FLO5_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FLO5_YEAST
• UniProt AC: P38894
• Protein Name: Flocculation protein FLO5
• Gene Name: FLO5
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 1075
• Subcellular Localization: Secreted, cell wall . Membrane ; Lipid-anchor, GPI-anchor . Covalently-linked GPI-modified cell wall protein (GPI-CWP)..
• Protein Description: Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose..
• Protein Sequence: MTIAHHCIFLVILAFLALINVASGATEACLPAGQRKSGMNINFYQYSLKDSSTYSNAAYMAYGYASKTKLGSVGGQTDISIDYNIPCVSSSGTFPCPQEDSYGNWGCKGMGACSNSQGIAYWSTDLFGFYTTPTNVTLEMTGYFLPPQTGSYTFSFATVDDSAILSVGGSIAFECCAQEQPPITSTNFTINGIKPWDGSLPDNITGTVYMYAGYYYPLKVVYSNAVSWGTLPISVELPDGTTVSDNFEGYVYSFDDDLSQSNCTIPDPSIHTTSTITTTTEPWTGTFTSTSTEMTTITDTNGQLTDETVIVIRTPTTASTITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLISTTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTSEGLITTTTEPWTGTFTSTSTEMTTVTGTNGQPTDETVIVIRTPTSEGLITRTTEPWTGTFTSTSTEVTTITGTNGQPTDETVIVIRTPTTAISSSLSSSSGQITSSITSSRPIITPFYPSNGTSVISSSVISSSVTSSLVTSSSFISSSVISSSTTTSTSIFSESSTSSVIPTSSSTSGSSESKTSSASSSSSSSSISSESPKSPTNSSSSLPPVTSATTGQETASSLPPATTTKTSEQTTLVTVTSCESHVCTESISSAIVSTATVTVSGVTTEYTTWCPISTTETTKQTKGTTEQTKGTTEQTTETTKQTTVVTISSCESDICSKTASPAIVSTSTATINGVTTEYTTWCPISTTESKQQTTLVTVTSCESGVCSETTSPAIVSTATATVNDVVTVYPTWRPQTTNEQSVSSKMNSATSETTTNTGAAETKTAVTSSLSRFNHAETQTASATDVIGHSSSVVSVSETGNTMSLTSSGLSTMSQQPRSTPASSMVGSSTASLEISTYAGSANSLLAGSGLSVFIASLLLAII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	N-linked_Glycosylation	GFYTTPTNVTLEMTG EEEECCCCEEEEEEE	26.44	-
187	N-linked_Glycosylation	QPPITSTNFTINGIK CCCCCEECEEECCCC	31.65	-
203	N-linked_Glycosylation	WDGSLPDNITGTVYM CCCCCCCCCCEEEEE	31.61	-
262	N-linked_Glycosylation	DDDLSQSNCTIPDPS CCCCCCCCCCCCCCC	21.22	-
663	N-linked_Glycosylation	ITPFYPSNGTSVISS EECCCCCCCCEEEEH	53.94	-
733	Phosphorylation	KTSSASSSSSSSSIS CCCCCCCCCCCCCCC	31.57	29734811
734	Phosphorylation	TSSASSSSSSSSISS CCCCCCCCCCCCCCC	35.87	29734811
749	N-linked_Glycosylation	ESPKSPTNSSSSLPP CCCCCCCCCCCCCCC	43.19	-
1052	GPI-anchor	LEISTYAGSANSLLA EEEEECCCCHHHHHC	19.51	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FLO5_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FLO5_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FLO5_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SEC62_YEAST	SEC62	physical	18719252
YD476_YEAST	YDR476C	physical	18719252
GST1_YEAST	GTT1	physical	18719252
GAS1_YEAST	GAS1	genetic	23891562
CR3L1_HUMAN	CREB3L1	physical	27107014

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.