dbPTM

AEP3_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	AEP3_YEAST
UniProt AC	Q12089
Protein Name	ATPase expression protein 3
Gene Name	AEP3
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	606
Subcellular Localization	Mitochondrion inner membrane Peripheral membrane protein Matrix side .
Protein Description	Required for respiration. Stabilizes the mitochondrial bicistronic mRNA encoding ATP6 and ATP8, 2 subunits of the proton-translocating ATP synthase..
Protein Sequence	MNTLRCLTQALSKSGREAPKLYQKVIFPGLFREGIPIANVKKVDEKIIDSPTSTSVNGEAKKIVRHGVKYEREQVKEYLSSLPTLTLSRKQIRDDYDEERAKRMYMFSKQTNSSNKFQKLLTAKSQEFTRELLTLLIDCTSNEKNSGPERFTRKFLKFSNDEIPPLPDFSKNPQLFENYIGILSHTKFNFRSSSKLNGIVRKMLRHLLHPTNKTTLPLRSAQVYNDSIYFFSEHFDFASCREIFAQMKAEGTKPNTITFNLLLRNVVKNSHIRKTKHPDDEVLFYLRSMRNHGVFADVITWTTCYNFLRDEVSRQLYIVQMGEHLGNFNVNFVYTVLRNGDYRAEDCLKVLAANSLPISRKTFYLCIERLLNEEQLETASKLLDYGFQHLKSNFKLDSEAMNHFMRVFANKGRSDLAFLCYNTCRKIYKIKPDSQTFEMLFKALVRNGNTKNFGAVLQYIKDLKVSEGFGLRTSYWRTKADSIFKFGSPNTLSEKSIEKARKLLGNLIASEGEFSWKIWKESDSSQKKILRFLGCIPTTLRCTNTAQDHQKPTNLPSNISQKKREYRNRVKAIATKAALEKRMAYIKDNDVAFKKELVKRRIVGEV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
482	Phosphorylation	YWRTKADSIFKFGSP EEECCCCHHHCCCCC	34.48	27017623
488	Phosphorylation	DSIFKFGSPNTLSEK CHHHCCCCCCCCCHH	20.36	27017623
496	Phosphorylation	PNTLSEKSIEKARKL CCCCCHHHHHHHHHH	31.74	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of AEP3_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of AEP3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of AEP3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MRM2_YEAST	MRM2	genetic	19061648
IF2A_YEAST	SUI2	genetic	19061648
TAH1_YEAST	TAH1	genetic	19061648
RS8A_YEAST	RPS8A	genetic	19061648
RS8B_YEAST	RPS8A	genetic	19061648
IF2P_YEAST	FUN12	physical	19843529
C1TM_YEAST	MIS1	physical	19843529
SWC4_YEAST	SWC4	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
IPYR_YEAST	IPP1	genetic	27708008
POP7_YEAST	POP7	genetic	27708008
MCES_YEAST	ABD1	genetic	27708008
SCC1_YEAST	MCD1	genetic	27708008
TECR_YEAST	TSC13	genetic	27708008
SLU7_YEAST	SLU7	genetic	27708008
SRPR_YEAST	SRP101	genetic	27708008
PSB3_YEAST	PUP3	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
CCA1_YEAST	CCA1	genetic	27708008
YPT1_YEAST	YPT1	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
PRS8_YEAST	RPT6	genetic	27708008
MCE1_YEAST	CEG1	genetic	27708008
XPO1_YEAST	CRM1	genetic	27708008
TIM16_YEAST	PAM16	genetic	27708008
CWC16_YEAST	YJU2	genetic	27708008
SYFB_YEAST	FRS1	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
APC2_YEAST	APC2	genetic	27708008
BET5_YEAST	BET5	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
ARPC2_YEAST	ARC35	genetic	27708008
MED7_YEAST	MED7	genetic	27708008
PROF_YEAST	PFY1	genetic	27708008
PRS10_YEAST	RPT4	genetic	27708008
MRX5_YEAST	YJL147C	genetic	28404747
ATP8_YEAST	ATP8	genetic	28404747
NRD1_YEAST	NRD1	genetic	28404747

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of AEP3_YEAST

Related Literatures of Post-Translational Modification