USB1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: USB1_YEAST
• UniProt AC: Q12208
• Protein Name: U6 snRNA phosphodiesterase {ECO:0000255|HAMAP-Rule:MF_03040}
• Gene Name: USB1 {ECO:0000255|HAMAP-Rule:MF_03040}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 290
• Subcellular Localization: Nucleus . Mitochondrion .
• Protein Description: Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 3'phosphate. Could be involved in aerobic respiration..
• Protein Sequence: MEFISADYSSSDGSDTESESSNKSEVQIEYTEKTCIQKADSTDLPAIPDSIILKYHIPPNLQKYEHQDMNMSRFWRSFTYFEWRPTPAIHRQLQKIICKYKETFMKQEYTNPYQLVDFDPLFISHLGAPKPLHVSLTRSLLFETEEQRHVFIQEMRNGLRNNEITPFKLQICSYPKLYISERANTLYLGLPVSECPNKAQISPFKTIIAEALQKSGISNYQDLIVSRQNLHVSIAIASNPSKATLKRYQQLNETMGALLLLNNDFAYKLEFLVNSIYCDENRHSIRIPFN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	TCIQKADSTDLPAIP CEEEECCCCCCCCCC		28152593
42	Phosphorylation	CIQKADSTDLPAIPD EEEECCCCCCCCCCC		28889911
205	Acetylation	KAQISPFKTIIAEAL CHHCCHHHHHHHHHH		24489116
275	Phosphorylation	KLEFLVNSIYCDENR HHHHHHHEEEECCCC		27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of USB1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of USB1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of USB1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
QCR1_YEAST	COR1	physical	14690591
PRP19_YEAST	PRP19	physical	14690591
PRP19_YEAST	PRP19	physical	16554755
GCH1_YEAST	FOL2	physical	18719252
PRP19_YEAST	PRP19	physical	18719252
ATG17_YEAST	ATG17	physical	18719252
DAL80_YEAST	DAL80	physical	18719252
CUS2_YEAST	CUS2	physical	18719252
KLHL2_HUMAN	KLHL2	physical	27107014
CACO1_HUMAN	CALCOCO1	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.