HIS5_YEAST - dbPTM
HIS5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HIS5_YEAST
UniProt AC P33734
Protein Name Imidazole glycerol phosphate synthase hisHF
Gene Name HIS7
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 552
Subcellular Localization
Protein Description IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutamine amidotransferase domain provides the ammonia necessary to the cyclase domain to produce IGP and AICAR from PRFAR..
Protein Sequence MPVVHVIDVESGNLQSLTNAIEHLGYEVQLVKSPKDFNISGTSRLILPGVGNYGHFVDNLFNRGFEKPIREYIESGKPIMGICVGLQALFAGSVESPKSTGLNYIDFKLSRFDDSEKPVPEIGWNSCIPSENLFFGLDPYKRYYFVHSFAAILNSEKKKNLENDGWKIAKAKYGSEEFIAAVNKNNIFATQFHPEKSGKAGLNVIENFLKQQSPPIPNYSAEEKELLMNDYSNYGLTRRIIACLDVRTNDQGDLVVTKGDQYDVREKSDGKGVRNLGKPVQLAQKYYQQGADEVTFLNITSFRDCPLKDTPMLEVLKQAAKTVFVPLTVGGGIKDIVDVDGTKIPALEVASLYFRSGADKVSIGTDAVYAAEKYYELGNRGDGTSPIETISKAYGAQAVVISVDPKRVYVNSQADTKNKVFETEYPGPNGEKYCWYQCTIKGGRESRDLGVWELTRACEALGAGEILLNCIDKDGSNSGYDLELIEHVKDAVKIPVIASSGAGVPEHFEEAFLKTRADACLGAGMFHRGEFTVNDVKEYLLEHGLKVRMDEE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43PhosphorylationDFNISGTSRLILPGV
CCCCCCCCCEEECCC		28.7228889911
108AcetylationGLNYIDFKLSRFDDS
CCCHHEEEEECCCCC		41.6324489116
143PhosphorylationGLDPYKRYYFVHSFA
CCCHHHHHHHHHHHH		9.3428889911
144PhosphorylationLDPYKRYYFVHSFAA
CCHHHHHHHHHHHHH		11.8028889911
148PhosphorylationKRYYFVHSFAAILNS
HHHHHHHHHHHHHCC		15.9828889911
155PhosphorylationSFAAILNSEKKKNLE
HHHHHHCCHHHHCCC		47.5528889911
172AcetylationGWKIAKAKYGSEEFI
CCEEEEHHHCCHHHH		49.8122865919
175PhosphorylationIAKAKYGSEEFIAAV
EEEHHHCCHHHHHHH		30.7528889911
199UbiquitinationFHPEKSGKAGLNVIE
CCHHHCCCHHHHHHH		46.5023749301
248PhosphorylationIACLDVRTNDQGDLV
EEEEECCCCCCCCEE		42.8928889911
257PhosphorylationDQGDLVVTKGDQYDV
CCCCEEEECCCCCEE		23.1028889911
258AcetylationQGDLVVTKGDQYDVR
CCCEEEECCCCCEEE		49.2124489116
258UbiquitinationQGDLVVTKGDQYDVR
CCCEEEECCCCCEEE		49.2123749301
262PhosphorylationVVTKGDQYDVREKSD
EEECCCCCEEEECCC		22.5828889911
278AcetylationKGVRNLGKPVQLAQK
CCHHCCCHHHHHHHH		45.2222865919
322PhosphorylationVLKQAAKTVFVPLTV
HHHHHHCCCEEEEEE		17.9124930733
328PhosphorylationKTVFVPLTVGGGIKD
CCCEEEEEECCCCCC		15.8424930733
334AcetylationLTVGGGIKDIVDVDG
EEECCCCCCEEECCC		44.6824489116
342PhosphorylationDIVDVDGTKIPALEV
CEEECCCCCCCHHHH		22.7222369663
351PhosphorylationIPALEVASLYFRSGA
CCHHHHHHHHCCCCC		28.8622369663
353PhosphorylationALEVASLYFRSGADK
HHHHHHHHCCCCCCE		8.4122369663
374PhosphorylationAVYAAEKYYELGNRG
HHHHHHHHHHCCCCC		8.1529688323
375PhosphorylationVYAAEKYYELGNRGD
HHHHHHHHHCCCCCC		18.7529688323
384PhosphorylationLGNRGDGTSPIETIS
CCCCCCCCCCHHHHH		35.7527017623
385PhosphorylationGNRGDGTSPIETISK
CCCCCCCCCHHHHHH		29.4329688323
389PhosphorylationDGTSPIETISKAYGA
CCCCCHHHHHHHHCC		31.1329688323
391PhosphorylationTSPIETISKAYGAQA
CCCHHHHHHHHCCCE		20.7529688323
409PhosphorylationSVDPKRVYVNSQADT
EECCCCEEECCCCCC		9.6528889911
412PhosphorylationPKRVYVNSQADTKNK
CCCEEECCCCCCCCC		19.3928889911
416PhosphorylationYVNSQADTKNKVFET
EECCCCCCCCCEEEE		39.2628889911
419AcetylationSQADTKNKVFETEYP
CCCCCCCCEEEEEEC		50.2724489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HIS5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HIS5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HIS5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HDA2_YEASTHDA2genetic
21288874
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HIS5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND SER-175, AND MASSSPECTROMETRY.

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