MRX12_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MRX12_YEAST
• UniProt AC: P47084
• Protein Name: MIOREX complex component 12 {ECO:0000305|PubMed:25683707}
• Gene Name: MRX12 {ECO:0000303|PubMed:25683707}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 519
• Subcellular Localization: Mitochondrion .
• Protein Description: Component of MIOREX complexes, large expressome-like assemblies of ribosomes with factors involved in all the steps of post-transcriptional gene expression..
• Protein Sequence: MLRSLHSAATLSNKRFYSLISHSNRKNIIKKLLRHPSFDPIRHHLPEDITTIDPYSLSQNVIESLNKLEVPKKDAAMVHNMMIENLSDLDYGVATIHSNNLRDLDLKPSLPAIKQIIRNNPGRVQSSWELFTQYKASMENVPDELMEVVLEKIIKFDKAEKVDGKKSLTYQDLVRCLYLINHFSSNYNLPSELVEPILIYIVDNGIPNVLGSVLKYKIPLSFFDKYVSEMTQYQICELYDFYSLDNIVADPLVLHKCLTVLGENEKIQQTEEEKEIISKLEEEIDIVKSQCHDNWSLEFPNWSVRKTATSFEELFLEIQKRNIDKKDFELAHKLLRLIGAFKGKVSLFFKLYDEYLLKFKNNEDDLMFEAFLTLCCQGYKSSNEKMLQYAEAFIKEDFDSKLESKIQSVLIVANAKANIDLSLKIYNSNISTAKREKDKYTDLAESDVLTESLILAFLSRDDADFARVIFDGALGEKLISGPTAAKKIKNLLAQYGEALETKTSKQVMQTKIEHYMESI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Phosphorylation	KKLLRHPSFDPIRHH HHHHCCCCCCCHHHC		30377154
109	Phosphorylation	RDLDLKPSLPAIKQI CCCCCCCCCHHHHHH		27017623
358	Acetylation	LYDEYLLKFKNNEDD HHHHHHHHCCCCCCH		24489116
426	Phosphorylation	IDLSLKIYNSNISTA EEEEEEEECCCCCHH		29734811
428	Phosphorylation	LSLKIYNSNISTAKR EEEEEECCCCCHHHH		29734811
431	Phosphorylation	KIYNSNISTAKREKD EEECCCCCHHHHHHH		29734811
477	Acetylation	FDGALGEKLISGPTA HCCHHHHHHHCCHHH		24489116
515	Phosphorylation	MQTKIEHYMESI--- HHHHHHHHHHCC---		27017623
518	Phosphorylation	KIEHYMESI------ HHHHHHHCC------		27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MRX12_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MRX12_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MRX12_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ATG17_YEAST	ATG17	physical	18719252
VPS4_YEAST	VPS4	physical	18719252
ADA2_YEAST	ADA2	physical	18719252
DIG1_YEAST	DIG1	physical	18719252
MDV1_YEAST	MDV1	physical	18719252
DIG2_YEAST	DIG2	physical	18719252
RV161_YEAST	RVS161	genetic	20093466
PEX19_YEAST	PEX19	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
MED5_YEAST	NUT1	genetic	20093466
YG1D_YEAST	YGR021W	genetic	20093466
RS27B_YEAST	RPS27B	genetic	20093466
NST1_YEAST	NST1	genetic	20093466
MED9_YEAST	CSE2	genetic	20093466
YO08A_YEAST	YOR008C-A	genetic	20093466
DFG16_YEAST	DFG16	genetic	20093466
VAM3_YEAST	VAM3	genetic	20093466
ELP4_YEAST	ELP4	genetic	20093466
MED1_YEAST	MED1	genetic	20093466
AGP1_YEAST	AGP1	genetic	27708008
RV161_YEAST	RVS161	genetic	27708008
PEX19_YEAST	PEX19	genetic	27708008
INO2_YEAST	INO2	genetic	27708008
PMP3_YEAST	PMP3	genetic	27708008
MED5_YEAST	NUT1	genetic	27708008
ASK10_YEAST	ASK10	genetic	27708008
BUB1_YEAST	BUB1	genetic	27708008
RAS2_YEAST	RAS2	genetic	27708008
PEX15_YEAST	PEX15	genetic	27708008
YO08A_YEAST	YOR008C-A	genetic	27708008
SFM1_YEAST	SFM1	genetic	27708008
VAM3_YEAST	VAM3	genetic	27708008
MED1_YEAST	MED1	genetic	27708008
HDA3_YEAST	HDA3	genetic	27708008
NDC80_HUMAN	NDC80	physical	27107014
CEP55_HUMAN	CEP55	physical	27107014
CEP63_HUMAN	CEP63	physical	27107014
CEP70_HUMAN	CEP70	physical	27107014
MTUS2_HUMAN	MTUS2	physical	27107014
IKZF1_HUMAN	IKZF1	physical	27107014
BACD2_HUMAN	TNFAIP1	physical	27107014
MNS1_HUMAN	MNS1	physical	27107014
GMCL1_HUMAN	GMCL1	physical	27107014
CDC23_HUMAN	CDC23	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.