dbPTM

TBCB_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBCB_YEAST
UniProt AC	P53904
Protein Name	Tubulin-specific chaperone B
Gene Name	ALF1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	254
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton. Microtubule-associated.
Protein Description	Acts to sequester alpha-tubulin from interaction with beta-tubulin, raising the possibility that it plays a regulatory role in the formation of the tubulin heterodimer..
Protein Sequence	MVRVVIESELVRTEKELPNSLKLRQFKDRLYHVTGVEPEDMEIVVKRQYDNKEIYSTKKGGAYSNEDEDANFLKGEEELIVVVTDSNAQSISNQLATQAEGIPSMEVISEEDYLRRDQSVLRWKMAHGYGRFNAAQQSQRAALAKQDEAYAREQLTAAIGRHCRVTVDGSAPREAILRYVGPLPLDVMGTWCGVEFPEAAGKNDGRINGVTLFGPVAPGHGSFVRPRAVEILSKDEESAEVEDVHDDVESDDEI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
250	Phosphorylation	DVHDDVESDDEI--- CCCCCCCCCCCC---	50.65	19795423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TBCB_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TBCB_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBCB_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TBA1_YEAST	TUB1	physical	9885248
TBA3_YEAST	TUB3	physical	9885248
TCPE_YEAST	CCT5	physical	9885248
BIK1_YEAST	BIK1	genetic	9885248
PAC2_YEAST	PAC2	genetic	9885248
TBCA_YEAST	RBL2	genetic	9885248
TBA3_YEAST	TUB3	genetic	9885248
CIN1_YEAST	CIN1	genetic	9885248
HDA1_YEAST	HDA1	genetic	21288874
HDA2_YEAST	HDA2	genetic	21288874
SUM1_YEAST	SUM1	genetic	22285862
YPK9_YEAST	YPK9	genetic	22457822
CDC1_YEAST	CDC1	genetic	27708008
RRP4_YEAST	RRP4	genetic	27708008
PRS7_YEAST	RPT1	genetic	27708008
MED14_YEAST	RGR1	genetic	27708008
CDS1_YEAST	CDS1	genetic	27708008
CDC48_YEAST	CDC48	genetic	27708008
TAF12_YEAST	TAF12	genetic	27708008
RMRP_YEAST	SNM1	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
HSF_YEAST	HSF1	genetic	27708008
BRR6_YEAST	BRR6	genetic	27708008
PRP18_YEAST	PRP18	genetic	27708008
TAF1_YEAST	TAF1	genetic	27708008
CP51_YEAST	ERG11	genetic	27708008
MPPA_YEAST	MAS2	genetic	27708008
BRL1_YEAST	BRL1	genetic	27708008
DNA2_YEAST	DNA2	genetic	27708008
SPC97_YEAST	SPC97	genetic	27708008
HACD_YEAST	PHS1	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
CDC11_YEAST	CDC11	genetic	27708008
SYFB_YEAST	FRS1	genetic	27708008
PGA3_YEAST	PGA3	genetic	27708008
TAF4_YEAST	TAF4	genetic	27708008
RNA1_YEAST	RNA1	genetic	27708008
NOP8_YEAST	NOP8	genetic	27708008
TOA1_YEAST	TOA1	genetic	27708008
SEC62_YEAST	SEC62	genetic	27708008
DIB1_YEAST	DIB1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBCB_YEAST

Related Literatures of Post-Translational Modification