dbPTM

HXT4_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HXT4_YEAST
UniProt AC	P32467
Protein Name	Low-affinity glucose transporter HXT4
Gene Name	HXT4
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	576
Subcellular Localization	Cell membrane Multi-pass membrane protein.
Protein Description	Low-affinity glucose transporter. Can also transport xylose..
Protein Sequence	MSEEAAYQEDTAVQNTPADALSPVESDSNSALSTPSNKAERDDMKDFDENHEESNNYVEIPKKPASAYVTVSICCLMVAFGGFVFGWDTGTISGFVAQTDFIRRFGMKHHDGTYYLSKVRTGLIVSIFNIGCAIGGIILAKLGDMYGRKMGLIVVVVIYIIGIIIQIASINKWYQYFIGRIISGLGVGGIAVLSPMLISEVSPKHIRGTLVSCYQLMITLGIFLGYCTNYGTKTYTNSVQWRVPLGLGFAWALFMIGGMTFVPESPRYLVEVGKIEEAKRSIALSNKVSADDPAVMAEVEVVQATVEAEKLAGNASWGEIFSTKTKVFQRLIMGAMIQSLQQLTGDNYFFYYGTTVFTAVGLEDSFETSIVLGIVNFASTFVGIFLVERYGRRRCLLWGAASMTACMVVFASVGVTRLWPNGKKNGSSKGAGNCMIVFTCFYLFCFATTWAPIPFVVNSETFPLRVKSKCMAIAQACNWIWGFLIGFFTPFISGAIDFYYGYVFMGCLVFSYFYVFFFVPETKGLTLEEVNTLWEEGVLPWKSPSWVPPNKRGTDYNADDLMHDDQPFYKKMFGKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
28	Phosphorylation	LSPVESDSNSALSTP CCCCCCCCCCCCCCC	41.80	27214570
30	Phosphorylation	PVESDSNSALSTPSN CCCCCCCCCCCCCCC	34.24	27214570
45	Ubiquitination	KAERDDMKDFDENHE HHCHHCCCCCCCCCH	63.34	23749301
54	Phosphorylation	FDENHEESNNYVEIP CCCCCHHHCCCEECC	27.65	22369663
57	Phosphorylation	NHEESNNYVEIPKKP CCHHHCCCEECCCCC	12.05	19795423
425	N-linked_Glycosylation	LWPNGKKNGSSKGAG ECCCCCCCCCCCCCC	60.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HXT4_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of HXT4_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HXT4_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HXT5_YEAST	HXT5	genetic	9151960
HXT6_YEAST	HXT6	genetic	9151960
HXT7_YEAST	HXT7	genetic	9151960
YG34_YEAST	YGR122W	genetic	20093466
CHO2_YEAST	CHO2	genetic	20093466
MNN11_YEAST	MNN11	genetic	20093466
YJY1_YEAST	YJR011C	genetic	20093466
DHOM_YEAST	HOM6	genetic	20093466
HXT11_YEAST	HXT11	genetic	9271421
SCC1_YEAST	MCD1	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
STU1_YEAST	STU1	genetic	27708008
NSE4_YEAST	NSE4	genetic	27708008
CDC37_YEAST	CDC37	genetic	27708008
SEC7_YEAST	SEC7	genetic	27708008
PANK_YEAST	CAB1	genetic	27708008
RPN12_YEAST	RPN12	genetic	27708008
SWC4_YEAST	SWC4	genetic	27708008
ARPC5_YEAST	ARC15	genetic	27708008
DPB11_YEAST	DPB11	genetic	27708008
CWC16_YEAST	YJU2	genetic	27708008
CBF3B_YEAST	CEP3	genetic	27708008
VTI1_YEAST	VTI1	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
MED4_YEAST	MED4	genetic	27708008
SYA_YEAST	ALA1	genetic	27708008
HRR25_YEAST	HRR25	genetic	27708008
SYH_YEAST	HTS1	genetic	27708008
PSB5_YEAST	PRE2	genetic	27708008
MED10_YEAST	NUT2	genetic	27708008
SWC3_YEAST	SWC3	genetic	27708008
URA7_YEAST	URA7	genetic	27708008
SEF1_YEAST	SEF1	genetic	27708008
SFT2_YEAST	SFT2	genetic	27708008
TPS1_YEAST	TPS1	genetic	27708008
ODO2_YEAST	KGD2	genetic	27708008
AK_YEAST	HOM3	genetic	27708008
LCL3_YEAST	LCL3	genetic	27708008
YJ24_YEAST	KCH1	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
EOS1_YEAST	EOS1	genetic	27708008
RTC1_YEAST	RTC1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HXT4_YEAST

Related Literatures of Post-Translational Modification

Ubiquitylation
Reference	PubMed
"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery."; Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.; Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-45, AND MASSSPECTROMETRY.	14557538 [Abstract]