YP199_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YP199_YEAST
• UniProt AC: Q08954
• Protein Name: Smr domain-containing protein YPL199C
• Gene Name: YPL199C
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 240
• Subcellular Localization: Cytoplasm .
• Protein Sequence: MKGTGGVVVGTQNPVRDYNHSTDEEYQRLRRLADEAYKKRDQLSHESQTAYQQGDKKLAHELSEKSKAQLKTAEDFNMQAAEYVFVENNADSSSNEIDLHGLYVKEALFILQKRIKFAIDHNEPQLNVIVGKGLHSQNGIAKLKPSIEEFCAKHGIRNHLEKGNSGVLVLELQGVQMQMDGPAVNAPTNQYNAQPHPQYNNNGGQPQGQAQNYNNSGNDNKDSTLTSIFKIFCNCIQSLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKGTGGVVV ------CCCCCCEEE	66.24	23749301
21	Phosphorylation	PVRDYNHSTDEEYQR CCCCCCCCCHHHHHH	33.64	17563356
22	Phosphorylation	VRDYNHSTDEEYQRL CCCCCCCCHHHHHHH	39.62	19795423
38	Ubiquitination	RLADEAYKKRDQLSH HHHHHHHHHHHHCCH	48.67	23749301
44	Phosphorylation	YKKRDQLSHESQTAY HHHHHHCCHHHHHHH	21.41	23749301
47	Phosphorylation	RDQLSHESQTAYQQG HHHCCHHHHHHHHHH	27.66	28889911
49	Phosphorylation	QLSHESQTAYQQGDK HCCHHHHHHHHHHCH	36.29	19823750
51	Phosphorylation	SHESQTAYQQGDKKL CHHHHHHHHHHCHHH	12.54	19823750
56	Ubiquitination	TAYQQGDKKLAHELS HHHHHHCHHHHHHHH	57.41	22817900
57	Ubiquitination	AYQQGDKKLAHELSE HHHHHCHHHHHHHHH	56.50	22817900
63	Phosphorylation	KKLAHELSEKSKAQL HHHHHHHHHHHHHHH	39.74	28889911
65	Acetylation	LAHELSEKSKAQLKT HHHHHHHHHHHHHHC	54.61	24489116
136	Phosphorylation	IVGKGLHSQNGIAKL EEECCCHHCCCHHHC	30.31	23749301
142	Acetylation	HSQNGIAKLKPSIEE HHCCCHHHCCCCHHH	55.94	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YP199_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YP199_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YP199_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
OPLA_YEAST	OXP1	physical	16554755

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21, AND MASSSPECTROMETRY.
PubMed: 17563356