SEG1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SEG1_YEAST
• UniProt AC: Q04279
• Protein Name: Eisosome protein SEG1
• Gene Name: SEG1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 960
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to eisosomes.
• Protein Description: Important for the biogenesis of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. Required for efficient incorporation of the eisosome component PIL1 into eisosomes..
• Protein Sequence: MFRRRTTAPEMEQADPTAVAAAASIGKLLMKKGNQSDNEQRPTYRSASMTNLRKPSAPKRMSSISSISSESRRSDGKGRPGKINSLTQRSSMGKGDSLNSPLTKEPQHKTRSHNRTSSLPNQRGQQSRNSSGLQRQKSKTHQRISYDEAQRTFKDFGGPQARGILTGQHRTENPSGSIPLRTTRKYIPGPNGLVAIEVPVEKPSNANTSKLLRRSNSAHSALNARNGSLLRKKVSQESLHSQPKKTSSLGNTSSTQAKKGQKAVQERNLAKKHPINSNVPLIETQVREETDQELKLDNSNSSESETVVNSENNLEKPSSLNIEKDDLSKLIHENIELESFIEEKGKEKPLNSDQEDVFISEKTVKGDVQWPKNNRQASTLEKTFNYDNEEKREGNKPVAEHPLPEAEVDDKSVEQLNNISSSGSYSAQGSVENSKPENGNKNLENDTTSSPTQDLDEKSRSIEEKDTLEGTESSKKVEKPDNCCEKISGANTSSKKGNVGDTKDEFFDTVEESDQKTSKSNSSKNTDHSNQTEPTPSLAQYLRTSNTYLSRKNQSKQAEQEKFHKPEAPMVPVTKVVTPIKSALKKSSGSSNHDSSMYSDNSPANGAYLSLTTAENTRLNAQMTMSDSVSRRASLKRSSIKRPQSVGQFRSIRSNSPSPPEKINNKRHSAIPLGTPEKGKPKRNSVMASLSKNSQQIQEPASVYESNGPNKPKNQINKNIKRGSQIAQNNKPSTKDMNSILYPKEPPPRKSSFEKTRSNESHLGFKKLSLRNGNFEEALSESYNGQASQNSTNVNRTDTAQEFFKYLGHSSRFADSDSEDESQFFNQGPSKYNTETEGNKTSGNKNSNGGNGAFSLFKSKSKQKENNVVSPGVSSPNHTTTDPAITSKKVDKKFSGLSLRAASEAEPAKNSNPSMTNRLRFSSNPENGESRLPQAQEVSVTKEKKGSFGKKLKKIFGRKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MFRRRTTAPEMEQ --CCCCCCCCHHHHH		30377154
7	Phosphorylation	-MFRRRTTAPEMEQA -CCCCCCCCHHHHHC		29734811
43	Phosphorylation	SDNEQRPTYRSASMT CCCCCCCCCHHHHHH		24961812
46	Phosphorylation	EQRPTYRSASMTNLR CCCCCCHHHHHHCCC		22890988
48	Phosphorylation	RPTYRSASMTNLRKP CCCCHHHHHHCCCCC		22369663
50	Phosphorylation	TYRSASMTNLRKPSA CCHHHHHHCCCCCCC		22890988
62	Phosphorylation	PSAPKRMSSISSISS CCCCCCHHHCHHHCC		22369663
63	Phosphorylation	SAPKRMSSISSISSE CCCCCHHHCHHHCCC		22369663
65	Phosphorylation	PKRMSSISSISSESR CCCHHHCHHHCCCCC		22369663
66	Phosphorylation	KRMSSISSISSESRR CCHHHCHHHCCCCCC		22369663
68	Phosphorylation	MSSISSISSESRRSD HHHCHHHCCCCCCCC		22369663
69	Phosphorylation	SSISSISSESRRSDG HHCHHHCCCCCCCCC		22369663
71	Phosphorylation	ISSISSESRRSDGKG CHHHCCCCCCCCCCC		22369663
