EMW1_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EMW1_YEAST
• UniProt AC: P42842
• Protein Name: Essential for maintenance of the cell wall protein 1
• Gene Name: EMW1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 904
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Required for the maintenance of the cell wall integrity..
• Protein Sequence: METLLHAKLLLSAEVESLKSGSFDQTYVKKAEHIISGESYQLVQQFVDKFKGKISISGEISTSSVIAALNDFLNVEVFKMGQENEMLFLAIALLQTFIQNNYTGPAARLKAISGLFGKTGIEIGAVNTALSRSLAIMGQPAYEFMDDPLYLVLSLLLLERITGQKSLFDVTPDQEIPLPIISAESTPGLLAVAYWWWARALLTQLSLIPEPSGFQASVASAIYQSADLAYAITKELPESIHEDFKRELCAMYYLENVKCSLAINTEHLCLPSLTRAKKITNFEFVMTGARATRTKYQQKAHAGLIILAKSFTFQNFALRTTSATPETFALESDLLLEKPHFESIADEPLDEQIYSKRQKVDLNEGYEEDKLLPLALRQENIPKLLLDLNPNDQPTLSDYDNIQLLLRLYTIKNTTPAKDPLVEEELTALLSRILYQNGDKNWSIFARSLWERSIIETTKAKTIERGLLQMQSLVEELDLKIKSKLVPSSSEINVASRLSYIHQLPFIPRWQLDATLAEKYMSLGILKSAVEIYERLGMACETALCYAAVGDEKKAEEILLQRINENDSDARAYSILGDIKQDPSLWEKSWEIGKYVNAKNSLAKYYFNPPPKSGAQPNYSATLKHLNDSLRQYPLSFETWYFYGCVGLQCGKMQIAAEAFTRCVSLDPYHALSWSNLSAAYTKMDKLKEAYSCLKRAISCDAQKNWKIWENYMLVAVKLNEWEDVLTACKQLVSIRRDKSGEGSIDLPIIEKLVELLVTSEYPEEPQQLSYFQKSCTEFICNTLPQVITTSARCWRLVARVELWRKRPWAALECHEKAYRAISHNPDLEVEEKVWNDTVDACEDLVAAYESLGEMEGKYGPGSLVCKDWKYKCRSTIKALMSKGKGRWDDSPGWDRLVEARSQI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LHAKLLLSAEVESLK HHHHHHHHHHHHHHH	23.50	19779198
17	Phosphorylation	LLSAEVESLKSGSFD HHHHHHHHHHCCCCC	46.39	19779198
22	Phosphorylation	VESLKSGSFDQTYVK HHHHHCCCCCHHHHH	32.51	19779198
245	Acetylation	ESIHEDFKRELCAMY HHHCHHHHHHHHHHH	58.23	24489116
309	Ubiquitination	AGLIILAKSFTFQNF CCEEEEEEECEECCC	42.53	17644757
482	Ubiquitination	EELDLKIKSKLVPSS HHHCHHHHHHCCCCC	39.69	17644757
484	Ubiquitination	LDLKIKSKLVPSSSE HCHHHHHHCCCCCCC	48.80	17644757
484	Acetylation	LDLKIKSKLVPSSSE HCHHHHHHCCCCCCC	48.80	24489116
604	Ubiquitination	NAKNSLAKYYFNPPP CCCCCCHHHHCCCCC	45.86	23749301
624	Acetylation	PNYSATLKHLNDSLR CCHHHHHHHHHHHHH	41.51	24489116
739	Ubiquitination	LVSIRRDKSGEGSID HHHHCCCCCCCCCCC	59.56	17644757
752	Ubiquitination	IDLPIIEKLVELLVT CCHHHHHHHHHHHHC	47.64	17644757
875	Phosphorylation	DWKYKCRSTIKALMS CCCHHHHHHHHHHHH	43.91	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EMW1_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EMW1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EMW1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYG_YEAST	GRS1	physical	14690591
GRP78_YEAST	KAR2	physical	14690591
TBA3_YEAST	TUB3	physical	14690591
EMW1_YEAST	EMW1	physical	14759368
ATPB_YEAST	ATP2	physical	11805826
GFA1_YEAST	GFA1	physical	11805826
IMB4_YEAST	KAP123	physical	11805826
LYS12_YEAST	LYS12	physical	11805826
PRS6A_YEAST	RPT5	physical	11805826
VATA_YEAST	VMA1	physical	11805826
HSP26_YEAST	HSP26	physical	16554755
HSP7F_YEAST	SSE1	physical	19536198
SSB1_YEAST	SSB1	physical	19536198
THRC_YEAST	THR4	genetic	20093466
EAF1_YEAST	EAF1	genetic	20093466
RV167_YEAST	RVS167	genetic	20093466
RL22A_YEAST	RPL22A	genetic	20093466
BMT6_YEAST	BMT6	genetic	20093466
PFD6_YEAST	YKE2	genetic	20093466
VRP1_YEAST	VRP1	genetic	20093466
RSC2_YEAST	RSC2	genetic	20093466
ROM2_YEAST	ROM2	genetic	20093466
INO4_YEAST	INO4	genetic	20093466
SERC_YEAST	SER1	genetic	20093466
GGPPS_YEAST	BTS1	genetic	20093466
GFA1_YEAST	GFA1	genetic	21273246
PMP1_YEAST	PMP1	physical	26404137

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.