FOLD_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FOLD_YEAST
• UniProt AC: Q12676
• Protein Name: Dihydrofolate synthetase
• Gene Name: FOL3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 427
• Subcellular Localization: Cytoplasm .
• Protein Description: Glutamate-adding enzyme which catalyzes the binding of the first glutamyl side chain to dihydropteroate. Leads to the de nove synthesis of tetrahydrofolate..
• Protein Sequence: MAIELGLSRITKLLEHLGNPQNSLRVLHIAGTNGKGSVCTYLSSVLQQKSYQIGKFTTPHLVHVTDSITINNKPIPLERYQNIRLQLEALNKSHSLKCTEFELLTCTAFKYFYDVQCQWCVIEVGLGGRLDATNVIPGANKACCGITKISLDHESFLGNTLSEISKEKAGIITEGVPFTVIDGTNEASVINVVKERCKALGSELSVTDSQLNGNMIDTNSWGCFDLAKLPLNGEYQIFNLRVAMGMLDYLQMNELIDITKNEVSTRLAKVDWPGRLYRMDYRFDKVSNRTVPILMDGAHNGSAAVELVKYLRKEYGNQPLTFVMAVTHGKNLEPLLQPLLRPIDQVILTRFNNVEGMPWIHATDPEEIKDFILTQGYTKEIVIENDLHQVLPSLAHVSDEQRRPIVVCGSLYLCGELLRIHNSHLRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Acetylation	LGLSRITKLLEHLGN HHHHHHHHHHHHCCC	49.02	24489116
160	Phosphorylation	HESFLGNTLSEISKE CHHHHCCHHHHHHHH	29.84	26447709
162	Phosphorylation	SFLGNTLSEISKEKA HHHCCHHHHHHHHHC	30.74	26447709
165	Phosphorylation	GNTLSEISKEKAGII CCHHHHHHHHHCCCE	30.61	26447709
166	Acetylation	NTLSEISKEKAGIIT CHHHHHHHHHCCCEE	69.74	24489116
269	Acetylation	EVSTRLAKVDWPGRL CCCHHEECCCCCCCE	45.37	24489116
309	Acetylation	SAAVELVKYLRKEYG HHHHHHHHHHHHHHC	51.71	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FOLD_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FOLD_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FOLD_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KPC1_YEAST	PKC1	physical	16554755
CDC73_YEAST	CDC73	physical	16554755
FOLC_YEAST	RMA1	genetic	18408719

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.