VTH2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VTH2_YEAST
• UniProt AC: P40890
• Protein Name: VPS10 homolog 2
• Gene Name: VTH2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1549
• Subcellular Localization: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.
• Protein Description: Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A..
• Protein Sequence: MALFRALYIIWVFLLIPLSNAEEFTPKVTRTLSRYVFDIVNFDDSNTLIRAEEDSVEISFDAGENWKTIDEIEEPIESFVVDPFRGHDRAFAFVKTAPKFYVTDDQGKSWRPLTIPISEKASNYFCDVTTHPIKKKHLIIRCDLLTIKNSGLMYVGREIYTTNDGVSFSQVKPSFGKIDGHISTARCDFIKSSEDSDLGGNDASILCLFRNTEYIESTGSTIDKSELILSADGGETFKELVQFKDKVVSRYEILKHHVIVLTQDDMYNEMSSTNIWISNDVSTFQVARTPTKIRHVNMGQIHEDSIGRIVLPVSRERDDEDSNQPGAAEVLISDSEGLKFLPINWIPNNQFGYINVAYPGFLKGTFFGSFHPFIEYSDRKRKYSRQKVREETKVSVDNGLTWTNLKVVDRENVDLFGCDVTKPERCSLQTHFYDLRNLNPSAGIMMISGIVGDGSAYNWKEEKTFISRDSGLTWRLVHNSTGLYTTGDLGNIIMYIPYRSNENGDVPSKFYYSLDQGKTWGEYDLIMPIYPYRLVSTISDGSGSKFILTGTSITEDPIFITYSIDFSAVFDYKSCEEGDFEDWNLADGKCVNGAKYKYRRRKQDAQCLVKKAFKDLSLDETPCNSCTGSDYECSFEFVRDAKGDCIPDYNLIALSDICDKSKGKSVLVKPLQLIKGDKCKTPMKIESVDIPCDEIPKEGSSDKEIVTTENKFDFEIKFYQYFDTVADESLVMLNSIGDAYISHDGGQTIKRFDTDGEKIVEIVFNPYFNSSAYLFGSKGNIFLTHDRGYSFMIAKLPEARQLGMPLDFSAKAQDTFIYYGGKNCESILSPECHAVAYLTKDGGETFTEMLDNAIHCEFAGTLFKYPSNDDMVMCQVKEKFSQTRSLVSSTDFFQDDRKTVFENIIGYLSTGGYIIVAVPHEDNELRAYVTNDGAEFTEAKFPYDEDIGKQDAFTILGSEEGSIFLHLATNLESGHDFGNLLKSNSNGTSFVTLEHAVNRNTFGYVDFEKVQGLEGIIITNIVSNSEKVGENKEDEQLKTKITFNDGSDWNFLKPPKKDSEGKKFPCDSVSLDKCSLHLHGYTERKDIRDTYSSGSALGMMFGVGNVGDRLLPYEECSTFLTTDGGETWTEVKKGPHQWEYGDHGGVLVLVPENAETDSISYSTDFGKTWKDYKFCGDKVLVKDIITVPRDSALRFLLFGEAKNMGSGSFRTYTIDFRNIFERQCEFDITGRKRADFKYSPLGSRTGCLFGHKTEFLRKTDEKCFIGNIPLSEFSRNVKNCPCTRQDFECDYNFYKASDGTCKLVKGLSSANGADICKKEPDLIEYYDSSGYRKIPLSTCKGGLKLDAHLAPHPCPGKEKAFREKYSINTGAYALVFVTILLVIFFVAWFVYDRGIRRNGGFSRFEEIRLGDDGLIENNRTDRVVNIIVRLGLCISLITKSAFQRAKAGTAQLSSKFRARFGNKKGATYSSLLHDQLSDEPDGFHEDSNDLSSFRGQGSNSEIEQEDVDTSQQEHTSRTDLLGASNIPDALPARSASHESDLAAARSEDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
191	Ubiquitination	TARCDFIKSSEDSDL ECCCCEECCCCCCCC	48.17	17644757
433	Phosphorylation	CSLQTHFYDLRNLNP CCCEEEEECCCCCCC	13.38	28889911
441	Phosphorylation	DLRNLNPSAGIMMIS CCCCCCCCCCEEEEE	37.75	27017623
455	Phosphorylation	SGIVGDGSAYNWKEE EEEECCCCCCCCCCC	32.11	27017623
457	Phosphorylation	IVGDGSAYNWKEEKT EECCCCCCCCCCCEE	24.21	27017623
479	N-linked_Glycosylation	LTWRLVHNSTGLYTT CCEEEEECCCCCEEC	33.51	-
500	Phosphorylation	IMYIPYRSNENGDVP EEEEECCCCCCCCCC	42.52	19684113
769	N-linked_Glycosylation	IVFNPYFNSSAYLFG EEECCCCCCCEEEEC	29.25	-
811	Ubiquitination	MPLDFSAKAQDTFIY CCCCCCHHHCCEEEE	45.44	17644757
822	Ubiquitination	TFIYYGGKNCESILS EEEEECCCCHHHHCC	54.80	17644757
840	Ubiquitination	HAVAYLTKDGGETFT CEEEEEECCCCCCHH	52.35	17644757
986	N-linked_Glycosylation	NLLKSNSNGTSFVTL HHCCCCCCCCCEEEE	63.11	-
1178	Ubiquitination	DYKFCGDKVLVKDII CCCCCCCEEEEEEEE	23.81	17644757
1182	Ubiquitination	CGDKVLVKDIITVPR CCCEEEEEEEEEECC	38.76	17644757
1262	Ubiquitination	FLRKTDEKCFIGNIP HHHCCCCCCEECCCC	36.94	23793018
1309	Phosphorylation	KLVKGLSSANGADIC EEEHHHHHCCCCHHC	30.69	27017623
1325	Phosphorylation	KEPDLIEYYDSSGYR CCCCCEEEECCCCCC	12.94	28889911
1326	Phosphorylation	EPDLIEYYDSSGYRK CCCCEEEECCCCCCE	9.14	28889911
1331	Phosphorylation	EYYDSSGYRKIPLST EEECCCCCCEEEHHH	15.64	28889911
1453	Phosphorylation	KAGTAQLSSKFRARF HCCCHHCCHHHHHHH	21.28	28889911
1498	Phosphorylation	SSFRGQGSNSEIEQE HHHCCCCCCCCCCHH	29.33	28889911
1500	Phosphorylation	FRGQGSNSEIEQEDV HCCCCCCCCCCHHHC	41.47	28889911
1509	Phosphorylation	IEQEDVDTSQQEHTS CCHHHCCCCHHHHCC	28.43	29136822
1534	Phosphorylation	PDALPARSASHESDL CCCCCCCCCCCHHHH	35.91	22369663
1536	Phosphorylation	ALPARSASHESDLAA CCCCCCCCCHHHHHH	29.09	22369663
1539	Phosphorylation	ARSASHESDLAAARS CCCCCCHHHHHHHHH	32.28	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VTH2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VTH2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VTH2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MKAR_YEAST	IFA38	physical	16093310
ELO2_YEAST	ELO2	physical	16093310
HXT10_YEAST	HXT10	physical	16093310
YET1_YEAST	YET1	physical	16093310
ELO3_YEAST	ELO3	physical	16093310
GSF2_YEAST	GSF2	physical	16093310
OST3_YEAST	OST3	physical	16093310

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.