74	Phosphorylation	ISSESRRSDGKGRPG HCCCCCCCCCCCCCC		20377248
85	Phosphorylation	GRPGKINSLTQRSSM CCCCCCCHHHCHHCC		22369663
87	Phosphorylation	PGKINSLTQRSSMGK CCCCCHHHCHHCCCC		22369663
90	Phosphorylation	INSLTQRSSMGKGDS CCHHHCHHCCCCCCC		21440633
91	Phosphorylation	NSLTQRSSMGKGDSL CHHHCHHCCCCCCCC		22369663
94	Ubiquitination	TQRSSMGKGDSLNSP HCHHCCCCCCCCCCC		23749301
97	Phosphorylation	SSMGKGDSLNSPLTK HCCCCCCCCCCCCCC		23749301
100	Phosphorylation	GKGDSLNSPLTKEPQ CCCCCCCCCCCCCCC		25521595
116	Phosphorylation	KTRSHNRTSSLPNQR CCCCCCCCCCCCCHH		22890988
117	Phosphorylation	TRSHNRTSSLPNQRG CCCCCCCCCCCCHHH		22890988
118	Phosphorylation	RSHNRTSSLPNQRGQ CCCCCCCCCCCHHHH		22369663
127	Phosphorylation	PNQRGQQSRNSSGLQ CCHHHHCCCCCHHHH		19684113
131	Phosphorylation	GQQSRNSSGLQRQKS HHCCCCCHHHHHHHC		24909858
154	Acetylation	DEAQRTFKDFGGPQA HHHHHHHHHHCCCCC		24489116
215	Phosphorylation	TSKLLRRSNSAHSAL HHHHHHHHCHHHHHH		22369663
217	Phosphorylation	KLLRRSNSAHSALNA HHHHHHCHHHHHHHH		22369663
220	Phosphorylation	RRSNSAHSALNARNG HHHCHHHHHHHHCCC		22369663
228	Phosphorylation	ALNARNGSLLRKKVS HHHHCCCHHHHHHHC		23749301
235	Phosphorylation	SLLRKKVSQESLHSQ HHHHHHHCHHHHHCC		22369663
238	Phosphorylation	RKKVSQESLHSQPKK HHHHCHHHHHCCCCC		25521595
241	Phosphorylation	VSQESLHSQPKKTSS HCHHHHHCCCCCCCC		22369663
246	Phosphorylation	LHSQPKKTSSLGNTS HHCCCCCCCCCCCCC		22369663
247	Phosphorylation	HSQPKKTSSLGNTSS HCCCCCCCCCCCCCH		22369663
248	Phosphorylation	SQPKKTSSLGNTSST CCCCCCCCCCCCCHH		22369663
252	Phosphorylation	KTSSLGNTSSTQAKK CCCCCCCCCHHHHHH		22369663
253	Phosphorylation	TSSLGNTSSTQAKKG CCCCCCCCHHHHHHH		22369663
254	Phosphorylation	SSLGNTSSTQAKKGQ CCCCCCCHHHHHHHH		22369663
255	Phosphorylation	SLGNTSSTQAKKGQK CCCCCCHHHHHHHHH		22369663
290	Phosphorylation	ETQVREETDQELKLD ECHHHHHCCCCCCCC		22369663
299	Phosphorylation	QELKLDNSNSSESET CCCCCCCCCCCCCEE		22369663
301	Phosphorylation	LKLDNSNSSESETVV CCCCCCCCCCCEEEE		22369663
302	Phosphorylation	KLDNSNSSESETVVN CCCCCCCCCCEEEEC		22369663
304	Phosphorylation	DNSNSSESETVVNSE CCCCCCCCEEEECCC		20377248
306	Phosphorylation	SNSSESETVVNSENN CCCCCCEEEECCCCC		22369663
310	Phosphorylation	ESETVVNSENNLEKP CCEEEECCCCCCCCC		20377248
316	Ubiquitination	NSENNLEKPSSLNIE CCCCCCCCCCCCCCC		23749301
318	Phosphorylation	ENNLEKPSSLNIEKD CCCCCCCCCCCCCHH		20377248
