IGO1_YEAST - dbPTM
IGO1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID IGO1_YEAST
UniProt AC P53897
Protein Name mRNA stability protein IGO1
Gene Name IGO1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 168
Subcellular Localization
Protein Description Required for TORC1 to properly control gene expression and chronological life span. Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway..
Protein Sequence MSNENLSPNSSNPDLTKLNNGESGTIDTSKFSPNEMKLYKMYGKLPSKKDIFKHTMQKRKYFDSGDYALQKAGIQNNDPINYGKNNLPLTNPSKLREDIIKRRISTCPSTASTAGVVDNATLIQKEGSISSGPPSSNNGTIGGGSTSSTPVGNHSSSSSSLYTESPIR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSNENLSPN
------CCCCCCCCC		53.5022369663
7Phosphorylation-MSNENLSPNSSNPD
-CCCCCCCCCCCCCC		33.3522369663
10PhosphorylationNENLSPNSSNPDLTK
CCCCCCCCCCCCHHC		34.5722369663
11PhosphorylationENLSPNSSNPDLTKL
CCCCCCCCCCCHHCC		60.0522369663
16PhosphorylationNSSNPDLTKLNNGES
CCCCCCHHCCCCCCC		40.6519795423
23PhosphorylationTKLNNGESGTIDTSK
HCCCCCCCCCCCCCC		42.5122369663
25PhosphorylationLNNGESGTIDTSKFS
CCCCCCCCCCCCCCC		25.5922369663
28PhosphorylationGESGTIDTSKFSPNE
CCCCCCCCCCCCHHH		29.9322369663
29PhosphorylationESGTIDTSKFSPNEM
CCCCCCCCCCCHHHH		28.1422369663
30AcetylationSGTIDTSKFSPNEMK
CCCCCCCCCCHHHHH		52.5324489116
32PhosphorylationTIDTSKFSPNEMKLY
CCCCCCCCHHHHHHH		30.4722369663
37SuccinylationKFSPNEMKLYKMYGK
CCCHHHHHHHHHHCC		42.3523954790
37AcetylationKFSPNEMKLYKMYGK
CCCHHHHHHHHHHCC		42.3524489116
40AcetylationPNEMKLYKMYGKLPS
HHHHHHHHHHCCCCC		35.7625381059
44AcetylationKLYKMYGKLPSKKDI
HHHHHHCCCCCHHHH		39.4725381059
53AcetylationPSKKDIFKHTMQKRK
CCHHHHHHHHHHHHH		38.2025381059
60AcetylationKHTMQKRKYFDSGDY
HHHHHHHHCCCCHHH		58.2524489116
61PhosphorylationHTMQKRKYFDSGDYA
HHHHHHHCCCCHHHH		19.3622890988
64PhosphorylationQKRKYFDSGDYALQK
HHHHCCCCHHHHHHH		24.5422369663
67PhosphorylationKYFDSGDYALQKAGI
HCCCCHHHHHHHHCC		16.8522890988
71AcetylationSGDYALQKAGIQNND
CHHHHHHHHCCCCCC		49.8124489116
94AcetylationLPLTNPSKLREDIIK
CCCCCHHHHHHHHHH		53.4724489116
105PhosphorylationDIIKRRISTCPSTAS
HHHHHHHHCCCCCCC		23.3428889911
106PhosphorylationIIKRRISTCPSTAST
HHHHHHHCCCCCCCC		26.5128889911
109PhosphorylationRRISTCPSTASTAGV
HHHHCCCCCCCCCCC		38.4628889911
110PhosphorylationRISTCPSTASTAGVV
HHHCCCCCCCCCCCC		15.1228132839
112PhosphorylationSTCPSTASTAGVVDN
HCCCCCCCCCCCCCC		20.9123749301
113PhosphorylationTCPSTASTAGVVDNA
CCCCCCCCCCCCCCE		25.6019779198
121PhosphorylationAGVVDNATLIQKEGS
CCCCCCEEEEEECCC		30.5628889911
128PhosphorylationTLIQKEGSISSGPPS
EEEEECCCCCCCCCC		22.0123749301
130PhosphorylationIQKEGSISSGPPSSN
EEECCCCCCCCCCCC		30.8219779198
131PhosphorylationQKEGSISSGPPSSNN
EECCCCCCCCCCCCC		54.3619823750
135PhosphorylationSISSGPPSSNNGTIG
CCCCCCCCCCCCCCC		49.1621440633
136PhosphorylationISSGPPSSNNGTIGG
CCCCCCCCCCCCCCC		39.8419779198
140PhosphorylationPPSSNNGTIGGGSTS
CCCCCCCCCCCCCCC		20.6921551504
145PhosphorylationNGTIGGGSTSSTPVG
CCCCCCCCCCCCCCC		28.5221440633
146PhosphorylationGTIGGGSTSSTPVGN
CCCCCCCCCCCCCCC		29.9421440633
147PhosphorylationTIGGGSTSSTPVGNH
CCCCCCCCCCCCCCC		33.6321440633
148PhosphorylationIGGGSTSSTPVGNHS
CCCCCCCCCCCCCCC		36.5019823750
149PhosphorylationGGGSTSSTPVGNHSS
CCCCCCCCCCCCCCC		23.0421551504
155PhosphorylationSTPVGNHSSSSSSLY
CCCCCCCCCCCCCCC		35.6020377248
156PhosphorylationTPVGNHSSSSSSLYT
