dbPTM

SYYM_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SYYM_YEAST
UniProt AC	P48527
Protein Name	Tyrosine--tRNA ligase, mitochondrial
Gene Name	MSY1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	492
Subcellular Localization	Mitochondrion matrix .
Protein Description	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)..
Protein Sequence	MLELRSCSNLVNSSRRLVPLVTYSGLSAITLPKSRFYSQPSALEVQGTSDSRSDNILDELKQRGLVSQVSQPESFLRTKLNGNDKIKLYCGVDPTAQSLHLGNLVPLMVLLHFYVKGHDIVTVIGGATGKVGDPSGRKTERDVMENDIRQSNVASISQQLQRFFKNGLEYYRNRCALTEDVPSGKYTPRNNFNWWKDIKMLDFLADFGRHIRVQSMLARDSISSRLQTKNGLGFNEFTYQVLQAYDFYHLYKEENVTIQVGGNDQWGNITAGIDLINRIQPIKNKGLPFGITVPLLTTATGEKFGKSAGNAVFIDPSINTAYDVYQFFYNTLDADVPKFLKIFTFLNSSEIKKIVETHIKSPSLRYGQTLLAKEVTDMLYGVGSGSDSEALSNIIFGRYDGTLSAAKLVDLCKKARILQYADREIDLIKLICKLVNCSVSEARRKLSQGSVYLHHSKSKVNENISNLAPFLIDDRVLILRIGKQKCFIIEMR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
438	Phosphorylation	ICKLVNCSVSEARRK HHHHHCCCHHHHHHH	24.39	28889911
440	Phosphorylation	KLVNCSVSEARRKLS HHHCCCHHHHHHHHH	14.83	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SYYM_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SYYM_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SYYM_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ECM11_YEAST	ECM11	genetic	27708008
DCV1_YEAST	DCV1	genetic	27708008
KIP3_YEAST	KIP3	genetic	27708008
GEM1_YEAST	GEM1	genetic	27708008
AGP2_YEAST	AGP2	genetic	27708008
RIM1_YEAST	RIM1	genetic	27708008
QRI7_YEAST	QRI7	genetic	27708008
LCL3_YEAST	LCL3	genetic	27708008
YG21_YEAST	YGR053C	genetic	27708008
AVL9_YEAST	AVL9	genetic	27708008
AEP2_YEAST	AEP2	genetic	27708008
BIO5_YEAST	BIO5	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SYYM_YEAST

Related Literatures of Post-Translational Modification