TRNL_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRNL_YEAST
• UniProt AC: P09880
• Protein Name: tRNA ligase
• Gene Name: TRL1
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 827
• Protein Description: One of the two proteins required for the splicing of precursor tRNA molecules containing introns. The ligation activity requires three enzymatic activities: phosphorylation of the 5' terminus of the 3' half-tRNA in the presence of ATP, opening of the 2'3'-cyclic phosphodiester bond of the 5' half-tRNA leaving a 2'-phosphomonoester and ligation of the two tRNA halves in an ATP-dependent reaction..
• Protein Sequence: MPSPYDGKRTVTQLVNELEKAEKLSGRGRAYRRVCDLSHSNKKVISWKFNEWDYGKNTITLPCNARGLFISDDTTNPVIVARGYDKFFNVGEVNFTKWNWIEENCTGPYDVTIKANGCIIFISGLEDGTLVVCSKHSTGPRADVDRNHAEAGEKQLLRQLAAMNINRSDFARMLYTHNVTAVAEYCDDSFEEHILEYPLEKAGLYLHGVNVNKAEFETWDMKDVSQMASKYGFRCVQCITSNTLEDLKKFLDNCSATGSFEGQEIEGFVIRCHLKSTEKPFFFKYKFEEPYLMYRQWREVTKDYISNKSRVFKFRKHKFITNKYLDFAIPILESSPKICENYLKGFGVIELRNKFLQSYGMSGLEILNHEKVAELELKNAIDYDKVDERTKFLIFPISVIGCGKTTTSQTLVNLFPDSWGHIQNDDITGKDKSQLMKKSLELLSKKEIKCVIVDRNNHQFRERKQLFEWLNELKEDYLVYDTNIKVIGVSFAPYDKLSEIRDITLQRVIKRGNNHQSIKWDELGEKKVVGIMNGFLKRYQPVNLDKSPDNMFDLMIELDFGQADSSLTNAKQILNEIHKAYPILVPEIPKDDEIETAFRRSLDYKPTVRKIVGKGNNNQQKTPKLIKPTYISAKIENYDEIIELVKRCIASDAELTEKFKHLLASGKVQKELHITLGHVMSSREKEAKKLWKSYCNRYTDQITEYNNNRIENAQGSGNNQNTQVKTTDKLNFRLEKLCWDEKIIAIVVELSKDKDGCIIDENNEKIKGLCCQNKIPHITLCKLESGVKAVYSNVLCEKVESAEVDENIKVVKLDNSKEFVGSVYLNF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	YDGKRTVTQLVNELE CCCHHHHHHHHHHHH	18.64	28889911
20	Acetylation	QLVNELEKAEKLSGR HHHHHHHHHHHHCCC	74.58	24489116
86	Acetylation	IVARGYDKFFNVGEV EEEECCCCCCCCCCC	43.29	24489116
168	Phosphorylation	AAMNINRSDFARMLY HHCCCCHHHHHHHHH	32.37	29688323
284	Acetylation	TEKPFFFKYKFEEPY CCCCEEEEEEECCCC	42.23	24489116
286	Acetylation	KPFFFKYKFEEPYLM CCEEEEEEECCCCHH	47.06	24489116
309	Phosphorylation	KDYISNKSRVFKFRK HHHHHCCCCEEEECC	37.62	28889911
446	Acetylation	SLELLSKKEIKCVIV HHHHHHCCCCEEEEE	62.39	25381059
449	Acetylation	LLSKKEIKCVIVDRN HHHCCCCEEEEECCC	24.44	25381059

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRNL_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRNL_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRNL_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
YPT6_YEAST	YPT6	genetic	19061648
TRNL_SCHPO	trl1	genetic	20844078

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.