COS8_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COS8_YEAST
• UniProt AC: P38723
• Protein Name: Protein COS8
• Gene Name: COS8
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 381
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Sequence: MKENEVKDEKSVDVLSFKQLEFQKTVLPQDVFRNELTWFCYEIYKSLAFRIWMLLWLPLSVWWKLSSNWIHPLIVSLLVLFLGPFFVLVICGLSRKRSLSKQLIQFCKEITEDTPSSDPHDWEVVAANLNSYFYENKTWNTKYFFFNAMSCQKAFKTTLLEPFSLKKDESAKVKSFKDSVPYIEEALQVYAAGFDKEWKLFNTEKEESPFDLEDIQLPKEAYRFKLTWILKRIFNLRCLPLFLYYFLIVYTSGNADLISRFLFPVVMFFIMTRDFQNMRMIVLSVKMEHKMQFLSTIINEQESGANGWDEIAKKMNRYLFEKKVWNNEEFFYDGLDCEWFFRRFFYRLLSLKKPMWFASLNVELWPYIKEAQSARNEKPLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	ENEVKDEKSVDVLSF CCCCCCCCCCCEEEH	66.95	24961812
11	Phosphorylation	NEVKDEKSVDVLSFK CCCCCCCCCCEEEHH	22.85	21440633
16	Phosphorylation	EKSVDVLSFKQLEFQ CCCCCEEEHHHHEEC	30.19	22369663
111	Phosphorylation	IQFCKEITEDTPSSD HHHHHHHHCCCCCCC	28.97	25704821
170	Phosphorylation	FSLKKDESAKVKSFK CCCCCCCCCCCCCHH	43.45	27017623
205	Ubiquitination	WKLFNTEKEESPFDL EECCCCCCCCCCCCH	65.82	23749301
208	Phosphorylation	FNTEKEESPFDLEDI CCCCCCCCCCCHHHC	31.77	27214570

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COS8_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COS8_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COS8_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CP51_YEAST	ERG11	physical	18467557
YAJ3_YEAST	YAR023C	physical	16093310
MST28_YEAST	MST28	physical	16093310
MST27_YEAST	MST27	physical	16093310
PHO88_YEAST	PHO88	physical	16093310
ALG1_YEAST	ALG1	physical	16093310
MKAR_YEAST	IFA38	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
YCV1_YEAST	YCR061W	physical	16093310
TECR_YEAST	TSC13	physical	16093310
SHR3_YEAST	SHR3	physical	16093310
SHO1_YEAST	SHO1	physical	16093310
RT23_YEAST	RSM23	physical	16093310
ERV29_YEAST	ERV29	physical	16093310
MAL11_YEAST	MAL11	physical	16093310
LAG1_YEAST	LAG1	physical	16093310
VATO_YEAST	VMA16	physical	16093310
YHU0_YEAST	YHR140W	physical	16093310
CHS7_YEAST	CHS7	physical	16093310
SNL1_YEAST	SNL1	physical	16093310
OST1_YEAST	OST1	physical	16093310
GWT1_YEAST	GWT1	physical	16093310
PRM10_YEAST	PRM10	physical	16093310
PHO86_YEAST	PHO86	physical	16093310
ELO1_YEAST	ELO1	physical	16093310
STE24_YEAST	STE24	physical	16093310
AUR1_YEAST	AUR1	physical	16093310
LAC1_YEAST	LAC1	physical	16093310
YET1_YEAST	YET1	physical	16093310
SRPB_YEAST	SRP102	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
GSF2_YEAST	GSF2	physical	16093310
FMP42_YEAST	YMR221C	physical	16093310
CUE1_YEAST	CUE1	physical	16093310
PFA4_YEAST	PFA4	physical	16093310
ERP4_YEAST	ERP4	physical	16093310
SEC63_YEAST	SEC63	physical	16093310
YO378_YEAST	AMF1	physical	16093310
GPI2_YEAST	GPI2	physical	16093310
SSU1_YEAST	SSU1	physical	16093310
YOP1_YEAST	YOP1	physical	16093310
TPO3_YEAST	TPO3	physical	16093310
AQY1_YEAST	AQY1	physical	16093310
MSMO_YEAST	ERG25	genetic	23891562
NOP56_YEAST	NOP56	genetic	27708008
SCC1_YEAST	MCD1	genetic	27708008
COPB_YEAST	SEC26	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
ORC6_YEAST	ORC6	genetic	27708008
PRP19_YEAST	PRP19	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
ARPC2_YEAST	ARC35	genetic	27708008
MED4_YEAST	MED4	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.