PCL7_YEAST - dbPTM
PCL7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PCL7_YEAST
UniProt AC P40186
Protein Name PHO85 cyclin-7
Gene Name PCL7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 285
Subcellular Localization Cytoplasm .
Protein Description Cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Together with cyclin PCL6, controls glycogen phosphorylase and glycogen synthase activities in response to nutrient availablility. The PCL7-PHO85 cyclin-CDK holoenzyme has GLC8 kinase activity and phosphorylates and inactivates the phosphatase PP1-2 inhibitor GLC8, causing activation of PP1-2, which then dephosphorylates and activates glycogen phosphorylase. PCL7-PHO85 also phosphorylates MMR1 and YJL084C..
Protein Sequence MELSSPSKKTTTSPINIPGGNRDNLIIGPHSHSFKTDPFSSNNSSLLSKISTNPSLESPFSSKSLLDCSPVQAVKKSLESEAKTHSLDEETNEQTDVKILNIADFPTDELILMISALLNRIITANDETTDVSQQVSDETEDELLTPILAFYGKNVPEIAVVQYLERIQKYCPTTNDIFLSLLVYFDRISKNYGHSSERNGCAKQLFVMDSGNIHRLLITGVTICTKFLSDFFYSNSRYAKVGGISLQELNHLELQFLILCDFKLLVSVEEMQKYANLLYKFWNDQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MELSSPSKKTT
----CCCCCCCCCCC		27.2228889911
5Phosphorylation---MELSSPSKKTTT
---CCCCCCCCCCCC		45.9028152593
7Phosphorylation-MELSSPSKKTTTSP
-CCCCCCCCCCCCCC		49.0530377154
10PhosphorylationLSSPSKKTTTSPINI
CCCCCCCCCCCCCCC		38.7628889911
11PhosphorylationSSPSKKTTTSPINIP
CCCCCCCCCCCCCCC		33.8719795423
12PhosphorylationSPSKKTTTSPINIPG
CCCCCCCCCCCCCCC		37.4225005228
13PhosphorylationPSKKTTTSPINIPGG
CCCCCCCCCCCCCCC		22.9921082442
31PhosphorylationNLIIGPHSHSFKTDP
CEEECCCCCCCCCCC		24.7819795423
33PhosphorylationIIGPHSHSFKTDPFS
EECCCCCCCCCCCCC		31.3019795423
40PhosphorylationSFKTDPFSSNNSSLL
CCCCCCCCCCCHHHH		37.2319795423
41PhosphorylationFKTDPFSSNNSSLLS
CCCCCCCCCCHHHHH		40.1719795423
44PhosphorylationDPFSSNNSSLLSKIS
CCCCCCCHHHHHHHC		26.9819795423
45PhosphorylationPFSSNNSSLLSKIST
CCCCCCHHHHHHHCC		35.1419795423
48PhosphorylationSNNSSLLSKISTNPS
CCCHHHHHHHCCCCC		32.9819795423
52PhosphorylationSLLSKISTNPSLESP
HHHHHHCCCCCCCCC		55.4024961812
55PhosphorylationSKISTNPSLESPFSS
HHHCCCCCCCCCCCC		47.0020377248
58PhosphorylationSTNPSLESPFSSKSL
CCCCCCCCCCCCCCH		36.2224961812
61PhosphorylationPSLESPFSSKSLLDC
CCCCCCCCCCCHHCC		39.9929136822
62PhosphorylationSLESPFSSKSLLDCS
CCCCCCCCCCHHCCC		27.0020377248
64PhosphorylationESPFSSKSLLDCSPV
CCCCCCCCHHCCCHH		35.7920377248
69PhosphorylationSKSLLDCSPVQAVKK
CCCHHCCCHHHHHHH		27.9819823750
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PCL7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PCL7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PCL7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PHO81_YEASTPHO81physical
11069666
PHO85_YEASTPHO85physical
11069666
ALY2_YEASTALY2physical
12098764
GLC8_YEASTGLC8genetic
12407105
MTQ2_YEASTMTQ2physical
16554755
SWI4_YEASTSWI4physical
16554755
TYW3_YEASTTYW3physical
16554755
MMR1_YEASTMMR1physical
11283351
PHO85_YEASTPHO85physical
11283351
SWD3_YEASTSWD3genetic
19269370
SWI4_YEASTSWI4genetic
19269370
UBP3_YEASTUBP3genetic
19269370
ELP2_YEASTELP2genetic
19269370
SSB1_YEASTSSB1physical
19536198
PHO85_YEASTPHO85physical
20489023
PP2C1_YEASTPTC1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
SEI1_YEASTFLD1genetic
27708008
TIM22_YEASTTIM22genetic
27708008
MOB2_YEASTMOB2genetic
27708008
MIF2_YEASTMIF2genetic
27708008
LIP1_YEASTLIP1genetic
27708008
DCP2_YEASTDCP2genetic
27708008
RPC6_YEASTRPC34genetic
27708008
PROF_YEASTPFY1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
TNA1_YEASTTNA1genetic
27708008
OPI1_YEASTOPI1genetic
27708008
NCA3_YEASTNCA3genetic
27708008
ACE2_YEASTACE2genetic
27708008
PFD6_YEASTYKE2genetic
27708008
ATP10_YEASTATP10genetic
27708008
LSM7_YEASTLSM7genetic
27708008
TLG2_YEASTTLG2genetic
27708008
NIP80_YEASTNIP100genetic
27708008
MDL2_YEASTMDL2genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
VPS4_YEASTVPS4genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PCL7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13; SER-45; SER-55;SER-58 AND SER-69, AND MASS SPECTROMETRY.

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