| UniProt ID | NFS1_YEAST | |
|---|---|---|
| UniProt AC | P25374 | |
| Protein Name | Cysteine desulfurase, mitochondrial {ECO:0000303|PubMed:15220327} | |
| Gene Name | NFS1 {ECO:0000312|SGD:S000000522} | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 497 | |
| Subcellular Localization | Mitochondrion . | |
| Protein Description | Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.. | |
| Protein Sequence | MLKSTATRSITRLSQVYNVPAATYRACLVSRRFYSPPAAGVKLDDNFSLETHTDIQAAAKAQASARASASGTTPDAVVASGSTAMSHAYQENTGFGTRPIYLDMQATTPTDPRVLDTMLKFYTGLYGNPHSNTHSYGWETNTAVENARAHVAKMINADPKEIIFTSGATESNNMVLKGVPRFYKKTKKHIITTRTEHKCVLEAARAMMKEGFEVTFLNVDDQGLIDLKELEDAIRPDTCLVSVMAVNNEIGVIQPIKEIGAICRKNKIYFHTDAAQAYGKIHIDVNEMNIDLLSISSHKIYGPKGIGAIYVRRRPRVRLEPLLSGGGQERGLRSGTLAPPLVAGFGEAARLMKKEFDNDQAHIKRLSDKLVKGLLSAEHTTLNGSPDHRYPGCVNVSFAYVEGESLLMALRDIALSSGSACTSASLEPSYVLHALGKDDALAHSSIRFGIGRFSTEEEVDYVVKAVSDRVKFLRELSPLWEMVQEGIDLNSIKWSGH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MLKSTATRSITRLS -CCCCHHHHHHHHHH | 25.66 | 28889911 | |
| 68 | Phosphorylation | AQASARASASGTTPD HHHHHHHHCCCCCCC | 19.88 | 27017623 | |
| 70 | Phosphorylation | ASARASASGTTPDAV HHHHHHCCCCCCCEE | 33.89 | 27017623 | |
| 89 | Phosphorylation | STAMSHAYQENTGFG CCHHHHHHHHCCCCC | 15.78 | 27017623 | |
| 160 | Acetylation | KMINADPKEIIFTSG HHHCCCCCCEEEECC | 63.19 | 24489116 | |
| 165 | Phosphorylation | DPKEIIFTSGATESN CCCCEEEECCCCCCC | 18.82 | 27017623 | |
| 166 | Phosphorylation | PKEIIFTSGATESNN CCCEEEECCCCCCCC | 18.71 | 27017623 | |
| 169 | Phosphorylation | IIFTSGATESNNMVL EEEECCCCCCCCCEE | 43.39 | 27017623 | |
| 171 | Phosphorylation | FTSGATESNNMVLKG EECCCCCCCCCEECC | 29.20 | 27017623 | |
| 299 | N6-(pyridoxal phosphate)lysine | LLSISSHKIYGPKGI EEEEECCCCCCCCCC | 39.30 | - | |
| 299 | Other | LLSISSHKIYGPKGI EEEEECCCCCCCCCC | 39.30 | - | |
| 310 | Phosphorylation | PKGIGAIYVRRRPRV CCCCCEEEEECCCCC | 6.33 | 22369663 | |
| 464 | Acetylation | EEVDYVVKAVSDRVK HHHHHHHHHHHHHHH | 32.78 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NFS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NFS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NFS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
