HOT1_YEAST - dbPTM
HOT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HOT1_YEAST
UniProt AC Q03213
Protein Name High-osmolarity-induced transcription protein 1
Gene Name HOT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 719
Subcellular Localization Nucleus .
Protein Description Required for a complete transcriptional response to osmotic stress, through recruitment of HOG1 followed by pol II recruitment to the promoters of GPD1 and other HOG-dependent genes..
Protein Sequence MSGMGIAILCIVRTKIYRITISFDYSTLMSPFFLFLMMPTTLKDGYRMNSQVNEDAIGINLDLSLPTHISPTTGSESASGSNASTLRNDGNALDGGLLRTSAAISAPTGTSQPTETIGEKLSNEERVNSNVSASNSTTAGTGRMLSQSLTNDSPSNEISTDQLKIFQRMDEMSARMIEMEESFNKLSNKIAEQNTMVLNLKQDNYKVMNKLNILLKLVAQPSARPSTNNAQNKLAIELLNSISAVSSAYLQKMQNNGSGRQHTADLCTGDSNTHSGINQHRTTNGTIDVNTNTAQLNNQFSNALNTILPDQQHNRNNVSQNINQSLPNRQLGPVINTQANQNQSQVLIHNTNTHQQVNRSPISFPNASTDKPFKLNPNGIKRRRRNTQSNNNASTNDHASAAQKPISALSPLTNSHNSTTSMNYTNSSIHSGVTSASNSFHDLNSLNNFGTTTALSLPSLALDNASFPPNQNVIPPIINNTQQPLSFSQLINQDSTTSELLPSGKSGVNTNIVNRNRASTLPSYPKPMTVKSNVDDDGYQEDDDDDGDDEGDGRDNEEDSTAEEDEVDDEIETDMKNASINKRRRSLHHKKSNSLNGRRKLHGESATKPNINSDLHYRILKAPTDVKTIWEEYDTGIRGKPSIKHLEAKYGNKWRLNKNKKTFSRRKRLYKFILNGMERGKTAQEMIETLENKRLYKDDEDGEVKKRTIGWLQESLAGI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSGMGIAIL
------CCCCCEEEE		37.1730377154
17PhosphorylationCIVRTKIYRITISFD
EEECCCEEEEEEEEC		9.4928132839
41PhosphorylationLFLMMPTTLKDGYRM
HHHHCCCCCCCCCCC		26.4127017623
46PhosphorylationPTTLKDGYRMNSQVN
CCCCCCCCCCCCCCC		19.4727017623
110PhosphorylationAISAPTGTSQPTETI
EEECCCCCCCCCCCH		27.0222369663
111PhosphorylationISAPTGTSQPTETIG
EECCCCCCCCCCCHH		35.1922369663
114PhosphorylationPTGTSQPTETIGEKL
CCCCCCCCCCHHHHC		37.8222369663
116PhosphorylationGTSQPTETIGEKLSN
CCCCCCCCHHHHCCC		36.4422369663
122PhosphorylationETIGEKLSNEERVNS
CCHHHHCCCHHHHCC		53.9522369663
129PhosphorylationSNEERVNSNVSASNS
CCHHHHCCCCCCCCC		35.4322369663
132PhosphorylationERVNSNVSASNSTTA
HHHCCCCCCCCCCCC		30.1722369663
134PhosphorylationVNSNVSASNSTTAGT
HCCCCCCCCCCCCCC		24.6522369663
136PhosphorylationSNVSASNSTTAGTGR
CCCCCCCCCCCCCCC		25.3322369663
137PhosphorylationNVSASNSTTAGTGRM
CCCCCCCCCCCCCCC		25.5622369663
138PhosphorylationVSASNSTTAGTGRML
CCCCCCCCCCCCCCC		23.9422369663
141PhosphorylationSNSTTAGTGRMLSQS
CCCCCCCCCCCCCCH		21.1022369663
146PhosphorylationAGTGRMLSQSLTNDS
CCCCCCCCCHHCCCC		14.3722369663
148PhosphorylationTGRMLSQSLTNDSPS
CCCCCCCHHCCCCCC		33.5122369663
150PhosphorylationRMLSQSLTNDSPSNE
CCCCCHHCCCCCCCC		42.0828132839
153PhosphorylationSQSLTNDSPSNEIST
CCHHCCCCCCCCCCH		32.0922369663
155PhosphorylationSLTNDSPSNEISTDQ
HHCCCCCCCCCCHHH		51.5522369663
159PhosphorylationDSPSNEISTDQLKIF
CCCCCCCCHHHHHHH		21.5422369663
160PhosphorylationSPSNEISTDQLKIFQ
CCCCCCCHHHHHHHH		33.1622369663
360PhosphorylationTHQQVNRSPISFPNA
CCCCCCCCCCCCCCC		22.7528889911
363PhosphorylationQVNRSPISFPNASTD
CCCCCCCCCCCCCCC		37.7330377154
374AcetylationASTDKPFKLNPNGIK
CCCCCCCCCCCCHHH		56.7524489116
389PhosphorylationRRRRNTQSNNNASTN
HCCCCCCCCCCCCCC		39.2128889911
395PhosphorylationQSNNNASTNDHASAA
CCCCCCCCCCHHHHH		42.1128889911
