dbPTM

PSF3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PSF3_YEAST
UniProt AC	Q12146
Protein Name	DNA replication complex GINS protein PSF3
Gene Name	PSF3 {ECO:0000312\|SGD:S000005506}
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	194
Subcellular Localization	Nucleus .
Protein Description	Functions as part of the GINS complex which plays an essential role in the initiation of DNA replication by binding to DNA replication origins and facilitating the assembly of the DNA replication machinery..
Protein Sequence	MGYYDIDDVLADGTEFPCKFQYDIPGLGYLENNPGRPITKNTKLSLPLWLARILAIVGGDEALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIMLFSEKELANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKSHESYKDTKRWMFKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	Ubiquitination	LNADSTGKNSANTNI CCCCCCCCCCCCCCC	48.06	19722269
155	Phosphorylation	ADSTGKNSANTNIAT CCCCCCCCCCCCCHH	26.78	28132839
168	Ubiquitination	ATSTFLLKLEEMEKE HHHHHHHHHHHHHHH	56.87	19722269

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PSF3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PSF3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PSF3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLD5_YEAST	SLD5	physical	16554755
PSA1_YEAST	SCL1	physical	16554755
PSA3_YEAST	PRE9	physical	16554755
CTF4_YEAST	CTF4	physical	19661920
SLD5_YEAST	SLD5	physical	19661920
PSF1_YEAST	PSF1	physical	19661920
PSF2_YEAST	PSF2	physical	19661920
SLD5_YEAST	SLD5	physical	24628792
PSF2_YEAST	PSF2	physical	24628792
DPB2_YEAST	DPB2	physical	24628792
SEC18_YEAST	SEC18	genetic	27708008
ARP2_YEAST	ARP2	genetic	27708008
COPA_YEAST	COP1	genetic	27708008
PSF1_YEAST	PSF1	genetic	27708008
FAL1_YEAST	FAL1	genetic	27708008
SLD5_YEAST	SLD5	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
ALG2_YEAST	ALG2	genetic	27708008
SLD3_YEAST	SLD3	genetic	27708008
ORC6_YEAST	ORC6	genetic	27708008
PSF2_YEAST	PSF2	genetic	27708008
DPB11_YEAST	DPB11	genetic	27708008
PRP19_YEAST	PRP19	genetic	27708008
ERG27_YEAST	ERG27	genetic	27708008
SC61A_YEAST	SEC61	genetic	27708008
HMCS_YEAST	ERG13	genetic	27708008
ARPC2_YEAST	ARC35	genetic	27708008
YAJ9_YEAST	YAR029W	genetic	27708008
VPS41_YEAST	VPS41	genetic	27708008
SWF1_YEAST	SWF1	genetic	27708008
SAC3_YEAST	SAC3	genetic	27708008
PMP3_YEAST	PMP3	genetic	27708008
PEF1_YEAST	PEF1	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
VPS29_YEAST	VPS29	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
SNX4_YEAST	SNX4	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
SAC1_YEAST	SAC1	genetic	27708008
VPS13_YEAST	VPS13	genetic	27708008
ERG6_YEAST	ERG6	genetic	27708008
VPS17_YEAST	VPS17	genetic	27708008
RU2A_YEAST	LEA1	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008
SRO7_YEAST	SRO7	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PSF3_YEAST

Related Literatures of Post-Translational Modification