GLO2_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GLO2_YEAST
• UniProt AC: Q05584
• Protein Name: Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
• Gene Name: GLO2
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 274
• Subcellular Localization: Cytoplasm.
• Protein Description: Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid..
• Protein Sequence: MQVKSIKMRWESGGVNYCYLLSDSKNKKSWLIDPAEPPEVLPELTEDEKISVEAIVNTHHHYDHADGNADILKYLKEKNPTSKVEVIGGSKDCPKVTIIPENLKKLHLGDLEITCIRTPCHTRDSICYYVKDPTTDERCIFTGDTLFTAGCGRFFEGTGEEMDIALNNSILETVGRQNWSKTRVYPGHEYTSDNVKFVRKIYPQVGENKALDELEQFCSKHEVTAGRFTLKDEVEFNPFMRLEDPKVQKAAGDTNNSWDRAQIMDKLRAMKNRM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MQVKSIKMRWES ---CCCEEEEEEEEC	28.69	21126336
12	Phosphorylation	SIKMRWESGGVNYCY EEEEEEECCCCCEEE	33.61	23749301
17	Phosphorylation	WESGGVNYCYLLSDS EECCCCCEEEEEECC	4.69	23749301
22	Phosphorylation	VNYCYLLSDSKNKKS CCEEEEEECCCCCCE	36.92	23749301
24	Phosphorylation	YCYLLSDSKNKKSWL EEEEEECCCCCCEEE	34.45	23749301
104	Acetylation	TIIPENLKKLHLGDL EECCCCCCCCCCCCC	65.94	24489116
131	Acetylation	DSICYYVKDPTTDER CCEEEEEECCCCCCC	41.70	24489116
131	Ubiquitination	DSICYYVKDPTTDER CCEEEEEECCCCCCC	41.70	23749301
148	Phosphorylation	FTGDTLFTAGCGRFF EECCEEEECCCCCCC	25.83	19779198
158	Phosphorylation	CGRFFEGTGEEMDIA CCCCCCCCCCHHHHH	33.93	19779198
169	Phosphorylation	MDIALNNSILETVGR HHHHHHCCHHHHHCC	27.72	27017623
173	Phosphorylation	LNNSILETVGRQNWS HHCCHHHHHCCCCCC	25.47	19779198
196	Acetylation	EYTSDNVKFVRKIYP CCCCCCHHHHHHHHH	44.38	24489116
220	Acetylation	ELEQFCSKHEVTAGR HHHHHHHHCCCCCCC	44.99	24489116
249	Ubiquitination	LEDPKVQKAAGDTNN CCCHHHHHHCCCCCC	43.10	23749301
254	Phosphorylation	VQKAAGDTNNSWDRA HHHHCCCCCCCCHHH	35.07	22369663
257	Phosphorylation	AAGDTNNSWDRAQIM HCCCCCCCCHHHHHH	32.21	22369663
266	Acetylation	DRAQIMDKLRAMKNR HHHHHHHHHHHHHHC	23.61	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GLO2_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GLO2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GLO2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRX1_YEAST	TRX1	physical	16554755
HSV2_YEAST	HSV2	physical	18467557
THDH_YEAST	ILV1	genetic	21623372

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-257, AND MASSSPECTROMETRY.
PubMed: 18407956