510PhosphorylationSGKSGVNTNIVNRNR
CCCCCCCCCCCCCCC		24.7424961812
519PhosphorylationIVNRNRASTLPSYPK
CCCCCCCCCCCCCCC		27.5224961812
520PhosphorylationVNRNRASTLPSYPKP
CCCCCCCCCCCCCCC		41.5228152593
523PhosphorylationNRASTLPSYPKPMTV
CCCCCCCCCCCCCEE		58.1221440633
524PhosphorylationRASTLPSYPKPMTVK
CCCCCCCCCCCCEEE		17.2128889911
560PhosphorylationGRDNEEDSTAEEDEV
CCCCCCCCCCCHHHC		32.5628889911
579PhosphorylationETDMKNASINKRRRS
HHHHHHHHHHHHHHH		35.7730377154
608AcetylationLHGESATKPNINSDL
CCCCCCCCCCCCCHH		35.4724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HOT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HOT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HOT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HOG1_YEASTHOG1physical
10409737
CSK2B_YEASTCKB1physical
16554755
CSK2C_YEASTCKB2physical
16554755
CSK22_YEASTCKA2physical
16554755
CSK21_YEASTCKA1physical
20489023
CSK2B_YEASTCKB1physical
20489023
CSK2C_YEASTCKB2physical
20489023
NAP1_YEASTNAP1physical
20489023
ZAP1_YEASTZAP1genetic
20959818
STB5_YEASTSTB5genetic
20959818
AFT1_YEASTAFT1genetic
20959818
MSN2_YEASTMSN2physical
21193057
MSN4_YEASTMSN4physical
21193057
REI1_YEASTREI1genetic
21127252
RSC1_YEASTRSC1genetic
21127252
MET18_YEASTMET18genetic
21127252
GAT2_YEASTGAT2genetic
21127252
RIM11_YEASTRIM11genetic
21127252
KCS1_YEASTKCS1genetic
21127252
HOG1_YEASTHOG1physical
23916462
HOT1_YEASTHOT1physical
23916462
CSK21_YEASTCKA1physical
24817120
CSK22_YEASTCKA2physical
24817120
CSN12_YEASTYJR084Wgenetic
27708008
EIF3J_YEASTHCR1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RPB7_YEASTRPB7genetic
27708008
NEP1_YEASTEMG1genetic
27708008
SEC12_YEASTSEC12genetic
27708008
HRP1_YEASTHRP1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
TBF1_YEASTTBF1genetic
27708008
PEX10_YEASTPEX10genetic
27708008
UBCX_YEASTPEX4genetic
27708008
ELM1_YEASTELM1genetic
27708008
FRMSR_YEASTYKL069Wgenetic
27708008
PEX13_YEASTPEX13genetic
27708008
PALA_YEASTRIM20genetic
27708008
YRA1_YEASTYRA1physical
27480106
GPP1_YEASTGPP1physical
27480106
GPP2_YEASTGPP2physical
27480106
AP1_YEASTYAP1physical
27480106
PABP_YEASTPAB1physical
27480106
NSR1_YEASTNSR1physical
27480106
DEF1_YEASTDEF1physical
27480106
SUB2_YEASTSUB2physical
27480106
PBP1_YEASTPBP1physical
27480106
RPAB2_YEASTRPO26physical
27480106
PBP4_YEASTPBP4physical
27480106
DBP5_YEASTDBP5physical
27480106
SUB1_YEASTSUB1physical
27480106
YRB1_YEASTYRB1physical
27480106
RPA49_YEASTRPA49physical
27480106
NSP1_YEASTNSP1physical
27480106
NOP3_YEASTNPL3physical
27480106
NUP2_YEASTNUP2physical
27480106
SPT5_YEASTSPT5physical
27480106
SUB1_YEASTSUB1genetic
27480106
SPT4_YEASTSPT4genetic
27480106
SPT5_YEASTSPT5genetic
27480106
RPB1_YEASTRPO21physical
27480106
RL36A_YEASTRPL36Agenetic
29158977
DOM34_YEASTDOM34genetic
29158977
SKO1_YEASTSKO1genetic
25904326
HOC1_YEASTHOC1genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HOT1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-111; SER-146; SER-153;SER-155 AND SER-360, AND MASS SPECTROMETRY.

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