DUR3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DUR3_YEAST
• UniProt AC: P33413
• Protein Name: Urea active transporter
• Gene Name: DUR3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 735
• Subcellular Localization: Membrane; Multi-pass membrane protein.
• Protein Description: Required for active transport of urea..
• Protein Sequence: MGEFKPPLPQGAGYAIVLGLGAVFAGMMVLTTYLLKRYQKEIITAEEFTTAGRSVKTGLVAAAVVSSWIWCSTLLTSSTKEYADGIFGGYAYAAGACFQIIAFAILAIKTKQMAPNAHTYLELVRTRYGKIGHGCYLFYAIATNILVTSMLLTSGSAVFSDLTGMNTIASCFLLPVGVVVYTLFGGIKATFLTDYMHTCVIIIIVLVFAFKVYATSDVLGSPGKVYDLVREAAKRHPVDGNYQGEYMTMTSKSAGILLIINLIGNFGTVFLDNGYWNKAISASPAASLKAYAIGGLAWFAVPSLISLTMGLACLAVETSPNFPTYPDPLTSFQANSGLVLPAAAIAIMGKGGAVASLLMIFMAVTSAMSAELIAVSSVFTYDIYREYIDPRASGKKLIYTSHVACIFFGLAMSGFSVGLYYGGISMGYIYEMMGIIISSAVLPVVLTLCSKDMNLVAAVVSPILGTGLAIMSWLVCTKSLYKELTVDTTFMDYPMLTGNLVALLSPAIFIPILTYVFKPQNFDWEKMKDITRVDETAELVQADPDIQLYDAEANDKEQEEETNSLVSDSEKNDVRVNNEKLIEPNLGVVISNAIFQEDDTQLQNELDEEQRELARGLKIAYFLCVFFALAFLVVWPMPMYGSKYIFSKKFFTGWVVVMIIWLFFSAFAVCIYPLWEGRHGIYTTLRGLYWDLSGQTYKLREWQNSNPQDLHVVTSQISARAHRQSSHFGQVDEII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	TAGRSVKTGLVAAAV CCCHHHHHHHHHHHH	33.32	27017623
66	Phosphorylation	LVAAAVVSSWIWCST HHHHHHHHHHHHHHH	17.23	27017623
67	Phosphorylation	VAAAVVSSWIWCSTL HHHHHHHHHHHHHHH	15.80	27017623
72	Phosphorylation	VSSWIWCSTLLTSST HHHHHHHHHHHCCCC	13.69	27017623
76	Phosphorylation	IWCSTLLTSSTKEYA HHHHHHHCCCCHHHC	24.60	27017623
250	Phosphorylation	QGEYMTMTSKSAGIL CCCEECCCCCCCCEE	24.68	17218313
251	Phosphorylation	GEYMTMTSKSAGILL CCEECCCCCCCCEEE	17.50	17218313
562	Phosphorylation	DKEQEEETNSLVSDS CHHHHHHHHCCCCHH	33.13	24961812
564	Phosphorylation	EQEEETNSLVSDSEK HHHHHHHCCCCHHHH	37.25	28747907
567	Phosphorylation	EETNSLVSDSEKNDV HHHHCCCCHHHHCCC	40.49	24909858
569	Phosphorylation	TNSLVSDSEKNDVRV HHCCCCHHHHCCCCC	42.86	24961812
684	Phosphorylation	GRHGIYTTLRGLYWD CCCCHHHHHHHHEEE	9.48	17218313
714	Phosphorylation	PQDLHVVTSQISARA CCCEEEEHHHHHHHH	17.52	19684113
715	Phosphorylation	QDLHVVTSQISARAH CCEEEEHHHHHHHHH	17.57	28889911
718	Phosphorylation	HVVTSQISARAHRQS EEEHHHHHHHHHHHC	12.22	19684113
725	Phosphorylation	SARAHRQSSHFGQVD HHHHHHHCCCCCCCC	26.24	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DUR3_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DUR3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DUR3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCB3_YEAST	TCB3	physical	18467557
SLM1_YEAST	SLM1	physical	18467557
SFK1_YEAST	SFK1	physical	18467557
OSH7_YEAST	OSH7	physical	18467557
MEP3_YEAST	MEP3	physical	18467557
FAB1_YEAST	FAB1	genetic	20526336
MVB12_YEAST	MVB12	genetic	20526336
PPT2_YEAST	PPT2	genetic	21623372
LTE1_YEAST	LTE1	genetic	27708008
RL19A_YEAST	RPL19B	genetic	27708008
RL19B_YEAST	RPL19B	genetic	27708008
MSP1_YEAST	MSP1	genetic	27708008
PRY1_YEAST	PRY1	genetic	27708008
MNN11_YEAST	MNN11	genetic	27708008
SRL3_YEAST	SRL3	genetic	27708008
SWI6_YEAST	SWI6	genetic	27708008
SEI1_YEAST	FLD1	genetic	27708008
ZRC1_YEAST	ZRC1	genetic	27708008
HPF1_YEAST	HPF1	genetic	27708008
SVL3_YEAST	SVL3	genetic	27708008
NEW1_YEAST	NEW1	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.