MFA2_YEAST - dbPTM
MFA2_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MFA2_YEAST
UniProt AC P34166
Protein Name Mating hormone A-factor 2
Gene Name MFA2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 38
Subcellular Localization Cell membrane
Lipid-anchor
Cytoplasmic side .
Protein Description The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A..
Protein Sequence MQPITTASTQATQKDKSSEKKDNYIIKGLFWDPACVIA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
35MethylationGLFWDPACVIA----
EEEECCCCEEC----		2.503056940
35FarnesylationGLFWDPACVIA----
EEEECCCCEEC----		2.503056940
35FarnesylationGLFWDPACVIA----
EEEECCCCEEC----		2.503056940
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MFA2_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MFA2_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MFA2_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LSM1_YEASTLSM1physical
17513695
LSM2_YEASTLSM2physical
17513695
LSM3_YEASTLSM3physical
17513695
LSM4_YEASTLSM4physical
17513695
LSM5_YEASTLSM5physical
17513695
LSM6_YEASTLSM6physical
17513695
LSM7_YEASTLSM7physical
17513695
PAT1_YEASTPAT1physical
17513695
GEM1_YEASTGEM1genetic
20093466
NUP60_YEASTNUP60genetic
20093466
GAL10_YEASTGAL10genetic
20093466
AGP2_YEASTAGP2genetic
20093466
CHK1_YEASTCHK1genetic
20093466
PHO89_YEASTPHO89genetic
20093466
GID7_YEASTGID7genetic
20093466
BUD31_YEASTBUD31genetic
20093466
RLA4_YEASTRPP2Bgenetic
20093466
GLRX4_YEASTGRX4genetic
20093466
XRN1_YEASTXRN1genetic
20093466
CUE3_YEASTCUE3genetic
20093466
YBP2_YEASTYBP2genetic
20093466
CGR1_YEASTCGR1genetic
20093466
QCR9_YEASTQCR9genetic
20093466
ELP2_YEASTELP2genetic
20093466
BIOB_YEASTBIO2genetic
20093466
TDA3_YEASTTDA3genetic
20093466
NVJ1_YEASTNVJ1genetic
20093466
POG1_YEASTPOG1genetic
20093466
SDS3_YEASTSDS3genetic
20093466
IST3_YEASTIST3genetic
20093466
SRS2_YEASTSRS2genetic
20093466
YJ24_YEASTKCH1genetic
20093466
PLMT_YEASTOPI3genetic
20093466
FRMSR_YEASTYKL069Wgenetic
20093466
ENV10_YEASTENV10genetic
20093466
SMA2_YEASTSMA2genetic
20093466
SOK2_YEASTSOK2genetic
20093466
SOL1_YEASTSOL1genetic
20093466
TOP1_YEASTTOP1genetic
20093466
MRS2_YEASTMRS2genetic
20093466
MNE1_YEASTMNE1genetic
20093466
AP3D_YEASTAPL5genetic
20093466
SET6_YEASTSET6genetic
20093466
ELP3_YEASTELP3genetic
20093466
RS9A_YEASTRPS9Agenetic
20093466
YP066_YEASTRGL1genetic
20093466
SGF11_YEASTSGF11genetic
20093466
ETFA_YEASTAIM45genetic
20093466
MDM36_YEASTMDM36genetic
20093466
CTF4_YEASTCTF4genetic
20093466
AQY1_YEASTAQY1genetic
20093466
CHK1_YEASTCHK1genetic
22282571
DPOD_YEASTPOL3genetic
27708008
RPN5_YEASTRPN5genetic
27708008
RSP5_YEASTRSP5genetic
27708008
SWC4_YEASTSWC4genetic
27708008
MED6_YEASTMED6genetic
27708008
SC61A_YEASTSEC61genetic
27708008
ORC1_YEASTORC1genetic
27708008
RNA1_YEASTRNA1genetic
27708008
GPI2_YEASTGPI2genetic
27708008
NIP7_YEASTNIP7genetic
27708008
TF2B_YEASTSUA7genetic
27708008
GEM1_YEASTGEM1genetic
27708008
GAL10_YEASTGAL10genetic
27708008
AGP2_YEASTAGP2genetic
27708008
RMD9L_YEASTYBR238Cgenetic
27708008
PHO89_YEASTPHO89genetic
27708008
NHP10_YEASTNHP10genetic
27708008
QRI7_YEASTQRI7genetic
27708008
TMA17_YEASTTMA17genetic
27708008
RAD55_YEASTRAD55genetic
27708008
CGR1_YEASTCGR1genetic
27708008
YBP2_YEASTYBP2genetic
27708008
CUE3_YEASTCUE3genetic
27708008
XRN1_YEASTXRN1genetic
27708008
ELP2_YEASTELP2genetic
27708008
BIOB_YEASTBIO2genetic
27708008
POG1_YEASTPOG1genetic
27708008
IST3_YEASTIST3genetic
27708008
INA22_YEASTINA22genetic
27708008
ASF1_YEASTASF1genetic
27708008
YJ24_YEASTKCH1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
RSSA2_YEASTRPS0Bgenetic
27708008
ENV10_YEASTENV10genetic
27708008
UBX2_YEASTUBX2genetic
27708008
ELP6_YEASTELP6genetic
27708008
INO4_YEASTINO4genetic
27708008
DIA2_YEASTDIA2genetic
27708008
YO105_YEASTYOR105Wgenetic
27708008
SGF11_YEASTSGF11genetic
27708008
ELP3_YEASTELP3genetic
27708008
SET6_YEASTSET6genetic
27708008
MDM36_YEASTMDM36genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MFA2_YEAST

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Related Literatures of Post-Translational Modification
Methylation
ReferencePubMed
"Structure of Saccharomyces cerevisiae mating hormone a-factor.Identification of S-farnesyl cysteine as a structural component.";
Anderegg R.J., Betz R., Carr S.A., Crabb J.W., Duntze W.;
J. Biol. Chem. 263:18236-18240(1988).
Cited for: ISOPRENYLATION AT CYS-35, AND METHYLATION AT CYS-35.
Prenylation
ReferencePubMed
"Structure of Saccharomyces cerevisiae mating hormone a-factor.Identification of S-farnesyl cysteine as a structural component.";
Anderegg R.J., Betz R., Carr S.A., Crabb J.W., Duntze W.;
J. Biol. Chem. 263:18236-18240(1988).
Cited for: ISOPRENYLATION AT CYS-35, AND METHYLATION AT CYS-35.

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