTRKYRDEIRPRGGILRGREFLMKDAYSFASNEEDAFASFQKLDDTYNKIFKDLKIPFVSAWADSGDIGGEFSKEFHLIHESGEDTLMSCKHCGDISTLDMSQSYPEKDGQYSGDVDCKYALTKDHSTLICFYYPKDRQLNWNLALNAMDKDIDLTLRNKPNDHVLQVYEKDNEDIMFSKILRVMDCRLNSKSNFPDFPLKKYLKNNFGQISDVSIVDAQENEICGKCEEGRLEPLKSIEVGHIFLLGNKYSKPLNVKFVDKENKNETFVHMGCYGIGVSRLVGAIAELGRDSNGFRWPAIMAPYKVSICTGPNNPENSQRLQDVKSELLNDPTMQNLQNDILDQFNEKLGIGARIKLSHAMGIPLCVIVGSKSWPNVEIEVRGIRWGEKDLWRKQFEKRCSELQWKCTKNEHGIEKHTVPIQHLAEVIGVLLKDM

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Acetylation	SLSNNTLKSETTQEL CCCCCCCCCHHHHHH	44.18	17397211
189	Acetylation	KLDDTYNKIFKDLKI HHHHHHHHHHHHCCC	38.82	24489116
319	Phosphorylation	DNEDIMFSKILRVMD CCHHHHHHHHHHHHH	11.04	17287358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYPM_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYPM_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYPM_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DBF2_YEAST	DBF2	genetic	27708008
POB3_YEAST	POB3	genetic	27708008
SPC24_YEAST	SPC24	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
SEC17_YEAST	SEC17	genetic	27708008
AAR2_YEAST	AAR2	genetic	27708008
ORC2_YEAST	ORC2	genetic	27708008
MAK5_YEAST	MAK5	genetic	27708008
NOP14_YEAST	NOP14	genetic	27708008
TIM22_YEAST	TIM22	genetic	27708008
CDC13_YEAST	CDC13	genetic	27708008
PCF11_YEAST	PCF11	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
HSF_YEAST	HSF1	genetic	27708008
NU145_YEAST	NUP145	genetic	27708008
MCE1_YEAST	CEG1	genetic	27708008
GPI10_YEAST	GPI10	genetic	27708008
BRR6_YEAST	BRR6	genetic	27708008
PRP18_YEAST	PRP18	genetic	27708008
RRP41_YEAST	SKI6	genetic	27708008
SLN1_YEAST	SLN1	genetic	27708008
TIM16_YEAST	PAM16	genetic	27708008
RFC2_YEAST	RFC2	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
FIP1_YEAST	FIP1	genetic	27708008
NNF1_YEAST	NNF1	genetic	27708008
YJ9I_YEAST	YJR141W	genetic	27708008
HYM1_YEAST	HYM1	genetic	27708008
SSL1_YEAST	SSL1	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
CDC45_YEAST	CDC45	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
MED11_YEAST	MED11	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008
NOG2_YEAST	NOG2	genetic	27708008
MED7_YEAST	MED7	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
CLP1_YEAST	CLP1	genetic	27708008
ULP1_YEAST	ULP1	genetic	27708008
GPI2_YEAST	GPI2	genetic	27708008
HRR25_YEAST	HRR25	genetic	27708008
IF6_YEAST	TIF6	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYPM_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-319, AND MASSSPECTROMETRY.	17287358 [Abstract]