PHM7_YEAST - dbPTM
PHM7_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHM7_YEAST
UniProt AC Q12252
Protein Name Phosphate metabolism protein 7
Gene Name PHM7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 991
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Acts as an osmosensitive calcium-permeable cation channel..
Protein Sequence MADSSSTSAFISTLIIYGLTAVVFVWLFLLLRPKNRRVYEPRSLKDIQTIPEEERTEPVPEGYFGWVEYLLSKPHSFLIQHTSVDGYFLLRYIGIVGSLSFVGCLLLLPILLPVNATNGNNLQGFELLSFSNVTNKNRFYAHVFLSWIFFGLFTYVIYKELYYYVVFRHAMQTTPLYDGLLSSRTVIVTELHKSIAQEGEMQMRFPKASNVAFAYDLSDLQELCKERAKNAAKYEAALNKVLNKCVKMTRNKTQKQLDKLYNNGTKPKDDLETYVPHKKRPKHRLGKLPLCLGGKKVNTLSYSSKRIGELNEEIHEKQADWASNDRQPACFIQFETQLEAQRCYQSVEAILGKKNFGKRLIGYSPEDVNWGSMRLSSKERHSRRAVANTIMVLLIIFWAFPVAVVGIISNVNFLTDKVPFLRFINNMPTFLMGVITGLLPTIALVVLMSLVPPFIVMLGKLSGCVTRQETDLYSQAWYYAFAVIQIFLVVTATSSASSTVDSIIDRPRSAMTLLANNLPKASNFYIMYFILKGLTGPTWTILQAVNLLLSKVLGRVLDSTPRQKWNRYNTLATPRMGIVYPGIEILVCIYICYSIIAPILLFFSTVMLTLLYVAYLYNLNYVFGFSFDLKGRNYPRALFQIFVGIYLSEVCLLGLFIMAKTWGPLVLEVFWIVVTALAHIYMKRKFIPLFDAVPLSAIRHARGEPGYSYPTSDLGLQEIKDIADEMKGKYEQDNTHGILTPVTKDDLKKANLIPDNDGSSENGTPSNPFESGSERASLSGSNAESDSIKKLNDTVIKKSSTLSSSTKDNNESTFVPEGEKFRKFHYSDVEALRNKRPYDEDDHSKHGPEGAVPVNADAGVIYSDPAAVMKEPQAFPPDVLETNTWTRRILQFFNPRRSYPFDSVRMRFPLVFNTSIEYDEEYLSSAYTDPCVREKDPIVWCCKDPLGVSKQQIQEARSNGLDVRDDFTRYDEKGKVIFTYNPPDYEPEAKK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
115N-linked_GlycosylationLPILLPVNATNGNNL
HHHHHCCCCCCCCCC		38.82-
132N-linked_GlycosylationFELLSFSNVTNKNRF
EEEEEEECCCCCCCC		42.49-
174PhosphorylationFRHAMQTTPLYDGLL
HHHHCCCCCCCCCHH		8.3919779198
182PhosphorylationPLYDGLLSSRTVIVT
CCCCCHHCCCEEEEE		23.8719779198
183PhosphorylationLYDGLLSSRTVIVTE
CCCCHHCCCEEEEEE		31.7519779198
509PhosphorylationSIIDRPRSAMTLLAN
HHHCCCHHHHHHHHC		25.6925521595
512PhosphorylationDRPRSAMTLLANNLP
CCCHHHHHHHHCCCC		20.5225521595
730PhosphorylationADEMKGKYEQDNTHG
HHHHCCCCCCCCCCC		27.7329136822
740PhosphorylationDNTHGILTPVTKDDL
CCCCCCCCCCCHHHH		17.5029136822
743PhosphorylationHGILTPVTKDDLKKA
CCCCCCCCHHHHHHC		29.9329136822
804PhosphorylationKKSSTLSSSTKDNNE
ECCCCCCCCCCCCCC		45.1828889911
826PhosphorylationEKFRKFHYSDVEALR
CHHEECCHHHHHHHH		15.0824961812
827PhosphorylationKFRKFHYSDVEALRN
HHEECCHHHHHHHHC		26.9824961812
844PhosphorylationPYDEDDHSKHGPEGA
CCCCCCCHHCCCCCC		33.0817287358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHM7_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHM7_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHM7_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UBP3_YEASTUBP3genetic
18931302
SGF73_YEASTSGF73genetic
18931302
PEX22_YEASTPEX22genetic
27708008
NUP60_YEASTNUP60genetic
27708008
SEA4_YEASTSEA4genetic
27708008
GID4_YEASTVID24genetic
27708008
STE50_YEASTSTE50genetic
27708008
PEX19_YEASTPEX19genetic
27708008
RXT3_YEASTRXT3genetic
27708008
ARO1_YEASTARO1genetic
27708008
WDR59_YEASTMTC5genetic
27708008
ODO2_YEASTKGD2genetic
27708008
PEX5_YEASTPEX5genetic
27708008
RMD5_YEASTRMD5genetic
27708008
ERD1_YEASTERD1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
FYV10_YEASTFYV10genetic
27708008
VTC4_YEASTVTC4genetic
27708008
LPLA_YEASTAIM22genetic
27708008
CUL8_YEASTRTT101genetic
27708008
HOC1_YEASTHOC1genetic
27708008
AIM24_YEASTAIM24genetic
27708008
ADY4_YEASTADY4genetic
27708008
DAP1_YEASTDAP1genetic
27708008
CUP9_YEASTCUP9genetic
27708008
ATC3_YEASTDRS2genetic
27708008
SLA1_YEASTSLA1genetic
27708008
SHE1_YEASTSHE1genetic
27708008
PIN4_YEASTPIN4genetic
27708008
RS8A_YEASTRPS8Agenetic
27708008
RS8B_YEASTRPS8Agenetic
27708008
SIF2_YEASTSIF2genetic
27708008
RS6A_YEASTRPS6Bgenetic
27708008
RS6B_YEASTRPS6Bgenetic
27708008
SWC5_YEASTSWC5genetic
27708008
PP2C1_YEASTPTC1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
GPR1_YEASTGPR1genetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
MDHP_YEASTMDH3genetic
27708008
DOS2_YEASTDOS2genetic
27708008
VPS41_YEASTVPS41genetic
27708008
RRP8_YEASTRRP8genetic
27708008
INO2_YEASTINO2genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
ARO80_YEASTARO80genetic
27708008
SNF1_YEASTSNF1genetic
27708008
RL11B_YEASTRPL11Bgenetic
27708008
GSH1_YEASTGSH1genetic
27708008
DS1P1_YEASTLCB3genetic
27708008
F26_YEASTFBP26genetic
27708008
YJY1_YEASTYJR011Cgenetic
27708008
DOHH_YEASTLIA1genetic
27708008
MOG1_YEASTMOG1genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
DPH4_YEASTJJJ3genetic
27708008
SYC1_YEASTSYC1genetic
27708008
TBCA_YEASTRBL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHM7_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-844, AND MASSSPECTROMETRY.

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