MNS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MNS1_HUMAN
• UniProt AC: Q8NEH6
• Protein Name: Meiosis-specific nuclear structural protein 1
• Gene Name: MNS1
• Organism: Homo sapiens (Human).
• Sequence Length: 495
• Subcellular Localization: Nucleus.
• Protein Description: May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis..
• Protein Sequence: MGSKRRNLSCSERHQKLVDENYCKKLHVQALKNVNSQIRNQMVQNENDNRVQRKQFLRLLQNEQFELDMEEAIQKAEENKRLKELQLKQEEKLAMELAKLKHESLKDEKMRQQVRENSIELRELEKKLKAAYMNKERAAQIAEKDAIKYEQMKRDAEIAKTMMEEHKRIIKEENAAEDKRNKAKAQYYLDLEKQLEEQEKKKQEAYEQLLKEKLMIDEIVRKIYEEDQLEKQQKLEKMNAMRRYIEEFQKEQALWRKKKREEMEEENRKIIEFANMQQQREEDRMAKVQENEEKRLQLQNALTQKLEEMLRQREDLEQVRQELYQEEQAEIYKSKLKEEAEKKLRKQKEMKQDFEEQMALKELVLQAAKEEEENFRKTMLAKFAEDDRIELMNAQKQRMKQLEHRRAVEKLIEERRQQFLADKQRELEEWQLQQRRQGFINAIIEEERLKLLKEHATNLLGYLPKGVFKKEDDIDLLGEEFRKVYQQRSEICEEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
161	Phosphorylation	RDAEIAKTMMEEHKR HHHHHHHHHHHHHHH	16.84	-
188	Phosphorylation	NKAKAQYYLDLEKQL HHHHHHHHHHHHHHH	5.01	-
333	Acetylation	EEQAEIYKSKLKEEA HHHHHHHHHHHHHHH	46.94	20167786
335	Acetylation	QAEIYKSKLKEEAEK HHHHHHHHHHHHHHH	60.47	20167786
377	Acetylation	EEEENFRKTMLAKFA HHHHHHHHHHHHHHH	33.86	70749
378	Phosphorylation	EEENFRKTMLAKFAE HHHHHHHHHHHHHHH	17.11	24719451
462	Phosphorylation	HATNLLGYLPKGVFK HHHHHHHCCCCCCCC	21.57	-
485	Phosphorylation	GEEFRKVYQQRSEIC HHHHHHHHHHHHHHH	11.27	29116813

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MNS1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MNS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MNS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
MNS1_HUMAN	MNS1	physical	25416956
HSF1_HUMAN	HSF1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.