dbPTM

PMG2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PMG2_YEAST
UniProt AC	Q12008
Protein Name	Phosphoglycerate mutase 2
Gene Name	GPM2
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	311
Subcellular Localization	Cytoplasm .
Protein Description	Could be non-functional..
Protein Sequence	MTASTPSNVMTLFLLRHGQSELNHENIFCGWIDAKLTEKGKEQARHSAELIEQYCKANNLRLPQIGYTSRLIRTQQTIETMCEEFKLKPQLQVVYDFNKIKLGDEFGSDDKDNMKIPILQTWRLNERHYGSWQGQRKPNVLKEYGKDKYMFIRRDYEGKPPPVDLDREMIQQENEKGSSTGYEFKEPNRQIKYELECSNHDIVLPDSESLREVVYRLNPFLQNVILKLANQYDESSCLIVGHGSSVRSLLKILEGISDDDIKNVDIPNGIPLVVELDKNNGLKFIRKFYLDPESAKINAEKVRNEGFIKNP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74	Phosphorylation	YTSRLIRTQQTIETM CHHHHHHHHHHHHHH	20.31	28889911
99	Acetylation	QVVYDFNKIKLGDEF EEEEECCCEECCCCC	41.01	24489116
232	Phosphorylation	ILKLANQYDESSCLI HHHHHHCCCCCCEEE	22.83	27017623
236	Phosphorylation	ANQYDESSCLIVGHG HHCCCCCCEEEECCH	15.76	27017623
248	Phosphorylation	GHGSSVRSLLKILEG CCHHHHHHHHHHHCC	35.58	27017623

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PMG2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PMG2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PMG2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HUG1_YEAST	HUG1	physical	18467557
YRA2_YEAST	YRA2	physical	18467557
PMG3_YEAST	GPM3	genetic	16941010
MRM2_YEAST	MRM2	genetic	27708008
TAF5_YEAST	TAF5	genetic	27708008
PMM_YEAST	SEC53	genetic	27708008
KTHY_YEAST	CDC8	genetic	27708008
SEC39_YEAST	SEC39	genetic	27708008
TEM1_YEAST	TEM1	genetic	27708008
RPB2_YEAST	RPB2	genetic	27708008
IF6_YEAST	TIF6	genetic	27708008
REI1_YEAST	REI1	genetic	27708008
STE50_YEAST	STE50	genetic	27708008
RIM1_YEAST	RIM1	genetic	27708008
BCS1_YEAST	BCS1	genetic	27708008
HSP31_YEAST	HSP31	genetic	27708008
SLX8_YEAST	SLX8	genetic	27708008
PT122_YEAST	PET122	genetic	27708008
RTF1_YEAST	RTF1	genetic	27708008
RS25A_YEAST	RPS25A	genetic	27708008
SLT2_YEAST	SLT2	genetic	27708008
FLX1_YEAST	FLX1	genetic	27708008
DAL81_YEAST	DAL81	genetic	27708008
IME1_YEAST	IME1	genetic	27708008
PAM17_YEAST	PAM17	genetic	27708008
ERG3_YEAST	ERG3	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
PMS1_YEAST	PMS1	genetic	27708008
ADE_YEAST	AAH1	genetic	27708008
HMI1_YEAST	HMI1	genetic	27708008
MNE1_YEAST	MNE1	genetic	27708008
GGPPS_YEAST	BTS1	genetic	27708008
RU2A_YEAST	LEA1	genetic	27708008
MDL2_YEAST	MDL2	genetic	27708008
YME1_YEAST	YME1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PMG2_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-74, AND MASSSPECTROMETRY.	18407956 [Abstract]