| UniProt ID | SYWC_YEAST | |
|---|---|---|
| UniProt AC | Q12109 | |
| Protein Name | Tryptophan--tRNA ligase, cytoplasmic | |
| Gene Name | WRS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 432 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | ||
| Protein Sequence | MSNDETVEKVTQQVSELKSTDVKEQVVTPWDVEGGVDEQGRAQNIDYDKLIKQFGTKPVNEETLKRFKQVTGREPHHFLRKGLFFSERDFTKILDLYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQEVFDVPLVIELTDDEKFLFKHKLTINDVKNFARENAKDIIAVGFDPKNTFIFSDLQYMGGAFYETVVRVSRQITGSTAKAVFGFNDSDCIGKFHFASIQIATAFPSSFPNVLGLPDKTPCLIPCAIDQDPYFRVCRDVADKLKYSKPALLHSRFFPALQGSTTKMSASDDTTAIFMTDTPKQIQKKINKYAFSGGQVSADLHRELGGNPDVDVAYQYLSFFKDDDVFLKECYDKYKSGELLSGEMKKLCIETLQEFVKAFQERRAQVDEETLDKFMVPHKLVWGEKERLVAPKPKTKQEKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Phosphorylation | ------MSNDETVEK ------CCCHHHHHH | 53.65 | 27717283 | |
| 6 | Phosphorylation | --MSNDETVEKVTQQ --CCCHHHHHHHHHH | 36.51 | 30377154 | |
| 9 | Ubiquitination | SNDETVEKVTQQVSE CCHHHHHHHHHHHHH | 46.36 | 24961812 | |
| 11 | Phosphorylation | DETVEKVTQQVSELK HHHHHHHHHHHHHHC | 25.09 | 30377154 | |
| 15 | Phosphorylation | EKVTQQVSELKSTDV HHHHHHHHHHCCCCC | 32.64 | 27017623 | |
| 18 | Ubiquitination | TQQVSELKSTDVKEQ HHHHHHHCCCCCCCC | 47.46 | 23749301 | |
| 19 | Phosphorylation | QQVSELKSTDVKEQV HHHHHHCCCCCCCCC | 42.33 | 21440633 | |
| 20 | Phosphorylation | QVSELKSTDVKEQVV HHHHHCCCCCCCCCC | 43.13 | 28889911 | |
| 49 | Acetylation | AQNIDYDKLIKQFGT CCCCCHHHHHHHHCC | 45.97 | 24489116 | |
| 101 | Acetylation | LDLYEQGKPFFLYTG HHHHHCCCCEEEEEC | 38.04 | 24489116 | |
| 153 | Acetylation | EKFLFKHKLTINDVK CCEEEEECCCHHHHH | 48.17 | 24489116 | |
| 160 | Ubiquitination | KLTINDVKNFARENA CCCHHHHHHHHHHCC | 49.57 | 23749301 | |
| 160 | Acetylation | KLTINDVKNFARENA CCCHHHHHHHHHHCC | 49.57 | 24489116 | |
| 168 | Ubiquitination | NFARENAKDIIAVGF HHHHHCCCCEEEEEC | 62.13 | 24961812 | |
| 168 | Succinylation | NFARENAKDIIAVGF HHHHHCCCCEEEEEC | 62.13 | 23954790 | |
| 208 | Phosphorylation | SRQITGSTAKAVFGF HHHCCCCCEEEEECC | 33.26 | 28889911 | |
| 277 | Acetylation | ADKLKYSKPALLHSR HHHHCCCCCHHHHHC | 31.08 | 24489116 | |
| 308 | Phosphorylation | DTTAIFMTDTPKQIQ CCEEEEECCCHHHHH | 26.44 | 24961812 | |
| 310 | Phosphorylation | TAIFMTDTPKQIQKK EEEEECCCHHHHHHH | 24.18 | 24961812 | |
| 312 | Acetylation | IFMTDTPKQIQKKIN EEECCCHHHHHHHHH | 63.22 | 24489116 | |
| 317 | Acetylation | TPKQIQKKINKYAFS CHHHHHHHHHHHHCC | 34.83 | 24489116 | |
| 320 | Acetylation | QIQKKINKYAFSGGQ HHHHHHHHHHCCCCC | 41.24 | 24489116 | |
| 405 | Acetylation | VDEETLDKFMVPHKL CCHHHHHHHCCCCCC | 38.17 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SYWC_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SYWC_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SYWC_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-20, AND MASSSPECTROMETRY. | |
