INV2_YEAST - dbPTM
INV2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID INV2_YEAST
UniProt AC P00724
Protein Name Invertase 2
Gene Name SUC2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 532
Subcellular Localization Isoform Intracellular: Cytoplasm.
Isoform Secreted: Secreted.
Protein Description
Protein Sequence MLLQAFLFLLAGFAAKISASMTNETSDRPLVHFTPNKGWMNDPNGLWYDEKDAKWHLYFQYNPNDTVWGTPLFWGHATSDDLTNWEDQPIAIAPKRNDSGAFSGSMVVDYNNTSGFFNDTIDPRQRCVAIWTYNTPESEEQYISYSLDGGYTFTEYQKNPVLAANSTQFRDPKVFWYEPSQKWIMTAAKSQDYKIEIYSSDDLKSWKLESAFANEGFLGYQYECPGLIEVPTEQDPSKSYWVMFISINPGAPAGGSFNQYFVGSFNGTHFEAFDNQSRVVDFGKDYYALQTFFNTDPTYGSALGIAWASNWEYSAFVPTNPWRSSMSLVRKFSLNTEYQANPETELINLKAEPILNISNAGPWSRFATNTTLTKANSYNVDLSNSTGTLEFELVYAVNTTQTISKSVFADLSLWFKGLEDPEEYLRMGFEVSASSFFLDRGNSKVKFVKENPYFTNRMSVNNQPFKSENDLSYYKVYGLLDQNILELYFNDGDVVSTNTYFMTTGNALGSVNMTTGVDNLFYIDKFQVREVK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
23N-linked_GlycosylationKISASMTNETSDRPL
HHHHHCCCCCCCCCC		41.743284881
64N-linked_GlycosylationLYFQYNPNDTVWGTP
EEEECCCCCCCCCCE		54.683284881
97N-linked_GlycosylationIAIAPKRNDSGAFSG
EEEECCCCCCCCCCC		54.663284881
111N-linked_GlycosylationGSMVVDYNNTSGFFN
CCEEEECCCCCCCCC		40.623284881
118N-linked_GlycosylationNNTSGFFNDTIDPRQ
CCCCCCCCCCCCHHH		43.163284881
165N-linked_GlycosylationKNPVLAANSTQFRDP
CCCEEEECCCCCCCC		39.733284881
167PhosphorylationPVLAANSTQFRDPKV
CEEEECCCCCCCCCE		31.3728889911
266N-linked_GlycosylationQYFVGSFNGTHFEAF
CEEEECCCCCEEEEE		57.033284881
275N-linked_GlycosylationTHFEAFDNQSRVVDF
CEEEEECCCCCEEEC		34.963284881
333PhosphorylationMSLVRKFSLNTEYQA
HHHHHHHCCCCCCCC		24.6030377154
356N-linked_GlycosylationLKAEPILNISNAGPW
CCCEECCCCCCCCCC		36.043284881
368PhosphorylationGPWSRFATNTTLTKA
CCCHHHCCCCCCCCC		30.3127017623
369N-linked_GlycosylationPWSRFATNTTLTKAN
CCHHHCCCCCCCCCE		27.863284881
370PhosphorylationWSRFATNTTLTKANS
CHHHCCCCCCCCCEE		20.8727017623
371PhosphorylationSRFATNTTLTKANSY
HHHCCCCCCCCCEEE		34.2027017623
373PhosphorylationFATNTTLTKANSYNV
HCCCCCCCCCEEEEC		26.4727017623
384N-linked_GlycosylationSYNVDLSNSTGTLEF
EEECCCCCCCCEEEE		51.383284881
398N-linked_GlycosylationFELVYAVNTTQTISK
EEEEEEEECCCEECH		29.273284881
432PhosphorylationLRMGFEVSASSFFLD
HHHCCEEEEHHEEEE		18.4227017623
443PhosphorylationFFLDRGNSKVKFVKE
EEEECCCCEEEEEEC		41.4727017623
466UbiquitinationSVNNQPFKSENDLSY
EECCCCCCCCCCCHH		64.6423749301
512N-linked_GlycosylationGNALGSVNMTTGVDN
CCCCCCEECCCCCCC		24.633284881
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of INV2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of INV2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of INV2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SDO1L_YEASTRTC3physical
16554755
MIG1_YEASTMIG1physical
17133623
GET3_YEASTGET3physical
18719252
ATH1_YEASTATH1genetic
19703229
ODPB_YEASTPDB1genetic
21623372
THDH_YEASTILV1genetic
21623372
COX10_YEASTCOX10genetic
21623372
ODP2_YEASTLAT1genetic
21623372
STU1_YEASTSTU1genetic
27708008
GPB2_YEASTGPB2genetic
27708008
DPO4_YEASTPOL4genetic
27708008
CRD1_YEASTCRD1genetic
27708008
FMP42_YEASTYMR221Cgenetic
27708008
ATP23_YEASTATP23genetic
27708008
TIM22_YEASTTIM22genetic
27708008
GPI10_YEASTGPI10genetic
27708008
ATC3_YEASTDRS2genetic
27708008
CACM_YEASTYAT1genetic
27708008
YBC9_YEASTYBL029Wgenetic
27708008
SHG1_YEASTSHG1genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RMT2_YEASTRMT2genetic
27708008
MPC2_YEASTMPC2genetic
27708008
STB5_YEASTSTB5genetic
27708008
GYP6_YEASTGYP6genetic
27708008
RPA34_YEASTRPA34genetic
27708008
RAD26_YEASTRAD26genetic
27708008
URA8_YEASTURA8genetic
27708008
ANR2_YEASTANR2genetic
27708008
YET2_YEASTYET2genetic
27708008
SIP5_YEASTSIP5genetic
27708008
RAD14_YEASTRAD14genetic
27708008
YM79_YEASTYMR244Wgenetic
27708008
LSM7_YEASTLSM7genetic
27708008
ENG1_YEASTDSE4genetic
27708008
RL7B_YEASTRPL7Bgenetic
27708008
SPEE_YEASTSPE3genetic
27708008
DOM34_YEASTDOM34genetic
29158977
SGTA_HUMANSGTAphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of INV2_YEAST

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Characterization of the glycosylation sites in yeast externalinvertase. I. N-linked oligosaccharide content of the individualsequons.";
Reddy V.A., Johnson R.S., Biemann K., Williams R.S., Ziegler F.D.,Trimble R.B., Maley F.;
J. Biol. Chem. 263:6978-6985(1988).
Cited for: PROTEIN SEQUENCE OF 21-532, AND GLYCOSYLATION AT ASN-23; ASN-64;ASN-97; ASN-111; ASN-118; ASN-165; ASN-266; ASN-275; ASN-356; ASN-369;ASN-384; ASN-398 AND ASN-512.

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