319	Phosphorylation	NNLEKPSSLNIEKDD CCCCCCCCCCCCHHH		22369663
324	Ubiquitination	PSSLNIEKDDLSKLI CCCCCCCHHHHHHHH		23749301
328	Phosphorylation	NIEKDDLSKLIHENI CCCHHHHHHHHHHCC		28889911
339	Phosphorylation	HENIELESFIEEKGK HHCCCHHHHHHHHCC		22369663
352	Phosphorylation	GKEKPLNSDQEDVFI CCCCCCCCCCCCEEE		22369663
378	Phosphorylation	PKNNRQASTLEKTFN CCCCCCCHHHHHHCC		19823750
379	Phosphorylation	KNNRQASTLEKTFNY CCCCCCHHHHHHCCC		19823750
382	Acetylation	RQASTLEKTFNYDNE CCCHHHHHHCCCCCH		24489116
412	Phosphorylation	EAEVDDKSVEQLNNI HHHCCCCCHHHHHCC		22369663
421	Phosphorylation	EQLNNISSSGSYSAQ HHHHCCCCCCCCCCC		19779198
422	Phosphorylation	QLNNISSSGSYSAQG HHHCCCCCCCCCCCC		24961812
424	Phosphorylation	NNISSSGSYSAQGSV HCCCCCCCCCCCCCC		28889911
425	Phosphorylation	NISSSGSYSAQGSVE CCCCCCCCCCCCCCC		21440633
426	Phosphorylation	ISSSGSYSAQGSVEN CCCCCCCCCCCCCCC		21440633
430	Phosphorylation	GSYSAQGSVENSKPE CCCCCCCCCCCCCCC		28889911
434	Phosphorylation	AQGSVENSKPENGNK CCCCCCCCCCCCCCC		28889911
447	Phosphorylation	NKNLENDTTSSPTQD CCCCCCCCCCCCCCC		22890988
448	Phosphorylation	KNLENDTTSSPTQDL CCCCCCCCCCCCCCH		22890988
449	Phosphorylation	NLENDTTSSPTQDLD CCCCCCCCCCCCCHH		22369663
450	Phosphorylation	LENDTTSSPTQDLDE CCCCCCCCCCCCHHH		22369663
452	Phosphorylation	NDTTSSPTQDLDEKS CCCCCCCCCCHHHHH		22369663
458	Ubiquitination	PTQDLDEKSRSIEEK CCCCHHHHHCCHHHH		23749301
459	Phosphorylation	TQDLDEKSRSIEEKD CCCHHHHHCCHHHHH		22369663
461	Phosphorylation	DLDEKSRSIEEKDTL CHHHHHCCHHHHHHC		22369663
467	Phosphorylation	RSIEEKDTLEGTESS CCHHHHHHCCCCCCC		22369663
473	Phosphorylation	DTLEGTESSKKVEKP HHCCCCCCCCCCCCC		28889911
537	Phosphorylation	NQTEPTPSLAQYLRT CCCCCCHHHHHHHHH		28889911
545	Phosphorylation	LAQYLRTSNTYLSRK HHHHHHHHCCHHCHH		28889911
578	Phosphorylation	VPVTKVVTPIKSALK CCCEEEECCHHHHHH		20377248
587	Phosphorylation	IKSALKKSSGSSNHD HHHHHHHCCCCCCCC		27017623
590	Phosphorylation	ALKKSSGSSNHDSSM HHHHCCCCCCCCCCC		27017623
595	Phosphorylation	SGSSNHDSSMYSDNS CCCCCCCCCCCCCCC		27017623
599	Phosphorylation	NHDSSMYSDNSPANG CCCCCCCCCCCCCCC		27017623
602	Phosphorylation	SSMYSDNSPANGAYL CCCCCCCCCCCCCEE		23749301
610	Phosphorylation	PANGAYLSLTTAENT CCCCCEEEEEECCCH		27017623
628	Phosphorylation	AQMTMSDSVSRRASL EECCCCHHHHHHHHH		28889911
630	Phosphorylation	MTMSDSVSRRASLKR CCCCHHHHHHHHHCH		24909858
