SAM4_YEAST - dbPTM
SAM4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SAM4_YEAST
UniProt AC Q08985
Protein Name Homocysteine S-methyltransferase 2
Gene Name SAM4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 325
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Homocysteine S-methyltransferase involved in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio. Converts also S-methylmethionine (SMM) to methionine..
Protein Sequence MARLPLKQFLADNPKKVLVLDGGQGTELENRGIKVANPVWSTIPFISESFWSDESSANRKIVKEMFNDFLNAGAEILMTTTYQTSYKSVSENTPIRTLSEYNNLLNRIVDFSRNCIGEDKYLIGCIGPWGAHICREFTGDYGAEPENIDFYQYFKPQLENFNKNDKLDLIGFETIPNIHELKAILSWDESILSRPFYIGLSVHEHGVLRDGTTMEEIAQVIKDLGDKINPNFSFLGINCVSFNQSPDILESLHQALPNMALLAYPNSGEVYDTEKKIWLPNSDKLNSWDTVVKQYISSGARIIGGCCRTSPKDIQEISAAVKKYT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
99PhosphorylationNTPIRTLSEYNNLLN
CCCCCCHHHHHHHHH		37.1028889911
138PhosphorylationAHICREFTGDYGAEP
HHHHHHHHCCCCCCC		25.1328889911
212PhosphorylationHGVLRDGTTMEEIAQ
CCCCCCCCCHHHHHH		27.5327017623
213PhosphorylationGVLRDGTTMEEIAQV
CCCCCCCCHHHHHHH		28.2827017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SAM4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SAM4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SAM4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SIF2_YEASTSIF2genetic
20093466
THRC_YEASTTHR4genetic
20093466
SLX5_YEASTSLX5genetic
20093466
SAC1_YEASTSAC1genetic
20093466
VPS24_YEASTVPS24genetic
20093466
XDJ1_YEASTXDJ1genetic
20093466
UPS2_YEASTUPS2genetic
20093466
ACON2_YEASTACO2genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
SIF2_YEASTSIF2genetic
27708008
HEH2_YEASTHEH2genetic
27708008
ODPA_YEASTPDA1genetic
27708008
MED5_YEASTNUT1genetic
27708008
MED20_YEASTSRB2genetic
27708008
PIR5_YEASTYJL160Cgenetic
27708008
PTK2_YEASTPTK2genetic
27708008
VPS24_YEASTVPS24genetic
27708008
MDM35_YEASTMDM35genetic
27708008
MIC60_YEASTMIC60genetic
27708008
UPS2_YEASTUPS2genetic
27708008
YME1_YEASTYME1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SAM4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-99 AND THR-138, AND MASSSPECTROMETRY.

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