FPPS_YEAST - dbPTM
FPPS_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FPPS_YEAST
UniProt AC P08524
Protein Name Farnesyl pyrophosphate synthase
Gene Name ERG20
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 352
Subcellular Localization Cytoplasm.
Protein Description Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate..
Protein Sequence MASEKEIRRERFLNVFPKLVEELNASLLAYGMPKEACDWYAHSLNYNTPGGKLNRGLSVVDTYAILSNKTVEQLGQEEYEKVAILGWCIELLQAYFLVADDMMDKSITRRGQPCWYKVPEVGEIAINDAFMLEAAIYKLLKSHFRNEKYYIDITELFHEVTFQTELGQLMDLITAPEDKVDLSKFSLKKHSFIVTFKTAYYSFYLPVALAMYVAGITDEKDLKQARDVLIPLGEYFQIQDDYLDCFGTPEQIGKIGTDIQDNKCSWVINKALELASAEQRKTLDENYGKKDSVAEAKCKKIFNDLKIEQLYHEYEESIAKDLKAKISQVDESRGFKADVLTAFLNKVYKRSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
46PhosphorylationWYAHSLNYNTPGGKL
HHHHHCCCCCCCCCC		26.2123749301
52AcetylationNYNTPGGKLNRGLSV
CCCCCCCCCCCCCEE		48.8024489116
52UbiquitinationNYNTPGGKLNRGLSV
CCCCCCCCCCCCCEE		48.8023749301
58PhosphorylationGKLNRGLSVVDTYAI
CCCCCCCEEHHHHHH		23.9530377154
184AcetylationEDKVDLSKFSLKKHS
CCCCCHHHHCCCCCE		46.3922865919
263UbiquitinationGTDIQDNKCSWVINK
CCCCCCCCHHHHHHH		37.6223749301
263AcetylationGTDIQDNKCSWVINK
CCCCCCCCHHHHHHH		37.6224489116
276PhosphorylationNKALELASAEQRKTL
HHHHHHCCHHHHHCH		44.9922369663
289AcetylationTLDENYGKKDSVAEA
CHHHHCCCCCHHHHH		42.9422865919
289SuccinylationTLDENYGKKDSVAEA
CHHHHCCCCCHHHHH		42.9423954790
292PhosphorylationENYGKKDSVAEAKCK
HHCCCCCHHHHHHHH		31.9127214570
297UbiquitinationKDSVAEAKCKKIFND
CCHHHHHHHHHHHHH		37.7823749301
300AcetylationVAEAKCKKIFNDLKI
HHHHHHHHHHHHHHH		63.1022865919
306AcetylationKKIFNDLKIEQLYHE
HHHHHHHHHHHHHHH		47.2424489116
317PhosphorylationLYHEYEESIAKDLKA
HHHHHHHHHHHHHHH		18.8624961812
320AcetylationEYEESIAKDLKAKIS
HHHHHHHHHHHHHHH		63.0224489116
325UbiquitinationIAKDLKAKISQVDES
HHHHHHHHHHHCCCC		41.1023749301
336UbiquitinationVDESRGFKADVLTAF
CCCCCCCCHHHHHHH		46.6423749301
336AcetylationVDESRGFKADVLTAF
CCCCCCCCHHHHHHH		46.6424489116
346UbiquitinationVLTAFLNKVYKRSK-
HHHHHHHHHHHHCC-		49.4417644757
346AcetylationVLTAFLNKVYKRSK-
HHHHHHHHHHHHCC-		49.4424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FPPS_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FPPS_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FPPS_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TBP7_YEASTYTA7physical
19416104
HIR3_YEASTHIR3physical
19416104
MED17_YEASTSRB4physical
19416104
COQ8_YEASTCOQ8physical
19416104
HAP1_YEASTHAP1physical
19416104
IDH1_YEASTIDH1genetic
21623372
ATPO_YEASTATP5genetic
21623372
PPT2_YEASTPPT2genetic
21623372
COX6_YEASTCOX6genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
THRC_YEASTTHR4genetic
21623372
ADK_YEASTADO1genetic
21623372
LCB5_YEASTLCB5genetic
21623372
IDH2_YEASTIDH2genetic
21623372
SUR1_YEASTSUR1genetic
21623372
PDE2_YEASTPDE2genetic
21623372
PHO87_YEASTPHO87genetic
21623372
SCS7_YEASTSCS7genetic
21623372
PSB1_YEASTPRE3genetic
23891562
PSB5_YEASTPRE2genetic
23891562
PSA4_YEASTPRE6genetic
23891562
PSA7_YEASTPRE10genetic
23891562
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FPPS_YEAST

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Related Literatures of Post-Translational Modification

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