| UniProt ID | FCF2_YEAST | |
|---|---|---|
| UniProt AC | Q12035 | |
| Protein Name | rRNA-processing protein FCF2 | |
| Gene Name | FCF2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 217 | |
| Subcellular Localization | Nucleus, nucleolus . | |
| Protein Description | Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly. Required for the early cleavage steps of 35S rRNA at the A(0), A(1), and A(2) sites.. | |
| Protein Sequence | MDQSVEDLFGALRDASASLEVKNSAKEQVSLQQEDVLQIGNNDDEVEIESKFQEIETNLKKLPKLETGFDALANKKKKKNVLPSVETEDKRKPNKSDKNDNDWFTLPKPDDNMRREVQRDLLLIKHRAALDPKRHYKKQRWEVPERFAIGTIIEDKSEFYSSRMNRKERKSTILETLMGDEASNKYFKRKYNEIQEKSTSGRKAHYKKMKEMRKKRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MDQSVEDL -------CCCCHHHH | 10.77 | 22814378 | |
| 4 | Phosphorylation | ----MDQSVEDLFGA ----CCCCHHHHHHH | 24.18 | 28152593 | |
| 16 | Phosphorylation | FGALRDASASLEVKN HHHHHHHHHCCEECC | 23.76 | 27214570 | |
| 18 | Phosphorylation | ALRDASASLEVKNSA HHHHHHHCCEECCCH | 23.67 | 30377154 | |
| 24 | Phosphorylation | ASLEVKNSAKEQVSL HCCEECCCHHHCCCC | 34.69 | 27017623 | |
| 87 | Phosphorylation | NVLPSVETEDKRKPN CCCCCCCCCCCCCCC | 47.53 | 19684113 | |
| 125 | Acetylation | QRDLLLIKHRAALDP HHHHHHHHHHHHCCC | 27.32 | 24489116 | |
| 156 | Ubiquitination | IGTIIEDKSEFYSSR CCEEECCHHHHHHHH | 38.81 | 23749301 | |
| 171 | Phosphorylation | MNRKERKSTILETLM CCHHHHHHHHHHHHH | 27.23 | 19779198 | |
| 172 | Phosphorylation | NRKERKSTILETLMG CHHHHHHHHHHHHHC | 32.39 | 27017623 | |
| 185 | Ubiquitination | MGDEASNKYFKRKYN HCCHHHHHHHHHHHH | 49.95 | 22817900 | |
| 188 | Ubiquitination | EASNKYFKRKYNEIQ HHHHHHHHHHHHHHH | 44.91 | 22817900 | |
| 190 | Ubiquitination | SNKYFKRKYNEIQEK HHHHHHHHHHHHHHH | 53.68 | 22817900 | |
| 190 | Acetylation | SNKYFKRKYNEIQEK HHHHHHHHHHHHHHH | 53.68 | 25381059 | |
| 197 | Ubiquitination | KYNEIQEKSTSGRKA HHHHHHHHCCCCHHH | 42.53 | 23749301 | |
| 197 | Acetylation | KYNEIQEKSTSGRKA HHHHHHHHCCCCHHH | 42.53 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of FCF2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of FCF2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of FCF2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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