| UniProt ID | TPN1_YEAST | |
|---|---|---|
| UniProt AC | P53099 | |
| Protein Name | Vitamin B6 transporter TPN1 | |
| Gene Name | TPN1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 579 | |
| Subcellular Localization |
Membrane Multi-pass membrane protein . |
|
| Protein Description | Thiamine-regulated, high affinity import carrier of pyridoxine, pyridoxal and pyridoxamine.. | |
| Protein Sequence | MNRDNMDTTKRKEDHTKHTTDVIEFYEEGTAASSLNIATEKANSSPSILRRIINRAAWLSKKVDAMGVESTGIQRISPYERGTSKKQFLHVAGLWLSATGGLSSMSSFLLGPLLFGLSFRESVASSLISVTIGCLIAAYCSIMGPQSGCRQMVTARYLFGWWFVKLVALASIIGVMGWSVVNSVVGGEMLAAISNDKVPLWVGIVIVTVCSFLVAIFGIKQVIKVETYLSVPVLTAFLLLYISSSDKYSFVNAYVSKGNLDSSTRKGNWMSFFSLCYSITATWGSITADYYILFPEDTPYIQIFCLTFFGTFLPTCFVGILGLLLASVAMSYKPWSVEYDSHGMGGLLWAGFQRWNGFGKFCVVVLVFSLVSNNIINTYSAAFSIQLSSVFCAKIPRWFWSIVCTIICLVCALIGRNHFSTILGNFLPMIGYWISMYFILLFEENLVFRRFFLHLYTKEFPTVTGEINGPELVGSSKEVEKDAVTNIHLLKRKHKVTKHRYNWDKWEDYEVLTHGYAATFAFIVGVAGVVVGMAQAYWIGPIAAKFGEYGGDVAMWLSMAFSGVVYPPCRYLELRKFGR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Ubiquitination | RDNMDTTKRKEDHTK CCCCCCCCCHHHHCC | 64.66 | 22817900 | |
| 12 | Ubiquitination | NMDTTKRKEDHTKHT CCCCCCCHHHHCCCC | 69.88 | 22817900 | |
| 227 | Phosphorylation | KQVIKVETYLSVPVL CCCCCCCHHHHHHHH | 32.52 | 28889911 | |
| 230 | Phosphorylation | IKVETYLSVPVLTAF CCCCHHHHHHHHHHH | 17.60 | 28889911 | |
| 241 | Phosphorylation | LTAFLLLYISSSDKY HHHHHHHHHCCCCCC | 9.95 | 28889911 | |
| 243 | Phosphorylation | AFLLLYISSSDKYSF HHHHHHHCCCCCCEE | 15.38 | 28889911 | |
| 244 | Phosphorylation | FLLLYISSSDKYSFV HHHHHHCCCCCCEEH | 32.76 | 28889911 | |
| 477 | Ubiquitination | PELVGSSKEVEKDAV CHHCCCCCCCHHHHH | 68.43 | 23749301 | |
| 481 | Ubiquitination | GSSKEVEKDAVTNIH CCCCCCHHHHHHHHH | 57.05 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TPN1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TPN1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TPN1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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