DLD2_YEAST - dbPTM
DLD2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DLD2_YEAST
UniProt AC P46681
Protein Name D-2-hydroxyglutarate--pyruvate transhydrogenase DLD2 {ECO:0000305}
Gene Name DLD2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 530
Subcellular Localization Mitochondrion matrix .
Protein Description Catalyzes the reversible oxidation of (R)-2-hydroxyglutarate to 2-oxoglutarate coupled to reduction of pyruvate to (R)-lactate. Can also use oxaloacetate as electron acceptor instead of pyruvate producing (R)-malate. [PubMed: 26774271 In addition to its enzymatic role it could play an important role in the yeast cell morphology]
Protein Sequence MLRNILVRSTGSNFKFAGRYMKSSALLGYYRRVNYYSTKIQTRLTSENYPDVHRDPRFKKLTSDDLNYFKSILSEQEILRASESEDLSFYNEDWMRKYKGQSKLVLRPKSVEKVSLILNYCNDEKIAVVPQGGNTGLVGGSVPIFDELILSLANLNKIRDFDPVSGILKCDAGVILENANNYVMEQNYMFPLDLGAKGSCHVGGVVATNAGGLRLLRYGSLHGSVLGLEVVMPNGQIVNSMHSMRKDNTGYDLKQLFIGSEGTIGIITGVSILTVPKPKAFNVSYLSVESFEDVQKVFVRARQELSEILSAFEFMDAKSQVLAKSQLKDAAFPLEDEHPFYILIETSGSNKDHDDSKLETFLENVMEEGIVTDGVVAQDETELQNLWKWREMIPEASQANGGVYKYDVSLPLKDLYSLVEATNARLSEAELVGDSPKPVVGAIGYGHVGDGNLHLNVAVREYNKNIEKTLEPFVYEFVSSKHGSVSAEHGLGFQKKNYIGYSKSPEEVKMMKDLKVHYDPNGILNPYKYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
249PhosphorylationHSMRKDNTGYDLKQL
HHCCCCCCCCCHHHE		47.4527214570
319PhosphorylationFEFMDAKSQVLAKSQ
HHHCCHHHHHHHHHH		27.5219823750
325PhosphorylationKSQVLAKSQLKDAAF
HHHHHHHHHHCCCCC		34.8319823750
468AcetylationEYNKNIEKTLEPFVY
HHHHCHHHHHHHHHH		55.3924489116
503AcetylationKNYIGYSKSPEEVKM
CCCCCCCCCHHHHHH		62.6425381059
509AcetylationSKSPEEVKMMKDLKV
CCCHHHHHHHHCCEE		36.2325381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DLD2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DLD2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DLD2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACT_YEASTACT1physical
15249227
ACT_YEASTACT1physical
15158445
ACT_YEASTACT1physical
15351742
RV167_YEASTRVS167genetic
20093466
ZRT1_YEASTZRT1genetic
20093466
MKS1_YEASTMKS1genetic
20093466
MED9_YEASTCSE2genetic
20093466
BUD21_YEASTBUD21genetic
20093466
LGE1_YEASTLGE1genetic
20093466
CSG2_YEASTCSG2genetic
21623372
QCR8_YEASTQCR8genetic
21623372
LCB5_YEASTLCB5genetic
21623372
MRM2_YEASTMRM2genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
RV161_YEASTRVS161genetic
27708008
MSH3_YEASTMSH3genetic
27708008
HNT2_YEASTHNT2genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
RV167_YEASTRVS167genetic
27708008
SMF2_YEASTSMF2genetic
27708008
UBX2_YEASTUBX2genetic
27708008
MKS1_YEASTMKS1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
IDH2_YEASTIDH2genetic
27708008
RS10A_YEASTRPS10Agenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DLD2_YEAST

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Related Literatures of Post-Translational Modification

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