| UniProt ID | THI80_YEAST | |
|---|---|---|
| UniProt AC | P35202 | |
| Protein Name | Thiamine pyrophosphokinase | |
| Gene Name | THI80 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 319 | |
| Subcellular Localization | ||
| Protein Description | Essential protein, it is the only enzyme in yeast capable of synthesizing thiamine pyrophosphate (TPP).. | |
| Protein Sequence | MSEECIENPERIKIGTDLINIRNKMNLKELIHPNEDENSTLLILNQKIDIPRPLFYKIWKLHDLKVCADGAANRLYDYLDDDETLRIKYLPNYIIGDLDSLSEKVYKYYRKNKVTIIKQTTQYSTDFTKCVNLISLHFNSPEFRSLISNKDNLQSNHGIELEKGIHTLYNTMTESLVFSKVTPISLLALGGIGGRFDQTVHSITQLYTLSENASYFKLCYMTPTDLIFLIKKNGTLIEYDPQFRNTCIGNCGLLPIGEATLVKETRGLKWDVKNWPTSVVTGRVSSSNRFVGDNCCFIDTKDDIILNVEIFVDKLIDFL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEECIENP ------CCHHHHHCH | 41.94 | 22814378 | |
| 57 | Acetylation | IPRPLFYKIWKLHDL CCHHHHHHHHHHCCC | 34.45 | 24489116 | |
| 60 | Acetylation | PLFYKIWKLHDLKVC HHHHHHHHHCCCEEE | 39.14 | 24489116 | |
| 167 | Phosphorylation | ELEKGIHTLYNTMTE EECCHHHHHHHHCCH | 29.08 | 27017623 | |
| 169 | Phosphorylation | EKGIHTLYNTMTESL CCHHHHHHHHCCHHH | 15.11 | 29688323 | |
| 171 | Phosphorylation | GIHTLYNTMTESLVF HHHHHHHHCCHHHHH | 16.35 | 29688323 | |
| 173 | Phosphorylation | HTLYNTMTESLVFSK HHHHHHCCHHHHHCC | 22.00 | 29688323 | |
| 175 | Phosphorylation | LYNTMTESLVFSKVT HHHHCCHHHHHCCCC | 22.22 | 29688323 | |
| 179 | Phosphorylation | MTESLVFSKVTPISL CCHHHHHCCCCHHEE | 20.80 | 29688323 | |
| 278 | Phosphorylation | DVKNWPTSVVTGRVS CHHCCCCEEEECEEC | 15.54 | 27017623 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of THI80_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of THI80_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of THI80_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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