| UniProt ID | COQ8_YEAST | |
|---|---|---|
| UniProt AC | P27697 | |
| Protein Name | Atypical kinase COQ8, mitochondrial {ECO:0000250|UniProtKB:Q8NI60} | |
| Gene Name | COQ8 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 501 | |
| Subcellular Localization |
Mitochondrion inner membrane Peripheral membrane protein Matrix side . |
|
| Protein Description | Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. [PubMed: 27499294 Affects the molecular organization and function of COQ3, possibly through kinase activity towards COQ3, COQ5 and/or COQ7] | |
| Protein Sequence | MVTNMVKLRNLRRLYCSSRLLRTIQNGRISSVSSISLSKKYTTKSAKEGEENVERKHEEEKKDTLKSSSVPTSRISRLFHYGSLAAGVGMNAAAKGISEVAKGNSPTWKSLILSDSNIDRITNKFSKMRGVALKIGQLLSFQDEKVLPKELYEILSRVQNSANHMPQRQLEKVMAKELGANWKTKFSKFDKIPMAAASIGQVHAAELPSGQRVVVKIQYPGVKESIDSDLNSLLMLLTASSLLPKGLFLDKTIANARTELKWECDYNREARALQKFEALLKDDPAFEVPHVFPEYTTDNIITMTRMEGTEIMKLPKASQETKNFISENIMRLCLEEIATFKYMQTDPNWANFLYNGRTKKIELLDFGASRPFAEDFILKYRKLLTYATLRDRKGAYEMSVQLGYLTGLESQSMKDAHVDSVLTLGEPFRGDVDKSFDFKDQTVSDRIRGNIGLMLNERLCPPPEETYSLHRKFSGIFLLCARMGASVHCAKLFKEIFAYKV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Acetylation | -MVTNMVKLRNLRRL -CCCCHHHHHHHHHH | 30.84 | 25381059 | |
| 62 | 2-Hydroxyisobutyrylation | RKHEEEKKDTLKSSS HHHHHHHHHHHHHCC | 60.26 | - | |
| 67 | Phosphorylation | EKKDTLKSSSVPTSR HHHHHHHHCCCCHHH | 30.84 | 26447709 | |
| 68 | Phosphorylation | KKDTLKSSSVPTSRI HHHHHHHCCCCHHHH | 33.49 | 26447709 | |
| 69 | Phosphorylation | KDTLKSSSVPTSRIS HHHHHHCCCCHHHHH | 38.93 | 26447709 | |
| 72 | Phosphorylation | LKSSSVPTSRISRLF HHHCCCCHHHHHHHH | 28.60 | 26447709 | |
| 73 | Phosphorylation | KSSSVPTSRISRLFH HHCCCCHHHHHHHHH | 22.88 | 26447709 | |
| 76 | Phosphorylation | SVPTSRISRLFHYGS CCCHHHHHHHHHHHH | 23.09 | 26447709 | |
| 81 | Phosphorylation | RISRLFHYGSLAAGV HHHHHHHHHHHHHHC | 10.90 | 26447709 | |
| 83 | Phosphorylation | SRLFHYGSLAAGVGM HHHHHHHHHHHHCCC | 13.99 | 26447709 | |
| 114 | Phosphorylation | TWKSLILSDSNIDRI CHHHHHHCCCCHHHH | 31.81 | 30377154 | |
| 116 | Phosphorylation | KSLILSDSNIDRITN HHHHHCCCCHHHHHH | 32.10 | 28889911 | |
| 191 | Acetylation | TKFSKFDKIPMAAAS CCCCCCCCCCCCHHH | 52.41 | 24489116 | |
| 238 | Phosphorylation | NSLLMLLTASSLLPK HHHHHHHHHHHCCCC | 22.11 | 28889911 | |
| 251 | Acetylation | PKGLFLDKTIANART CCCCCCCHHHHHCHH | 43.93 | 24489116 | |
| 275 | Acetylation | REARALQKFEALLKD HHHHHHHHHHHHHCC | 46.12 | 24489116 | |
| 410 | Phosphorylation | GYLTGLESQSMKDAH HCCCCCCCCCCHHCC | 32.37 | 27017623 | |
| 412 | Phosphorylation | LTGLESQSMKDAHVD CCCCCCCCCHHCCCC | 36.76 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of COQ8_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of COQ8_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of COQ8_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
