dbPTM

NNRE_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NNRE_YEAST
UniProt AC	P40165
Protein Name	NAD(P)H-hydrate epimerase {ECO:0000255\|HAMAP-Rule:MF_03159}
Gene Name	YNL200C
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	246
Subcellular Localization	Cytoplasm. Mitochondrion.
Protein Description	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX..
Protein Sequence	MSTLKVVSSKLAAEIDKELMGPQIGFTLQQLMELAGFSVAQAVCRQFPLRGKTETEKGKHVFVIAGPGNNGGDGLVCARHLKLFGYNPVVFYPKRSERTEFYKQLVHQLNFFKVPVLSQDEGNWLEYLKPEKTLCIVDAIFGFSFKPPMREPFKGIVEELCKVQNIIPIVSVDVPTGWDVDKGPISQPSINPAVLVSLTVPKPCSSHIRENQTTHYVGGRFIPRDFANKFGFEPFGYESTDQILKL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	TLKVVSSKLAAEIDK CHHHHHHHHHHHHHH	34.34	24489116
82	Acetylation	LVCARHLKLFGYNPV EEEEHHHHHCCCCCE	35.33	24489116
94	Acetylation	NPVVFYPKRSERTEF CCEEECCCCHHHHHH	58.12	24489116
103	Acetylation	SERTEFYKQLVHQLN HHHHHHHHHHHHHCC	42.34	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of NNRE_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of NNRE_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NNRE_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MOB2_YEAST	MOB2	genetic	27708008
NU192_YEAST	NUP192	genetic	27708008
KTHY_YEAST	CDC8	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
ROT1_YEAST	ROT1	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
TYSY_YEAST	CDC21	genetic	27708008
UFE1_YEAST	UFE1	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NNRE_YEAST

Related Literatures of Post-Translational Modification