PBP2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PBP2_YEAST
• UniProt AC: P38151
• Protein Name: PAB1-binding protein 2
• Gene Name: PBP2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 413
• Subcellular Localization: Nucleus .
• Protein Sequence: MSTETTKPSITTTPTTVLVSPNTLKRKKGEDTSEEQLEAEIKRVALKDADSHSDNDHDSPDNVPSDVHLRMLCLVKHASLIVGHKGATISRIKSETSARINISNNIRGVPERIVYVRGTCDDVAKAYGMIVRALLEEHGNEDNGEDIEISINLLIPHHLMGCIIGKRGSRLREIEDLSAAKLFASPNQLLLSNDRILTINGVPDAIHIATFYISQTLLNFQMESPQKNVKRSIYYQPTQFNSVLIDHSQPNTIFHQRNHQYHPSDKLLSYKPNKNLPISSTLLSMATPQYTTASVANATAFQPNFVIPNVTVLDGPVISPAPGNHLLMNFVQQEIFIDEKFVGNVIGKDGKHINSVKESTGCSIIIQDPVEGSSERRLTIRGTFMASQAAIMLISNKIEIDRSNAERKRRSPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TTKPSITTTPTTVLV CCCCCCCCCCCEEEE	29.16	24961812
15	Phosphorylation	PSITTTPTTVLVSPN CCCCCCCCEEEECCC	27.69	21551504
16	Phosphorylation	SITTTPTTVLVSPNT CCCCCCCEEEECCCC	17.04	24961812
20	Phosphorylation	TPTTVLVSPNTLKRK CCCEEEECCCCCCCC	14.31	19823750
23	Phosphorylation	TVLVSPNTLKRKKGE EEEECCCCCCCCCCC	36.72	23607784
33	Phosphorylation	RKKGEDTSEEQLEAE CCCCCCCCHHHHHHH	52.00	27214570
51	Phosphorylation	VALKDADSHSDNDHD HHHHCCCCCCCCCCC	26.98	22369663
53	Phosphorylation	LKDADSHSDNDHDSP HHCCCCCCCCCCCCC	41.90	22369663
59	Phosphorylation	HSDNDHDSPDNVPSD CCCCCCCCCCCCCCH	30.63	22369663
65	Phosphorylation	DSPDNVPSDVHLRML CCCCCCCCHHHHHHH	48.24	22369663
90	Phosphorylation	GHKGATISRIKSETS CCCCCCEEEECCCCC	24.49	28889911
94	Phosphorylation	ATISRIKSETSARIN CCEEEECCCCCCCEE	43.67	28889911
224	Phosphorylation	LLNFQMESPQKNVKR HHHCCCCCCCCCCCC	27.56	23749301
264	Phosphorylation	RNHQYHPSDKLLSYK CCCCCCCCCCCCCCC	33.78	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PBP2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PBP2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PBP2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HMO1_YEAST	HMO1	physical	11805826
EF3A_YEAST	YEF3	physical	11805826
YRA1_YEAST	YRA1	physical	11805826
PBP2_YEAST	PBP2	physical	18719252
GPR1_YEAST	GPR1	genetic	27708008
GNTK_YEAST	YDR248C	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
FEN1_YEAST	RAD27	genetic	27708008
RAD14_YEAST	RAD14	genetic	27708008
PPAL_YEAST	LTP1	genetic	27708008
ASNS1_YEAST	ASN1	genetic	27708008
QKI_HUMAN	QKI	physical	27107014
BEND7_HUMAN	BEND7	physical	27107014
NMNA1_HUMAN	NMNAT1	physical	27107014
TRI39_HUMAN	TRIM39	physical	27107014
SNRPA_HUMAN	SNRPA	physical	27107014
GOGA2_HUMAN	GOLGA2	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53 AND SER-224, AND MASSSPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-51 AND SER-53, AND MASSSPECTROMETRY.
PubMed: 17563356