ASSY_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASSY_YEAST
• UniProt AC: P22768
• Protein Name: Argininosuccinate synthase
• Gene Name: ARG1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 420
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the eighth step in arginine biosynthesis. Also has a catabolic function as the first enzyme of citrulline utilization as nitrogen source via arginine and the reactions involved in the arginase pathway..
• Protein Sequence: MSKGKVCLAYSGGLDTSVILAWLLDQGYEVVAFMANVGQEEDFDAAKEKALKIGACKFVCVDCREDFVKDILFPAVQVNAVYEDVYLLGTSLARPVIAKAQIDVAKQEGCFAVSHGCTGKGNDQIRFELSFYALKPDVKCITPWRMPEFFERFAGRKDLLDYAAQKGIPVAQTKAKPWSTDENQAHISYEAGILEDPDTTPPKDMWKLIVDPMDAPDQPQDLTIDFERGLPVKLTYTDNKTSKEVSVTKPLDVFLAASNLARANGVGRIDIVEDRYINLKSRGCYEQAPLTVLRKAHVDLEGLTLDKEVRQLRDSFVTPNYSRLIYNGSYFTPECEYIRSMIQPSQNSVNGTVRVRLYKGNVIILGRSTKTEKLYDPTESSMDELTGFLPTDTTGFIAIQAIRIKKYGESKKTKGEELTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Acetylation	ALKIGACKFVCVDCR HHHCCCCEEEEECCC	40.05	25381059
106	Acetylation	KAQIDVAKQEGCFAV HHHHHHHHHCCCEEE	49.05	24489116
135	Ubiquitination	ELSFYALKPDVKCIT EEEEEEECCCCEEEC	30.88	24961812
157	Succinylation	FERFAGRKDLLDYAA HHHHCCCHHHHHHHH	52.38	23954790
162	Phosphorylation	GRKDLLDYAAQKGIP CCHHHHHHHHHCCCC	12.10	28889911
173	Phosphorylation	KGIPVAQTKAKPWST CCCCCEECCCCCCCC	24.19	22369663
233	Acetylation	FERGLPVKLTYTDNK ECCCCEEEEEEECCC	32.92	24489116
243	Acetylation	YTDNKTSKEVSVTKP EECCCCCCEEEECCC	68.33	24489116
246	Phosphorylation	NKTSKEVSVTKPLDV CCCCCEEEECCCHHH	25.76	22369663
248	Phosphorylation	TSKEVSVTKPLDVFL CCCEEEECCCHHHHH	21.31	22369663
249	Acetylation	SKEVSVTKPLDVFLA CCEEEECCCHHHHHH	41.23	24489116
258	Phosphorylation	LDVFLAASNLARANG HHHHHHHHHHHHHCC	27.11	22369663
280	Acetylation	EDRYINLKSRGCYEQ ECCEEECCCCCCCCC	33.35	25381059
307	Ubiquitination	LEGLTLDKEVRQLRD CCCCCCCHHHHHHHH	62.31	24961812
315	Phosphorylation	EVRQLRDSFVTPNYS HHHHHHHCCCCCCCC	18.38	22369663
318	Phosphorylation	QLRDSFVTPNYSRLI HHHHCCCCCCCCEEE	12.10	22369663
321	Phosphorylation	DSFVTPNYSRLIYNG HCCCCCCCCEEEECC	9.07	22369663
322	Phosphorylation	SFVTPNYSRLIYNGS CCCCCCCCEEEECCC	27.53	22369663
375	Phosphorylation	STKTEKLYDPTESSM CCCCCCCCCCCCCCH	30.83	22369663
378	Phosphorylation	TEKLYDPTESSMDEL CCCCCCCCCCCHHHH	45.67	22369663
380	Phosphorylation	KLYDPTESSMDELTG CCCCCCCCCHHHHCC	33.18	22369663
381	Phosphorylation	LYDPTESSMDELTGF CCCCCCCCHHHHCCC	24.83	22369663
386	Phosphorylation	ESSMDELTGFLPTDT CCCHHHHCCCCCCCC	24.68	22369663
391	Phosphorylation	ELTGFLPTDTTGFIA HHCCCCCCCCCCEEE	48.39	22369663
393	Phosphorylation	TGFLPTDTTGFIAIQ CCCCCCCCCCEEEEE	31.15	22369663
394	Phosphorylation	GFLPTDTTGFIAIQA CCCCCCCCCEEEEEE	32.67	22369663
413	Phosphorylation	KYGESKKTKGEELTL ECCCCCCCCCCCCCC	48.28	22369663
419	Phosphorylation	KTKGEELTL------ CCCCCCCCC------	33.43	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASSY_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASSY_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASSY_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CAN1_YEAST	CAN1	genetic	16941010
GAP1_YEAST	GAP1	genetic	16941010

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.