639	Phosphorylation	RASLKRSSIKRPQSV HHHHCHHHCCCCCCC		19779198
645	Phosphorylation	SSIKRPQSVGQFRSI HHCCCCCCCCCHHCH		25533186
651	Phosphorylation	QSVGQFRSIRSNSPS CCCCCHHCHHCCCCC		21440633
654	Phosphorylation	GQFRSIRSNSPSPPE CCHHCHHCCCCCCCH		22890988
656	Phosphorylation	FRSIRSNSPSPPEKI HHCHHCCCCCCCHHH		21082442
658	Phosphorylation	SIRSNSPSPPEKINN CHHCCCCCCCHHHCC		21551504
669	Phosphorylation	KINNKRHSAIPLGTP HHCCCCCCCCCCCCC		21440633
675	Phosphorylation	HSAIPLGTPEKGKPK CCCCCCCCCCCCCCC		22369663
685	Phosphorylation	KGKPKRNSVMASLSK CCCCCCHHHHHHHCC		19684113
689	Phosphorylation	KRNSVMASLSKNSQQ CCHHHHHHHCCCCHH		19684113
691	Phosphorylation	NSVMASLSKNSQQIQ HHHHHHHCCCCHHHC		28889911
702	Phosphorylation	QQIQEPASVYESNGP HHHCCCHHHHHCCCC		25704821
711	Ubiquitination	YESNGPNKPKNQINK HHCCCCCCCHHHHHH		23749301
724	Phosphorylation	NKNIKRGSQIAQNNK HHHHHHHHHHHHHCC		25704821
731	Ubiquitination	SQIAQNNKPSTKDMN HHHHHHCCCCCCCCC		23749301
739	Phosphorylation	PSTKDMNSILYPKEP CCCCCCCCCCCCCCC		21440633
751	Phosphorylation	KEPPPRKSSFEKTRS CCCCCCCCCCCCCCC		21440633
752	Phosphorylation	EPPPRKSSFEKTRSN CCCCCCCCCCCCCCC		17287358
756	Phosphorylation	RKSSFEKTRSNESHL CCCCCCCCCCCCCCC		19823750
758	Phosphorylation	SSFEKTRSNESHLGF CCCCCCCCCCCCCCE		19823750
761	Phosphorylation	EKTRSNESHLGFKKL CCCCCCCCCCCEEEE		17287358
799	Phosphorylation	TNVNRTDTAQEFFKY CCCCCCHHHHHHHHH		30377154
805	Acetylation	DTAQEFFKYLGHSSR HHHHHHHHHHCCCCC		24489116
806	Phosphorylation	TAQEFFKYLGHSSRF HHHHHHHHHCCCCCC		19823750
810	Phosphorylation	FFKYLGHSSRFADSD HHHHHCCCCCCCCCC		21551504
811	Phosphorylation	FKYLGHSSRFADSDS HHHHCCCCCCCCCCC		20377248
816	Phosphorylation	HSSRFADSDSEDESQ CCCCCCCCCCCCHHH		22369663
818	Phosphorylation	SRFADSDSEDESQFF CCCCCCCCCCHHHHH		22369663
822	Phosphorylation	DSDSEDESQFFNQGP CCCCCCHHHHHHCCC		22369663
830	Phosphorylation	QFFNQGPSKYNTETE HHHHCCCCCCCCCCC		22890988
855	Phosphorylation	NGGNGAFSLFKSKSK CCCCCCHHHHHCCCC		21440633
870	Phosphorylation	QKENNVVSPGVSSPN CCCCCCCCCCCCCCC		22369663
874	Phosphorylation	NVVSPGVSSPNHTTT CCCCCCCCCCCCCCC		22369663
875	Phosphorylation	VVSPGVSSPNHTTTD CCCCCCCCCCCCCCC		22369663
879	Phosphorylation	GVSSPNHTTTDPAIT CCCCCCCCCCCCCCC		20377248
880	Phosphorylation	VSSPNHTTTDPAITS CCCCCCCCCCCCCCC		22369663
