| UniProt ID | PRP22_YEAST | |
|---|---|---|
| UniProt AC | P24384 | |
| Protein Name | Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22 | |
| Gene Name | PRP22 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1145 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Acts late in the splicing of pre-mRNA. Mediates the release of the spliced mRNA from spliceosomes.. | |
| Protein Sequence | MSDISKLIGAIVGSDDPVIIEFVLNIINKSGNLQEFIRNIQKLDAGISYEDSIKMYNAFLGKQEEEKVRNKVKSSPLSQKINQVLKDDVNLDDPVVTEFVLSILNKSKSITEFQEQLNLMQSGLDNETIFKIYQIASPPVMKEEVSVLPSTKIPAKIEAKIEEEVQKIESLDPSPVLHKVYEGKVRNITTFGCFVQIFGTRMKNCDGLVHISEMSDQRTLDPHDVVRQGQHIFVEVIKIQNNGKISLSMKNIDQHSGEIRKRNTESVEDRGRSNDAHTSRNMKNKIKRRALTSPERWEIRQLIASGAASIDDYPELKDEIPINTSYLTAKRDDGSIVNGNTEKVDSKLEEQQRDETDEIDVELNTDDGPKFLKDQQVKGAKKYEMPKITKVPRGFMNRSAINGSNAIRDHREEKLRKKREIEQQIRKQQSFDDPTKNKKDSRNEIQMLKNQLIVTEWEKNRMNESISYGKRTSLPISAQRQTLPVYAMRSELIQAVRDNQFLVIVGETGSGKTTQITQYLDEEGFSNYGMIGCTQPRRVAAVSVAKRVAEEVGCKVGHDVGYTIRFEDVTGPDTRIKYMTDGMLQREALLDPEMSKYSVIMLDEAHERTVATDVLFALLKKAAIKRPELKVIVTSATLNSAKFSEYFLNCPIINIPGKTFPVEVLYSQTPQMDYIEAALDCVIDIHINEGPGDILVFLTGQEEIDSCCEILYDRVKTLGDSIGELLILPVYSALPSEIQSKIFEPTPKGSRKVVFATNIAETSITIDGIYYVVDPGFAKINIYNARAGIEQLIVSPISQAQANQRKGRAGRTGPGKCYRLYTESAFYNEMLENTVPEIQRQNLSHTILMLKAMGINDLLKFDFMDPPPKNLMLNALTELYHLQSLDDEGKLTNLGKEMSLFPMDPTLSRSLLSSVDNQCSDEIVTIISMLSVQNVFYRPKDRQLEADSKKAKFHHPYGDHLTLLNVYTRWQQANYSEQYCKTNFLHFRHLKRARDVKSQISMIFKKIGLKLISCHSDPDLIRKTFVSGFFMNAAKRDSQVGYKTINGGTEVGIHPSSSLYGKEYEYVMYHSIVLTSREYMSQVTSIEPQWLLEVAPHFYKAGDAESQSRKKAKIIPLHNKFAKDQNSWRLSSIRQSRERALGIKR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 74 | Phosphorylation | KVRNKVKSSPLSQKI HHHHHHHCCHHHHHH | 39.93 | 30377154 | |
| 75 | Phosphorylation | VRNKVKSSPLSQKIN HHHHHHCCHHHHHHH | 24.92 | 23749301 | |
| 246 | Phosphorylation | IQNNGKISLSMKNID EECCCEEEEEEECCC | 20.20 | 29136822 | |
| 248 | Phosphorylation | NNGKISLSMKNIDQH CCCEEEEEEECCCCC | 22.41 | 29136822 | |
| 256 | Phosphorylation | MKNIDQHSGEIRKRN EECCCCCCCCHHHCC | 32.27 | 29136822 | |
| 292 | Phosphorylation | KIKRRALTSPERWEI HHHHHHCCCHHHHHH | 41.05 | 22369663 | |
| 293 | Phosphorylation | IKRRALTSPERWEIR HHHHHCCCHHHHHHH | 26.13 | 22369663 | |
| 305 | Phosphorylation | EIRQLIASGAASIDD HHHHHHHHCCCCCCC | 23.21 | 24961812 | |
| 430 | Phosphorylation | QQIRKQQSFDDPTKN HHHHHHCCCCCCCCC | 28.31 | 30377154 | |
| 473 | Phosphorylation | ISYGKRTSLPISAQR CCCCCCCCCCCCCCC | 35.86 | 23749301 | |
| 482 | Phosphorylation | PISAQRQTLPVYAMR CCCCCCCCCCCHHHH | 34.91 | 22890988 | |
| 486 | Phosphorylation | QRQTLPVYAMRSELI CCCCCCCHHHHHHHH | 7.85 | 22890988 | |
| 490 | Phosphorylation | LPVYAMRSELIQAVR CCCHHHHHHHHHHHH | 24.54 | 22890988 | |
| 562 | Phosphorylation | KVGHDVGYTIRFEDV CCCCCCCCEEEEEEC | 9.99 | 19823750 | |
| 563 | Phosphorylation | VGHDVGYTIRFEDVT CCCCCCCEEEEEECC | 10.35 | 19823750 | |
| 570 | Phosphorylation | TIRFEDVTGPDTRIK EEEEEECCCCCCEEE | 56.15 | 19823750 | |
| 574 | Phosphorylation | EDVTGPDTRIKYMTD EECCCCCCEEEEECC | 37.11 | 19823750 | |
| 577 | Acetylation | TGPDTRIKYMTDGML CCCCCEEEEECCCHH | 26.19 | 25381059 | |
| 578 | Phosphorylation | GPDTRIKYMTDGMLQ CCCCEEEEECCCHHC | 11.68 | 19823750 | |
| 580 | Phosphorylation | DTRIKYMTDGMLQRE CCEEEEECCCHHCHH | 26.72 | 19823750 | |
| 1024 | Phosphorylation | DPDLIRKTFVSGFFM CHHHHHHHHHHCCCC | 21.30 | 28132839 | |
| 1120 | Acetylation | KIIPLHNKFAKDQNS EEECCCHHHCCCCCC | 35.63 | 25381059 | |
| 1132 | Phosphorylation | QNSWRLSSIRQSRER CCCHHHHHHHHHHHH | 26.78 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP22_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP22_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP22_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293, AND MASSSPECTROMETRY. | |
