RIB4_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIB4_YEAST
• UniProt AC: P50861
• Protein Name: 6,7-dimethyl-8-ribityllumazine synthase
• Gene Name: RIB4
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 169
• Subcellular Localization: Mitochondrion intermembrane space .
• Protein Description: Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin..
• Protein Sequence: MAVKGLGKPDQVYDGSKIRVGIIHARWNRVIIDALVKGAIERMASLGVEENNIIIETVPGSYELPWGTKRFVDRQAKLGKPLDVVIPIGVLIKGSTMHFEYISDSTTHALMNLQEKVDMPVIFGLLTCMTEEQALARAGIDEAHSMHNHGEDWGAAAVEMAVKFGKNAF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Acetylation	MAVKGLGKPDQVYDG CCCCCCCCCCCEECC	50.92	25381059
17	Acetylation	DQVYDGSKIRVGIIH CCEECCCEEEEEEEE	39.81	24489116
69	Ubiquitination	YELPWGTKRFVDRQA EECCCCCHHHHHCHH	39.64	24961812
80	Ubiquitination	DRQAKLGKPLDVVIP HCHHHHCCCCEEEEE	53.49	24961812
80	Acetylation	DRQAKLGKPLDVVIP HCHHHHCCCCEEEEE	53.49	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIB4_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIB4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIB4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIB4_YEAST	RIB4	physical	18719252

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.