881	Phosphorylation	SSPNHTTTDPAITSK CCCCCCCCCCCCCCC		22369663
886	Phosphorylation	TTTDPAITSKKVDKK CCCCCCCCCCCCCCC		22369663
887	Phosphorylation	TTDPAITSKKVDKKF CCCCCCCCCCCCCCC		22369663
895	Phosphorylation	KKVDKKFSGLSLRAA CCCCCCCCCCCCHHH		22369663
898	Phosphorylation	DKKFSGLSLRAASEA CCCCCCCCCHHHHHC		22369663
903	Phosphorylation	GLSLRAASEAEPAKN CCCCHHHHHCCCCCC		22369663
909	Ubiquitination	ASEAEPAKNSNPSMT HHHCCCCCCCCCCHH		23749301
911	Phosphorylation	EAEPAKNSNPSMTNR HCCCCCCCCCCHHHC		22369663
914	Phosphorylation	PAKNSNPSMTNRLRF CCCCCCCCHHHCCCC		22369663
916	Phosphorylation	KNSNPSMTNRLRFSS CCCCCCHHHCCCCCC		22369663
922	Phosphorylation	MTNRLRFSSNPENGE HHHCCCCCCCCCCCC		22369663
923	Phosphorylation	TNRLRFSSNPENGES HHCCCCCCCCCCCCC		22369663
930	Phosphorylation	SNPENGESRLPQAQE CCCCCCCCCCCCCEE		24961812
939	Phosphorylation	LPQAQEVSVTKEKKG CCCCEEEECCCCCCC		24961812
941	Phosphorylation	QAQEVSVTKEKKGSF CCEEEECCCCCCCCH		24961812

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SEG1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SEG1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SEG1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LSP1_YEAST	LSP1	physical	16554755
PIL1_YEAST	PIL1	physical	19269952
LSP1_YEAST	LSP1	physical	19269952
YCP4_YEAST	YCP4	physical	19269952
RL27A_YEAST	RPL27A	physical	19269952
RL27B_YEAST	RPL27B	physical	19269952
PMA1_YEAST	PMA1	physical	19269952
G3P3_YEAST	TDH3	physical	19269952
RS2_YEAST	RPS2	physical	19269952
RL17A_YEAST	RPL17A	physical	19269952
RL7A_YEAST	RPL7A	physical	19269952
RL10_YEAST	RPL10	physical	19269952
RS13_YEAST	RPS13	physical	19269952
MED5_YEAST	NUT1	genetic	20093466
XDJ1_YEAST	XDJ1	genetic	20093466
NST1_YEAST	NST1	genetic	20093466
RS10A_YEAST	RPS10A	genetic	20093466
PIL1_YEAST	PIL1	physical	22869600
LSP1_YEAST	LSP1	physical	22869600
EIS1_YEAST	EIS1	physical	22869600
YG3A_YEAST	YGR130C	physical	22869600
SEG2_YEAST	SEG2	physical	22869600
GLYC_YEAST	SHM2	physical	22869600
MSC3_YEAST	MSC3	physical	22869600
PLB3_YEAST	PLB3	genetic	27708008
CYC2_YEAST	CYC2	genetic	27708008
RLA1_YEAST	RPP1A	genetic	27708008
UME6_YEAST	UME6	genetic	27708008
UBP3_YEAST	UBP3	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
SDHX_YEAST	YJL045W	genetic	27708008
MSC1_YEAST	MSC1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.