CCCCCCCCCCCCCCC		27.0419823750
157PhosphorylationPVGNHSSSSSSLYTE
CCCCCCCCCCCCCCC		36.9420377248
158PhosphorylationVGNHSSSSSSLYTES
CCCCCCCCCCCCCCC		26.3721440633
159PhosphorylationGNHSSSSSSLYTESP
CCCCCCCCCCCCCCC		26.7219823750
160PhosphorylationNHSSSSSSLYTESPI
CCCCCCCCCCCCCCC		27.6125752575
162PhosphorylationSSSSSSLYTESPIR-
CCCCCCCCCCCCCC-		15.4820377248
163PhosphorylationSSSSSLYTESPIR--
CCCCCCCCCCCCC--		34.9721551504
165PhosphorylationSSSLYTESPIR----
CCCCCCCCCCC----		20.1621440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of IGO1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
64SPhosphorylation

17330950
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of IGO1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
H2B2_YEASTHTB2physical
11805837
SAHH_YEASTSAH1physical
11805837
CYPH_YEASTCPR1physical
11805837
ACE2_YEASTACE2physical
10688190
IGO2_YEASTIGO2genetic
20471941
ACT_YEASTACT1physical
20471941
ATE1_YEASTATE1physical
20471941
CLU_YEASTCLU1physical
20471941
H4_YEASTHHF1physical
20471941
HRK1_YEASTHRK1physical
20471941
HSC82_YEASTHSC82physical
20471941
H2B1_YEASTHTB1physical
20471941
ILV6_YEASTILV6physical
20471941
LSM12_YEASTLSM12physical
20471941
NOT4_YEASTMOT2physical
20471941
PBP1_YEASTPBP1physical
20471941
PBP4_YEASTPBP4physical
20471941
VDAC1_YEASTPOR1physical
20471941
PSP2_YEASTPSP2physical
20471941
RIM1_YEASTRIM1physical
20471941
RS18A_YEASTRPS18Aphysical
20471941
RS18B_YEASTRPS18Aphysical
20471941
RSP5_YEASTRSP5physical
20471941
SEC23_YEASTSEC23physical
20471941
SFP1_YEASTSFP1physical
20471941
HSP71_YEASTSSA1physical
20471941
HSP72_YEASTSSA2physical
20471941
HSP74_YEASTSSA4physical
20471941
SSB1_YEASTSSB1physical
20471941
SSB2_YEASTSSB2physical
20471941
HSP77_YEASTSSC1physical
20471941
DHH1_YEASTDHH1genetic
20471941
CCR4_YEASTCCR4genetic
20471941
XRN1_YEASTXRN1genetic
20471941
CCR4_YEASTCCR4genetic
21289492
DHH1_YEASTDHH1genetic
21289492
LSM1_YEASTLSM1genetic
21289492
LSM6_YEASTLSM6genetic
21289492
PAT1_YEASTPAT1genetic
21289492
PP2A1_YEASTPPH21genetic
23273919
2ABA_YEASTCDC55genetic
23273919
2ABA_YEASTCDC55physical
23273919
ALG5_YEASTALG5physical
23273919
2ABA_YEASTCDC55genetic
23792549
2ABA_YEASTCDC55physical
23861665
PP2A1_YEASTPPH21physical
23861665
TAP42_YEASTTAP42physical
23861665
RTS3_YEASTRTS3physical
23861665
SWE1_YEASTSWE1genetic
23861665
MPIP_YEASTMIH1genetic
23861665
RIM15_YEASTRIM15genetic
23861665
CDK1_YEASTCDC28genetic
23861665
ZDS1_YEASTZDS1genetic
23861665
ZDS2_YEASTZDS2genetic
23861665
ZDS1_YEASTZDS1genetic
24800822
AGP1_YEASTAGP1genetic
27708008
BDF2_YEASTBDF2genetic
27708008
SWF1_YEASTSWF1genetic
27708008
CWC15_YEASTCWC15genetic
27708008
MAL12_YEASTMAL12genetic
27708008
IGO2_YEASTIGO2genetic
27708008
MEH1_YEASTMEH1genetic
27708008
XDJ1_YEASTXDJ1genetic
27708008
DUS3_YEASTDUS3genetic
27708008
NU188_YEASTNUP188genetic
27708008
SUCA_YEASTLSC1genetic
27708008
2ABA_YEASTCDC55genetic
28600888
WHI5_YEASTWHI5genetic
28600888
STB1_YEASTSTB1genetic
28600888
2ABA_YEASTCDC55genetic
26356805
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of IGO1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-7; SER-10;SER-32; SER-64 AND SER-155, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.

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