YM87_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YM87_YEAST
• UniProt AC: Q04835
• Protein Name: Uncharacterized membrane protein YMR253C
• Gene Name: YMR253C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 414
• Subcellular Localization: Membrane ; Multi-pass membrane protein . Localizes to cytoplasmic punctate structures.
• Protein Sequence: MNPSVPKVMKRENNTHLLVSKEMNDTSLQLPSTTRSLSPKESNSNEDFNVDGNETTLQRISKDYLKPNIGLVLLTVSYFFNSAMVVSTKVLENDPDDIANDRQIKPLQILLVRMVITYIGTLIYMYINKSTISDVPFGKPEVRKWLVLRGCTGFFGVFGMYYSLMYLTISDAVLITFLAPSLTIFLSWVILRERFTKVEALGSLISLLGVVLIVRPSFLFGTPELTDSSSQIVESSDPKSRLIATLVGLWGVLGMSCVYIIIRYIGKRAHAIMSVSYFSLITAIVSFIGINTIPSMKFQIPHSKKQWILFGNLGVSGFIFQLLLTMGIQRERAGRGSLMTYTQLLYAVFWDVALYKHWPNIWSWIGMIIIISATLWVIRIRAANNETTAKDLTPIIDDEENSIPLTEFDLSDSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MNPSVPKVMKR ----CCCCCCCCCCC	46.15	30377154
21	Ubiquitination	NTHLLVSKEMNDTSL CCEEEEECCCCCCCC	54.20	23749301
27	Phosphorylation	SKEMNDTSLQLPSTT ECCCCCCCCCCCCCC	19.58	27017623
36	Phosphorylation	QLPSTTRSLSPKESN CCCCCCCCCCCCCCC	30.98	23749301
38	Phosphorylation	PSTTRSLSPKESNSN CCCCCCCCCCCCCCC	34.86	20377248
40	Ubiquitination	TTRSLSPKESNSNED CCCCCCCCCCCCCCC	71.10	23749301
42	Phosphorylation	RSLSPKESNSNEDFN CCCCCCCCCCCCCCC	52.24	22369663
44	Phosphorylation	LSPKESNSNEDFNVD CCCCCCCCCCCCCCC	51.37	22369663
117	Phosphorylation	LLVRMVITYIGTLIY HHHHHHHHHHHHHHH	9.55	27017623
121	Phosphorylation	MVITYIGTLIYMYIN HHHHHHHHHHHHHHC	10.63	27017623
124	Phosphorylation	TYIGTLIYMYINKST HHHHHHHHHHHCCCC	6.23	27017623
393	Phosphorylation	ETTAKDLTPIIDDEE CCCCHHHCCCCCCCC	23.68	21440633
402	Phosphorylation	IIDDEENSIPLTEFD CCCCCCCCCCCCCCC	28.94	27017623
411	Phosphorylation	PLTEFDLSDSK---- CCCCCCCCCCC----	41.50	21440633
413	Phosphorylation	TEFDLSDSK------ CCCCCCCCC------	36.57	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YM87_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YM87_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YM87_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GWT1_YEAST	GWT1	genetic	16269340
SHR3_YEAST	SHR3	genetic	16269340
PGA3_YEAST	PGA3	genetic	16269340
ENV10_YEAST	ENV10	genetic	27708008
INO4_YEAST	INO4	genetic	27708008
ALG3_YEAST	ALG3	genetic	27708008
THRC_YEAST	THR4	genetic	27708008
SLX5_YEAST	SLX5	genetic	27708008
SLX8_YEAST	SLX8	genetic	27708008
FYV10_YEAST	FYV10	genetic	27708008
VPS53_YEAST	VPS53	genetic	27708008
EOS1_YEAST	EOS1	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008
AXL1_YEAST	AXL1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-44, AND MASSSPECTROMETRY.
PubMed: 18407956

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42, AND MASSSPECTROMETRY.
PubMed: 17563356